Results 1 to 10 of about 74,543,549 (272)

NDM-1 Carbapenemase-Producing Enterobacteriaceae Are Highly Susceptible to Ceragenins CSA-13, CSA-44, and CSA-131 [PDF]

Infection and Drug Resistance, 2020
Sylwia Joanna Chmielewska,1 Karol Skłodowski,1 Ewelina Piktel,1 Łukasz Suprewicz,1 Krzysztof Fiedoruk,1 Tamara Daniluk,1 Przemysław Wolak,2 Paul B Savage,3 Robert Bucki1 1Department of Medical Microbiology and Nanobiomedical Engineering, Medical ...
Łukasz Suprewicz, Krzysztof Fiedoruk, Robert Bucki   +2 more
exaly   +9 more sources

Ceragenin CSA-13 displays high antibacterial efficiency in a mouse model of urinary tract infection [PDF]

Scientific Reports, 2022
Ceragenins (CSAs) are synthetic, lipid-based molecules that display activities of natural antimicrobial peptides. Previous studies demonstrated their high in vitro activity against pathogens causing urinary tract infections (UTIs), but their efficiency ...
Urszula Wnorowska, Ewelina Piktel, Piotr Deptuła, Tomasz Wollny, Grzegorz Król, Katarzyna Głuszek, Bonita Durnaś, Katarzyna Pogoda, Paul B. Savage, Robert Bucki   +9 more
doaj   +5 more sources

Glyoxylate Shunt and Pyruvate-to-Acetoin Shift Are Specific Stress Responses Induced by Colistin and Ceragenin CSA-13 in Enterobacter hormaechei ST89 [PDF]

Microbiology Spectrum, 2023
Ceragenins, including CSA-13, are cationic antimicrobials that target the bacterial cell envelope differently than colistin. However, the molecular basis of their action is not fully understood.
Suhanya V. Prasad, Krzysztof Fiedoruk, Magdalena Zakrzewska, Paul B. Savage, Robert Bucki   +4 more
doaj   +4 more sources

Formulation and candidacidal activity of magnetic nanoparticles coated with cathelicidin LL-37 and ceragenin CSA-13 [PDF]

Scientific Reports, 2017
Fungal infections caused by Candida spp. represent an emerging problem during treatment of immunocompromised patients and those hospitalized with serious principal diseases.
Katarzyna Niemirowicz, Bonita Durnaś, Grażyna Tokajuk, Ewelina Piktel, Grzegorz Michalak, Xiaobo Gu, Alina Kułakowska, Paul B. Savage, Robert Bucki   +8 more
doaj   +6 more sources

Bactericidal activity of ceragenin CSA-13, CSA-44 and CSA-131 against bacteria causing bloodstream infections [PDF]

Frontiers in Microbiology
IntroductionThe constantly growing resistance of bacteria causing bloodstream infections and the lack of alternative antibiotics generate the need to develop new therapeutic strategies. In this study, the antibacterial properties of synthetic cholic acid
Angelika Mańkowska, Paulina Paprocka, Łukasz Suprewicz, Agata Lesiak, Kamila Fortunka, Grzegorz Król, Jakub Spałek, Jakub Spałek, Sławomir Okła, Sławomir Okła, Bonita Durnaś, Tamara Daniluk, Ewelina Piktel, Paul B. Savage, Robert Bucki, Robert Bucki   +15 more
doaj   +5 more sources

In vitro bactericidal and bacteriolytic activity of ceragenin CSA-13 against planktonic cultures and biofilms of Streptococcus pneumoniae and other pathogenic streptococci. [PDF]

PLoS ONE, 2014
Ceragenin CSA-13, a cationic steroid, is here reported to show a concentration-dependent bactericidal/bacteriolytic activity against pathogenic streptococci, including multidrug-resistant Streptococcus pneumoniae.
Miriam Moscoso, María Esteban-Torres, Margarita Menéndez, Ernesto García   +3 more
doaj   +7 more sources

Ceragenin-Coated Non-Spherical Gold Nanoparticles as Novel Candidacidal Agents

Pharmaceutics, 2021
Background: Infections caused by Candida spp. have become one of the major causes of morbidity and mortality in immunocompromised patients. Therefore, new effective fungicides are urgently needed, especially due to an escalating resistance crisis ...
Karol Skłodowski, Sylwia Joanna Chmielewska, Joanna Depciuch, Piotr Deptuła, Ewelina Piktel, Tamara Daniluk, Magdalena Zakrzewska, Michał Czarnowski, Mateusz Cieśluk, Bonita Durnaś, Magdalena Parlińska-Wojtan, Paul B. Savage, Robert Bucki   +12 more
doaj   +1 more source

Candidacidal Activity of Selected Ceragenins and Human Cathelicidin LL-37 in Experimental Settings Mimicking Infection Sites. [PDF]

PLoS ONE, 2016
Fungal infections, especially those caused by antibiotic resistant pathogens, have become a serious public health problem due to the growing number of immunocompromised patients, including those subjected to anticancer treatment or suffering from HIV ...
Bonita Durnaś, Urszula Wnorowska, Katarzyna Pogoda, Piotr Deptuła, Marzena Wątek, Ewelina Piktel, Stanisław Głuszek, Xiaobo Gu, Paul B Savage, Katarzyna Niemirowicz, Robert Bucki   +10 more
doaj   +1 more source

Antimicrobial Activity of Ceragenins against Vancomycin-Susceptible and -Resistant Enterococcus spp.

Pharmaceuticals, 2023
Ceragenins (CSAs) are a new class of antimicrobial agents designed to mimic the activities of endogenous antimicrobial peptides. In this study, the antibacterial activities of various ceragenins (CSA-13, CSA-44, CSA-90, CSA-131, CSA-138, CSA-142, and CSA-
Mayram Hacioglu, Fatima Nur Yilmaz, Ozlem Oyardi, Cagla Bozkurt Guzel, Nese Inan, Paul B. Savage, Sibel Dosler   +6 more
doaj   +1 more source

Low cyclosporine concentrations in children and time to acute graft versus host disease

BMC Pediatrics, 2020
Background Achievement of target blood concentrations of cyclosporine (CsA) early after transplantation is known to be highly effective for reducing the incidence of acute graft versus host disease (aGVHD).
Eun Kyung Chung, Jeong Yee, Jae Youn Kim, Hye Sun Gwak   +3 more
doaj   +1 more source