Results 31 to 40 of about 159,979 (309)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Novel Analytical Methods in Food Analysis
Foods, 2022 Food analysis is a discipline with a huge impact on both economical and medical aspects of modern societies, meaning that it is at the cornerstone between industrial, medical, and regulatory needs [...]
Philippe Delahaut, Riccardo Marega
doaj +1 more source
Medical Decision Making, 2009 Decisions imply choices between options, leading to a need for comparative information. Those decisions interesting enough to research tend not to be straightforward. This situation occurs frequently when the idiosyncrasies of the human body meet the creativity of medical science and the many new technologies developed annually.
openaire +2 more sources
Rolling over EUAs and CERs [PDF]
2012 9th International Conference on the European Energy Market, 2012 Whatever derivative contract has a finite life limited by their maturity. The construction of long series, however, is of interest for academic, hedging and investments purposes. In this study, we analyze the relevance of the choice of the rollover date on European Union Allowances (EUAs) and Certified Emissions Reduction (CERs) futures contracts.
Oscar Carchano +2 more
openaire +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Escenarios Económicos para Barrancabermeja al 2035: Aplicación del método Delphi
Panorama EconómicoObjetivos: El Distrito Especial de Barrancabermeja es conocido por su fuerte arraigo al sector de hidrocarburos, al albergar una de las refinerías más grandes de Colombia, lo que lo convierte en el municipio más importante de Santander desde la ...
Silvia Natalia Cuéllar Campos +2 more
doaj +1 more source
Plasma ceramides containing saturated fatty acids are associated with risk of type 2 diabetes
Journal of Lipid Research, 2021 Recent studies suggest that the type of saturated fatty acid bound to sphingolipids influences the biological activity of those sphingolipids. However, it is unknown whether associations of sphingolipids with diabetes may differ by the identity of bound ...
Amanda M. Fretts +11 more
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Kavram Dağarcığının Geliştirilmesinde Düzeye Uygun Bir Çocuk Kitabının Etkisi: Bir Uygulama Örneği
Ana Dili Eğitimi Dergisi, 2020 Bu araştırmanın amacı, kavram dağarcığının geliştirilmesinde düzeye uygun bir çocuk kitabının etkisini incelemektir. Bu durum, düzeye uygun çocuk edebiyatı yapıtlarının kavram dağarcığı üzerindeki etkilerini ortaya çıkartabilir.
Erkan ÇER
doaj +1 more source