Results 1 to 10 of about 418 (139)

Ceragenins and Ceragenin-Based Core-Shell Nanosystems as New Antibacterial Agents Against Gram-Negative Rods Causing Nosocomial Infections [PDF]

Pathogens, 2023
The growing number of infections caused by multidrug-resistant bacterial strains, limited treatment options, multi-species infections, high toxicity of the antibiotics used, and an increase in treatment costs are major challenges for modern medicine.
Robert Bucki, Urszula Wnorowska, Tamara Daniluk   +2 more
exaly   +7 more sources

Ceragenins in Combination With Ivacaftor Prevent the Formation of Biofilm by Bacteria That Cause Rhinosinusitis [PDF]

Pharmaceutics
Background/Objectives: Ceragenins (CSAs) maintain strong antibacterial activity even in cystic fibrosis (CF) sputum. Ivacaftor (IVA), a CF transmembrane regulator modulator, provides significant clinical benefits in CF therapy. Based on these properties,
Robert Bucki, Paul B Savage, Jakub Spałek   +2 more
exaly   +7 more sources

Efficacy of Ceragenins in Controlling the Growth of Oral Microorganisms: Implications for Oral Hygiene Management [PDF]

Pharmaceuticals
Ensuring proper dental hygiene is of paramount importance for individuals’ general well-being, particularly for patients receiving medical care. There is a prevailing utilization of conventional oral hygiene items, including toothbrushes and mouthwashes,
Robert Bucki, Paul B Savage, Maciej Karasiński   +2 more
exaly   +7 more sources

Ceragenins and Antimicrobial Peptides Kill Bacteria through Distinct Mechanisms [PDF]

mBio, 2022
Ceragenins are a family of synthetic amphipathic molecules designed to mimic the properties of naturally occurring cationic antimicrobial peptides (CAMPs). Although ceragenins have potent antimicrobial activity, whether their mode of action is similar to
Gabriel Mitchell, Melanie R. Silvis, Kelsey C. Talkington, Jonathan M. Budzik, Claire E. Dodd, Justin M. Paluba, Erika A. Oki, Kristine L. Trotta, Daniel J. Licht, David Jimenez-Morales, Seemay Chou, Paul B. Savage, Carol A. Gross, Michael A. Marletta, Jeffery S. Cox   +14 more
doaj   +10 more sources

Natural Antimicrobial Peptides and Their Synthetic Analogues for Effective Oral Microflora Control and Oral Infection Treatment—The Role of Ceragenins in the Development of New Therapeutic Methods [PDF]

Pharmaceuticals
Oral diseases, both acute and chronic, of infectious or non-infectious etiology, represent some of the most serious medical problems in dentistry. Data from the literature increasingly indicate that changes in the oral microbiome, and therefore, the ...
Ewelina Dargiewicz, Robert Bucki, Urszula Wnorowska   +2 more
exaly   +5 more sources

Incorporation of Ceragenins Into Medical Adhesives and Adhesive Scar Tape to Prevent Microbial Colonization Common in Healthcare-Associated Infections [PDF]

Antibiotics
Background/Objectives: Healthcare-associated infections involving surgical sites, skin trauma, and devices penetrating the skin are a frequent source of increased expense, hospitalization periods, and adverse outcomes.
Paul B Savage, James E Patterson, Boston Boyack   +2 more
exaly   +5 more sources

Antimicrobial Activity of Ceragenins against Vancomycin-Susceptible and -Resistant Enterococcus spp. [PDF]

Pharmaceuticals, 2023
Ceragenins (CSAs) are a new class of antimicrobial agents designed to mimic the activities of endogenous antimicrobial peptides. In this study, the antibacterial activities of various ceragenins (CSA-13, CSA-44, CSA-90, CSA-131, CSA-138, CSA-142, and CSA-
Mayram Hacioglu, Fatima Nur Yilmaz, Ozlem Oyardi, Cagla Bozkurt Guzel, Nese Inan, Paul B. Savage, Sibel Dosler   +6 more
doaj   +3 more sources

Ceragenins Exhibit Bactericidal Properties That Are Independent of the Ionic Strength in the Environment Mimicking Cystic Fibrosis Sputum [PDF]

Frontiers in Microbiology, 2023
The purpose of the work was to investigate the impact of sodium chloride (NaCl) on the antimicrobial efficacy of ceragenins (CSAs) and antimicrobial peptides (AMPs) against bacterial and fungal pathogens associated with cystic fibrosis (CF) lung ...
Robert Bucki, Paul B Savage, Szczepan Kaliniak   +2 more
exaly   +4 more sources

Phenotypic Investigation of Virulence Factors, Susceptibility to Ceragenins, and the Impact of Biofilm Formation on Drug Efficacy in Candida auris Isolates from Türkiye [PDF]

Journal of Fungi, 2023
Candida auris has emerged as a significant fungal threat due to its rapid worldwide spread since its first appearance, along with its potential for antimicrobial resistance and virulence properties.
Ozlem Oyardi, Elif Sena Demir, Busra Alkan, Selda Komec, Gonca Erkose Genc, Gokhan Aygun, Leyla Teke, Deniz Turan, Zayre Erturan, Paul B. Savage, Cagla Bozkurt Guzel   +10 more
doaj   +3 more sources

NDM-1 Carbapenemase-Producing Enterobacteriaceae Are Highly Susceptible to Ceragenins CSA-13, CSA-44, and CSA-131 [PDF]

Infection and Drug Resistance, 2020
Sylwia Joanna Chmielewska,1 Karol Skłodowski,1 Ewelina Piktel,1 Łukasz Suprewicz,1 Krzysztof Fiedoruk,1 Tamara Daniluk,1 Przemysław Wolak,2 Paul B Savage,3 Robert Bucki1 1Department of Medical Microbiology and Nanobiomedical Engineering, Medical ...
Łukasz Suprewicz, Krzysztof Fiedoruk, Robert Bucki   +2 more
exaly   +4 more sources