Results 51 to 60 of about 1,220,271 (288)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Chile Fiscal Policy Management [PDF]

open access: yes, 2013
A budget surplus arises in a country when the total revenue earnings surpass expenditures in a particular financial year. Having a budget surplus is very important in the sense that it brings about a decrease in the net public debt, while the public debt
Betancourt, Erico Wulf   +1 more
core   +2 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

open access: yesFEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

PHARMACOECONOMIC STUDY OF OLMESARTAN/LERCANIDIPINE AND OFENOPRIL/LERCANIDIPINE COMBINATIONS IN THE TREATMENT OF PATIENTS WITH ESSENTIAL HYPERTENSION

open access: yesФармакоэкономика, 2017
Objective. Pharmacoeconomic analysis of the use of combinations of antihypertensive drugs were olmesartan/lercanidipine and zofenopril/lercanidipine in patients with essential hypertension II-III stage.Materials and methods.
D. S. Kaskaeva   +2 more
doaj   +1 more source

Does Community and Environmental Responsibility Affect Firm Risk? Evidence from UK Panel Data 1994-2006 [PDF]

open access: yes, 2009
The question of how an individual firm’s environmental performance impacts its firm risk has not been examined in any empirical UK research. Does a company that strives to attain good environmental performance decreases its market risk or is ...
Anderson, K., Salama, A., Toms, S.
core  

Spoken Language Intent Detection using Confusion2Vec

open access: yes, 2019
Decoding speaker's intent is a crucial part of spoken language understanding (SLU). The presence of noise or errors in the text transcriptions, in real life scenarios make the task more challenging.
Georgiou, Panayiotis   +2 more
core   +1 more source

Sphingolipids as emerging mediators in retina degeneration [PDF]

open access: yes, 2019
The sphingolipids ceramide (Cer), sphingosine-1-phosphate (S1P), sphingosine (Sph), and ceramide-1-phosphate (C1P) are key signaling molecules that regulate major cellular functions.
Prado Spalm, Facundo Heber   +3 more
core   +1 more source

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang   +10 more
wiley   +1 more source

Application of the WRF Model for Operational Wind Power Forecasting in Northeast Brazil

open access: yesEnergies
Northeastern Brazil (NEB) has a high potential for wind energy generation, making it a strategic area for the development of this renewable source. However, the region’s complex wind regime, driven by interactions between large-scale atmospheric systems,
Thiago Silva   +9 more
doaj   +1 more source

Comparative Analysis Of The Utilisation Of Electronic Commerce And Business In Polish E-shops In The Years 2009-2011 [PDF]

open access: yes, 2013
The aim of the article is to present the results of research concerning the utilisation of different aspects of electronic commerce and business in Polish e-shops, based on a number of comparative analyses performed for the years 2009-2011.
Czajkowski, Tomasz, Szymański, Grzegorz
core   +2 more sources

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