Translation of Ceragenin Affinity for Bacteria to an Imaging Reagent for Infection [PDF]
RSC Advances, 2019 Infection imaged via autoradiography with ceragenin conjugated to a copper radiolabel.
Xiaobo Gu +2 more
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Biological Properties of Ceragenin-Coated Metal Nanoparticles – Future Challenges and Perspectives in Clinical Practice [PDF]
NanomedicineRobert Bucki +2 more
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The application of ceragenins to orthopedic surgery and medicine
Journal of Orthopaedic Research, 2020AbstractOsteomyelitis and infections associated with orthopedic implants represent a significant burden of disease worldwide. Ceragenins (CSAs) are a relatively new class of small‐molecule antimicrobials that target a broad range of Gram‐positive and Gram‐negative bacteria as well as fungi, viruses, and parasites.
Aiken Dao +5 more
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In vitro activity of ceragenins against Burkholderia cepacia complex
The Journal of Antibiotics, 2022Burkholderia cepacia complex (Bcc) species are aerobic, Gram-negative and non-fermantative bacilli. Bcc can cause clinical symptoms in patients with cystic fibrosis, ranging from asymptomatic carriage to fatal pneumonia. A pressing need exists for new antimicrobial agents that target Bcc.
Oyardi, Özlem +4 more
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In Vitro Evaluation of the Potential for Resistance Development to Ceragenin CSA-13. [PDF]
Journal of Antimicrobial Chemotherapy, 2012 Though most bacteria remain susceptible to endogenous antimicrobial peptides, specific resistance mechanisms are known. As mimics of antimicrobial peptides, ceragenins were expected to retain antibacterial activity against Gram-positive and -negative bacteria, even after prolonged exposure.
Jon O Wright +2 more
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Ceragenins: Cholic Acid-Based Mimics of Antimicrobial Peptides
Accounts of Chemical Research, 2008The prevalence of drug-resistant bacteria drives the quest for new antimicrobials, including those that are not expected to readily engender resistance. One option is to mimic Nature's most ubiquitous means of controlling bacterial growth, antimicrobial peptides, which have evolved over eons.
Lai, Xin-Zhong +8 more
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Ceragenin CSA-13 Exhibits Antimicrobial Activity Against Cariogenic and Periodontopathic Bacteria
Oral Microbiology and Immunology, 2009Introduction: Ceragenin CSA‐13 is a bile‐acid‐based mimic of endogenous antimicrobial peptides and shares a mechanism of action with many of these antimicrobial agents. Because CSA‐13 is not peptide based, it is not a substrate for the proteases that are found in the oral cavity, which are capable of degrading antimicrobial peptides.
Paul B Savage, E Isogai
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Ceragenins (Cationic Steroid Compounds), a Novel Class of Antimicrobial Agents
Drug News & Perspectives, 2008Ceragenins are a group of cholic acid derivatives that have been chemically modified to make them cationic amphiphiles. Several of these derivatives exhibit antimicrobial activity against a broad range of bacteria. These compounds have advantages over cationic amphipathic peptides in that they are resistant to proteolysis and they incorporate stably ...
Richard M, Epand +2 more
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Antibiofilm Potential of Ceragenins Against Vancomycin-Resistant Enterococcus spp.
Fabad Journal of Pharmaceutical SciencesEnterococcus spp., especially vancomycin-resistant enterococci (VRE), are listed by the World Health Organization as priority pathogens requiring new antimicrobial treatments.Ceragenins (CSAs) are a novel class of broad-spectrum antimicrobials that are relatively easy and cost-effective to produce. This study evaluated the antibacterial and antibiofilm
Müzeyyen Aydın +5 more
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