Results 51 to 60 of about 165,861 (406)

Beta-Lactam Probability of Target Attainment Success: Cefepime as a Case Study

Antibiotics, 2023
Introduction: Probability of target attainment (PTA) analysis using Monte Carlo simulations has become a mainstay of dose optimization. We highlight the technical and clinical factors that may affect PTA for beta-lactams.
Daniel J. Selig, Adrian T. Kress, Robert J. Nadeau, Jesse P. DeLuca   +3 more
doaj   +1 more source

Novel Cephalosporins Selectively Active on Nonreplicating Mycobacterium tuberculosis

Journal of Medicinal Chemistry, 2016
We report two series of novel cephalosporins that are bactericidal to Mycobacterium tuberculosis alone of the pathogens tested, which only kill M. tuberculosis when its replication is halted by conditions resembling those believed to pertain in the host,
B. Gold, Robert A. Smith, Q. Nguyen, Julia Roberts, Yan Ling, Landys Lopez Quezada, Selin Somersan, Thulasi Warrier, David Little, Maneesh R. Pingle, David Y. Zhang, E. Ballinger, M. Zimmerman, V. Dartois, P. Hanson, L. Mitscher, P. Porubsky, S. Rogers, F. Schoenen, C. Nathan, J. Aubé   +20 more
semanticscholar   +1 more source

Identification of New Drug Candidates Against \u3cem\u3eBorrelia burgdorferi\u3c/em\u3e Using High-Throughput Screening [PDF]

, 2016
Lyme disease is the most common zoonotic bacterial disease in North America. It is estimated that .300,000 cases per annum are reported in USA alone. A total of 10%–20% of patients who have been treated with antibiotic therapy report the recrudescence of
Babar, Mustafeez Mujtaba, Inayathullah, Mohammed, Kim, K. M., Parekh, Mansi B., Pothineni, Venkata Raveendra, Rajadas, Jayakumar, Samineni, A. V., Solow-Cordero, David, Tayebi, Lobat, Wagh, Dhananjay   +9 more
core   +3 more sources

Kinetics and Isotherm Study of Ceftriaxone Removal Using Functionalized Biochar Combined with Photocatalysis

Molecules
The increasing presence of antibiotics such as cephalosporins in wastewater represents a significant environmental risk. These compounds are excreted in large quantities, and conventional wastewater treatment plants are often ineffective at their removal.
Luísa Cruz-Lopes, Rodrigo Araújo, Ana Rita Lopes, Samuel Moles, Francisca Romero-Sarria, Bruno Esteves   +5 more
doaj   +1 more source

Molecular Epidemiology, Antimicrobial Surveillance, and PK/PD Analysis to Guide the Treatment of Neisseria gonorrhoeae Infections

Pharmaceutics, 2021
The aim of this study was to apply molecular epidemiology, antimicrobial surveillance, and PK/PD analysis to guide the antimicrobial treatment of gonococci infections in a region of the north of Spain.
Rodrigo Alonso, Ainara Rodríguez-Achaerandio, Amaia Aguirre-Quiñonero, Aitor Artetxe, Ilargi Martínez-Ballesteros, Alicia Rodríguez-Gascón, Javier Garaizar, Andrés Canut   +7 more
doaj   +1 more source

In vitro and in vivo evaluation of cephalosporins for the treatment of Lyme disease. [PDF]

, 2018
BackgroundLyme disease accounts for >90% of all vector-borne disease cases in the United States and affect ~300,000 persons annually in North America.
Ambati, Aditya, Babar, Mustafeez Mujtaba, Inayathullah, Mohammed, Kim, Kwang-Min, Maguire, Peter, Parekh, Mansi B, Pothineni, Venkata Raveendra, Potula, Hari-Hara Sk, Rajadas, Jayakumar, Tayebi, Lobat   +9 more
core  

Penicillin Use in Meningococcal Disease Management: Active Bacterial Core Surveillance Sites, 2009. [PDF]

, 2016
In 2009, in the Active Bacterial Core surveillance sites, penicillin was not commonly used to treat meningococcal disease. This is likely because of inconsistent availability of antimicrobial susceptibility testing and ease of use of third-generation ...
Anderson, Raydel, Blain, Amy, Clark, Thomas, Cohn, Amanda, Farley, Monica, Harcourt, Brian, Harrison, Lee, Lynfield, Ruth, MacNeil, Jessica, Mandal, Sema, Mayer, Leonard, Miller, Lisa, Nichols, Megin, Petit, Sue, REINGOLD, Arthur L., Schaffner, William, Thomas, Ann, Wu, Henry, Zansky, Shelley   +18 more
core   +2 more sources

De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning

Advanced Science, EarlyView.
Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li, Haifan Gong, Yue Wang, Yinuo Zhao, Lixiang Li, Peijing Bao, Qingzhou Kong, Jialu Fu, Boyao Wan, Yumeng Zhang, Jinghui Zhang, Jiekun Ni, Zhongxue Han, Xueping Nan, Kunping Ju, Longfei Sun, Yuerui Ma, Huijun Chang, Mengqi Zheng, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +23 more
wiley   +1 more source

High Prevalence of Multidrug-Resistant Nontyphoidal Salmonella Recovered from Broiler Chickens and Chicken Carcasses in Brazil

Brazilian Journal of Poultry Science
The extensive use of antimicrobial agents has contributed to the emergence of antimicrobial resistance and multidrug resistance (MDR) in Salmonella, an important zoonotic pathogen that causes outbreaks and sporadic cases of gastroenteritis in humans. The
IBBE Rodrigues, RL Silva, J Menezes, SCA Machado, DP Rodrigues, C Pomba, DLC Abreu, ER Nascimento, MHC Aquino, VLA Pereira   +9 more
doaj   +1 more source

In vitro Ceftaroline Activity against Major Bacterial Pathogens n Russia: Results of Multicenter Study [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2015
Background. Ceftaroline is a new broad-spectrum cephalosporin with in vitro activity against Gram-positive pathogens, including MRSA, and common Gram-negative pathogens.
Kozlov R.S., Sukhorukova M.V., Sidorenko S.V., Edelstein M.V., Skleenova E.Yu., Ivanchik N.V., Mikotina A.V., Gostev V.V., Lazareva I.V., Kalinogorskaya O.S., Volkova M.O., Dekhnich A.V.   +11 more
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