Results 21 to 30 of about 418 (139)

Glyoxylate Shunt and Pyruvate-to-Acetoin Shift Are Specific Stress Responses Induced by Colistin and Ceragenin CSA-13 in Enterobacter hormaechei ST89 [PDF]

Microbiology Spectrum, 2023
Ceragenins, including CSA-13, are cationic antimicrobials that target the bacterial cell envelope differently than colistin. However, the molecular basis of their action is not fully understood.
Suhanya V. Prasad, Krzysztof Fiedoruk, Magdalena Zakrzewska, Paul B. Savage, Robert Bucki   +4 more
doaj   +2 more sources

Candidacidal Activity of Selected Ceragenins and Human Cathelicidin LL-37 in Experimental Settings Mimicking Infection Sites. [PDF]

PLoS ONE, 2016
Fungal infections, especially those caused by antibiotic resistant pathogens, have become a serious public health problem due to the growing number of immunocompromised patients, including those subjected to anticancer treatment or suffering from HIV ...
Bonita Durnaś, Urszula Wnorowska, Katarzyna Pogoda, Piotr Deptuła, Marzena Wątek, Ewelina Piktel, Stanisław Głuszek, Xiaobo Gu, Paul B Savage, Katarzyna Niemirowicz, Robert Bucki   +10 more
doaj   +2 more sources

Bactericidal activity of ceragenin CSA-13, CSA-44 and CSA-131 against bacteria causing bloodstream infections [PDF]

Frontiers in Microbiology
IntroductionThe constantly growing resistance of bacteria causing bloodstream infections and the lack of alternative antibiotics generate the need to develop new therapeutic strategies. In this study, the antibacterial properties of synthetic cholic acid
Angelika Mańkowska, Paulina Paprocka, Łukasz Suprewicz, Agata Lesiak, Kamila Fortunka, Grzegorz Król, Jakub Spałek, Jakub Spałek, Sławomir Okła, Sławomir Okła, Bonita Durnaś, Tamara Daniluk, Ewelina Piktel, Paul B. Savage, Robert Bucki, Robert Bucki   +15 more
doaj   +2 more sources

Ceragenins – a new weapon to fight multidrug resistant bacterial infections [PDF]

Studia Medyczne, 2014
Growing antibiotic resistance among pathogenic microorganisms is one of the most challenging problems. Often, a single mutation in a bacterial cell leads to the formation of a new drug resistance mechanism. The ceragenins are a novel class of antibiotic,
Urszula Surel, Katarzyna Niemirowicz, Michal Marzec, Paul B. Savage, Robert Bucki   +4 more
doaj   +2 more sources

Anaerobic bacteria growth in the presence of cathelicidin LL-37 and selected ceragenins delivered as magnetic nanoparticles cargo

BMC Microbiology, 2017
Background Cationic antibacterial peptides (CAPs) and synthetic molecules mimicking the amphiphilic structure of CAPs, such as ceragenins, are promising compounds for the development of new antimicrobials.
Bonita Durnaś, Ewelina Piktel, Marzena Wątek, Tomasz Wollny, Stanisław Góźdź, Jolanta Smok-Kalwat, Katarzyna Niemirowicz, Paul B. Savage, Robert Bucki   +8 more
doaj   +2 more sources

Ceragenin CSA-13 displays high antibacterial efficiency in a mouse model of urinary tract infection [PDF]

Scientific Reports, 2022
Ceragenins (CSAs) are synthetic, lipid-based molecules that display activities of natural antimicrobial peptides. Previous studies demonstrated their high in vitro activity against pathogens causing urinary tract infections (UTIs), but their efficiency ...
Urszula Wnorowska, Ewelina Piktel, Piotr Deptuła, Tomasz Wollny, Grzegorz Król, Katarzyna Głuszek, Bonita Durnaś, Katarzyna Pogoda, Paul B. Savage, Robert Bucki   +9 more
doaj   +2 more sources

In vitro activity of ceragenins against Burkholderia cepacia complex

The Journal of Antibiotics, 2022
Burkholderia cepacia complex (Bcc) species are aerobic, Gram-negative and non-fermantative bacilli. Bcc can cause clinical symptoms in patients with cystic fibrosis, ranging from asymptomatic carriage to fatal pneumonia.
Bozkurt-Guzel, Cagla, Savage, P. B., Demir, Elif Sena, Altay, Özlem,, Savage, Paul B, Oyardi, O., Savage, Paul B., Bozkurt-Guzel, C., Oyardi, Ozlem, Altay, Havva Ozlem, Demir, E. S., Havva Ozlem Altay, Ozlem Oyardi, Elif Sena Demir, Paul B. Savage, Cagla Bozkurt-Guzel   +15 more
core   +4 more sources

Proteomic Analysis of Resistance of Gram-Negative Bacteria to Chlorhexidine and Impacts on Susceptibility to Colistin, Antimicrobial Peptides, and Ceragenins [PDF]

Frontiers in Microbiology, 2019
Use of chlorhexidine in clinical settings has led to concerns that repeated exposure of bacteria to sub-lethal doses of chlorhexidine might result in chlorhexidine resistance and cross resistance with other cationic antimicrobials including colistin ...
Marjan M. Hashemi, Brett S. Holden, Jordan Coburn, Maddison F. Taylor, Scott Weber, Brian Hilton, Aaron L. Zaugg, Colten McEwan, Richard Carson, Joshua L. Andersen, John C. Price, Shenglou Deng, Paul B. Savage   +12 more
doaj   +2 more sources

Linking ceragenins to water-treatment membranes to minimize biofouling. [PDF]

, 2012
Ceragenins were used to create biofouling resistant water-treatment membranes. Ceragenins are synthetically produced antimicrobial peptide mimics that display broad-spectrum bactericidal activity.
Pollard, Jacob (Brigham Young University, Provo, Utah), Branda, Steven S., Jones, Howland D. T., Feng, Yanshu (Brigham Young University, Provo, Utah), Altman, Susan Jeanne, Goeres, Darla (Montana State University, Bozeman, MT), Buckingham-Meyer, Kelli (Montana State University, Bozeman, MT), McGrath, Lucas K. (LMATA, Albuquerque, NM), Stafslien, Shane (North Dakota State University, Fargo, ND), Kirk, Matthew F., Savage, Paul B. (Brigham Young University, Provo, Utah), Marry, Christopher, Hibbs, Michael R., Lichtenberger, Alyssa   +13 more
core   +4 more sources

Evaluation of the in vitro activity of ceragenins against Trichomonas vaginalis

Acta Parasitologica, 2016
Trichomonosis, caused by the protozoan parasite Trichomonas vaginalis, is a curable sexually transmitted disease that is most commonly encountered worldwide. Increasing importance of trichomoniasis and emerging of resistance against metronidazole lead to
Savage, Paul B., Cetin, Ali, Polat, Zubeyde Akin, Polat, Zübeyda   +3 more
core   +4 more sources