Results 11 to 20 of about 74,543,549 (272)

In Vitro Activities of the Cationic Steroid Antibiotics CSA-13, CSA-131, CSA-138, CSA-142, and CSA-192 Against Carbapenem-resistant Pseudomonas aeruginosa. [PDF]

Turk J Pharm Sci, 2020
Objectives: Pseudomonas aeruginosa is an important opportunistic pathogen that is difficult to treat because of the antibiotic resistance that has developed in recent years. Increasing carbapenem resistance has led to a rise in hospital infections caused
Bozkurt Güzel Ç, Avci NM, Savage P.
europepmc   +4 more sources

Investigation of the Antifungal Activities of the Cationic Steroid Antibiotic CSA-8, CSA-13, CSA-44, CSA-131 and CSA-138 Against Candida albicans Isolated from Blood Cultures [PDF]

ANKEM Dergisi, 2014
Cerageninler, antimikrobiyal peptitlere benzer aktivite gösteren, yeni bir grup katyonik steroid antimikrobiyal molekül- lerdir. Bu çalışmada kan kültürlerinden izole edilmiş Candida albicans suşlarına karşı katyonik steroid antibiyotiklerden olan CSA-8,
Çağla Güzel Bozkurt, Maryam Tüysüz, Paul B. Savage, Neşe İnan   +3 more
core   +3 more sources

Potential Synergy Activity of the Novel Ceragenin, CSA-13, against Carbapenem-Resistant Acinetobacter baumannii Strains Isolated from Bacteremia Patients [PDF]

BioMed Research International, 2014
Carbapenem-resistant Acinetobacter baumannii is an important cause of nosocomial infections, particularly in patients in the intensive care units. As chronic infections are difficult to treat, attempts have been made to discover new antimicrobials ...
Ozbek-Celik, Berna, AKÇALI, ALPER, SAVAGE, Paul B., Bozkurt-Guzel, Çağla, Alper Akçalı   +4 more
core   +6 more sources

Comparative in vitro antimicrobial activities of CSA-142 and CSA-192, second-generation ceragenins, with CSA-13 against various microorganisms

Journal of Chemotherapy, 2018
Ceragenins, a novel family of antibiotics, are cationic derivatives of cholic acid and display broad-spectrum antimicrobial activities. Multiple ceragenins have been synthesized and studied, and most published data are with ceragenin CSA-13.
Bozkurt Güzel, Çağla, Oyardı, Özlem, Savage, Paul B.   +2 more
core   +5 more sources

Bactericidal activities of the cationic steroid CSA-13 and the cathelicidin peptide LL-37 against Helicobacter pylori in simulated gastric juice [PDF]

BMC Microbiology, 2009
Background The worldwide appearance of drug-resistant strains of H. pylori motivates a search for new agents with therapeutic potential against this family of bacteria that colonizes the stomach, and is associated with adenocarcinoma development.
Janmey Paul A, Diamond Scott, Savage Paul B, Namiot Zbigniew, Wen Qi, Fein David E, Namiot Andrzej, Leszczyńska Katarzyna, Bucki Robert   +8 more
doaj   +3 more sources

Interaction between tobramycin and CSA-13 on clinical isolates of Pseudomonas aeruginosa in a model of young and mature biofilms.

Applied Microbiology and Biotechnology, 2010
The bactericidal activity of a cholic acid antimicrobial derivative, CSA-13, was tested against eight strains of Pseudomonas aeruginosa (both reference and clinical strains) and compared with the response to tobramycin.
El Ouaaliti, Malika, Malika El-Ouaaliti, Paul Savage, Michel Devleeschouwer, Savage, Paul, Devleeschouwer, Michel, Savage, P B, Tré-Hardy, Marie, Jean-Paul Dehaye, El-Ouaaliti, Malika, Carole Nagant, Dehaye, Jean-Paul, Nagant, Carole, Marie Tré-Hardy   +13 more
core   +4 more sources

Sporicidal activity of ceragenin CSA-13 against Bacillus subtilis. [PDF]

Sci Rep, 2017
AbstractSpore-forming bacteria are a class of microorganisms that possess the ability to survive in extreme environmental conditions. Morphological features of spores assure their resistance to stress factors such as high temperature, radiation, disinfectants, and drying.
Piktel E, Pogoda K, Roman M, Niemirowicz K, Tokajuk G, Wróblewska M, Szynaka B, Kwiatek WM, Savage PB, Bucki R.   +9 more
europepmc   +4 more sources

Bactericidal Activity of Ceragenin CSA-13 in Cell Culture and in an Animal Model of Peritoneal Infection. [PDF]

Antimicrob Agents Chemother, 2015
ABSTRACTCeragenins constitute a novel family of cationic antibiotics characterized by a broad spectrum of antimicrobial activities, which have mostly been assessedin vitro. Using a polarized human lung epithelial cell culture system, we evaluated the antibacterial activities of the ceragenin CSA-13 against two strains ofPseudomonas aeruginosa(PAO1 and ...
Bucki R, Niemirowicz K, Wnorowska U, Byfield FJ, Piktel E, Wątek M, Janmey PA, Savage PB.   +7 more
europepmc   +4 more sources

Lysozyme increases bactericidal activity of ceragenin CSA-13 against Bacillus subtilis

Studia Medyczne, 2019
Wprowadzenie Bacillus subtilis oraz inne oportunistyczne laseczki odpowiadają za infekcje bakteryjne występujące ze względnie niską częstością, ale skutkujące poważnymi powikłaniami zdrowotnymi. Do tej grupy zalicza się przede wszystkim pooperacyjne i pourazowe zapalenie wnętrza gałki ocznej.
Bonita Durnaś, Krzysztof Fiedoruk, Mateusz Cieśluk, Piotr Deptuła, Grzegorz Król, Ewelina Piktel, Paul B. Savage, Robert Bucki   +7 more
doaj   +2 more sources

In vitro Activities of the Novel Ceragenin CSA-13, Alone or in Combination with Colistin, Tobramycin, and Ciprofloxacin, against Pseudomonas aeruginosa Strains Isolated from Cystic Fibrosis Patients

Chemotherapy, 2011
Background: The rise in the rates of antibiotic resistance among Pseudomonas aeruginosa strains from cystic fibrosis (CF) patients is concerning and underscores the need for the development of novel compounds.
Bozkurt-Guzel, Cagla, SAVAGE, Paul B., Gerceker, Ayse Alev   +2 more
core   +3 more sources