Results 21 to 30 of about 74,543,549 (272)

In vitro evaluation of the potential for resistance development to ceragenin CSA-13 [PDF]

Journal of Antimicrobial Chemotherapy, 2012
Though most bacteria remain susceptible to endogenous antimicrobial peptides, specific resistance mechanisms are known. As mimics of antimicrobial peptides, ceragenins were expected to retain antibacterial activity against Gram-positive and -negative bacteria, even after prolonged exposure.
Jake E, Pollard, Jason, Snarr, Vinod, Chaudhary, Jacob D, Jennings, Hannah, Shaw, Bobbie, Christiansen, Jonathan, Wright, Wenyi, Jia, Russell E, Bishop, Paul B, Savage   +9 more
openaire   +2 more sources

Potential of ceragenin CSA-13 and its mixture with pluronic F-127 as treatment of topical bacterial infections [PDF]

Journal of Applied Microbiology, 2010
Ceragenin CSA-13 is a synthetic mimic of cationic antibacterial peptides, with facial amphiphilic morphology reproduced using a cholic acid scaffold. Previous data have shown that this molecule displays broad-spectrum antibacterial activity, which decreases in the presence of blood plasma.
Katarzyna Leszczyńska, Andrzej Namiot, Cruz, Katrina, Byfield, Fitzroy, Won, Esther, Mendez, G., Sokołowski, Wojciech, Savage, Paul, Robert Bucki, Janmey, Paul   +9 more
openaire   +4 more sources

Effect of a low concentration of a cationic steroid antibiotic (CSA-13) on the formation of a biofilm by Pseudomonas aeruginosa [PDF]

Journal of Applied Microbiology, 2011
Cationic steroids like CSA-13 have been designed by analogy with antimicrobial cationic peptides and have bactericidal properties. The purpose of this work was to evaluate the effect of a low concentration (1 mg l(-1)) of CSA-13 on the formation of a biofilm by eight strains of Pseudomonas aeruginosa (four mucoid and four nonmucoid strains) on an inert
C. Nagant, Y. Feng, B. Lucas, K. Braeckmans, P. Savage, J.P. Dehaye   +5 more
openaire   +4 more sources

Ceragenin CSA-13 as free molecules and attached to magnetic nanoparticle surfaces induce caspase-dependent apoptosis in human breast cancer cells via disruption of cell oxidative balance. [PDF]

Oncotarget, 2018
Natural antimicrobial peptides and ceragenins, as non-peptide amphipathic mimics, have been proposed as anti-cancer agents. To date, it has been confirmed that cathelicidin LL-37 and ceragenin CSA-13, both in free form and immobilized on the surface of magnetic nanoparticles (MNP@LL-37, MNP@CSA-13) induce apoptosis in colon cancer cells.
Piktel E, Prokop I, Wnorowska U, Król G, Cieśluk M, Niemirowicz K, Savage PB, Bucki R.   +7 more
europepmc   +5 more sources

Salivary mucins inhibit antibacterial activity of the cathelicidin-derived LL-37 peptide but not the cationic steroid CSA-13 [PDF]

Journal of Antimicrobial Chemotherapy, 2008
Cationic antimicrobial peptides (CAPs) are the effector molecules of innate immunity, similar in potency to classic antibiotics that function in the first-line of defence against infectious agents. The purpose of this study was to investigate the effects of negatively charged mucins on the antibacterial activity of the positively charged cathelicidin ...
Robert Bucki, Dorota Namiot, Zbigniew Namiot, Savage, Paul, Janmey, Paul   +4 more
openaire   +2 more sources

Relation of Non-Suicidal Self-Harm to Emotion Regulation and Alexithymia in Sexually Abused Children and Adolescents

European Psychiatry, 2023
Introduction Globally, children are abused sexually. It physically and mentally strains society. Abusers can develop eating problems and non-suicidal self-harm. Emotion regulation links purging, NSSI, and abusive situations.
M. M. Mohamed
doaj   +1 more source

Offsetting the cost of Community Support Agriculture (CSA) for low-income families: Perceptions and experiences of CSA farmers and members

, 2021
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is ...
Jilcott Pitts, Stephanie B., Alice S. Ammerman, Jane Kolodinsky, Karla L. Hanson, Amari Sealey, Jared T. McGuirt, Rebecca Seguin-Fowler, Marilyn Sitaker, Emily H. Belarmino, Florence Becot, Stephanie B. Jilcott Pitts, Leah Connor Volpe, Weiwei Wang   +12 more
core   +1 more source

Inhibition of Pterygium Fibroblast Migration and Outgrowth by Bevacizumab and Cyclosporine A Involves Down-Regulation of Matrix Metalloproteinases-3 and -13. [PDF]

PLoS ONE, 2017
We examined the connection between matrix metalloproteinase (MMP) expression/activity and pterygium fibroblast migration, and how these were affected by bevacizumab and/or cyclosporine A (CsA).
Yeoun-Hee Kim, Jae-Chang Jung, Sang Il Gum, Su-Bin Park, Jin Yeul Ma, Yong Il Kim, Kyoo Won Lee, Young Jeung Park   +7 more
doaj   +1 more source

Anaerobic bacteria growth in the presence of cathelicidin LL-37 and selected ceragenins delivered as magnetic nanoparticles cargo

BMC Microbiology, 2017
Background Cationic antibacterial peptides (CAPs) and synthetic molecules mimicking the amphiphilic structure of CAPs, such as ceragenins, are promising compounds for the development of new antimicrobials.
Bonita Durnaś, Ewelina Piktel, Marzena Wątek, Tomasz Wollny, Stanisław Góźdź, Jolanta Smok-Kalwat, Katarzyna Niemirowicz, Paul B. Savage, Robert Bucki   +8 more
doaj   +1 more source

The Role of Technology in the Perpetration of Childhood Sexual Abuse: The Importance of Considering Both In-Person and Online Interactions

Children, 2023
Child sexual abuse (CSA) is a pervasive global problem. To date, prevention efforts have largely focused on legislative efforts, parent and child education, and environmental protections. Due to the proliferation of the Internet, and especially since the
Elizabeth L. Jeglic, Georgia M. Winters
doaj   +1 more source