Results 41 to 50 of about 418 (139)

Antimicrobial Finish of Polyethersulfone Membranes: Sticking Photosensitizers‐Like Marine Mussels Would Do

Advanced Engineering Materials, Volume 25, Issue 6, March 2023., 2023
A chlorin‐based photosensitizer, known from photodynamic therapy, is derivatized to realize antimicrobial finishes for water‐filtration membranes. The introduced catechol moieties known from adhesive systems of marine mussels, improve the coating and affect both positioning and packing of the photosensitizers, to retain singlet oxygen production ...
Anna Grafl, Alexander Müller, Annegret Preuß, Beate Röder, Hans. G. Börner   +4 more
wiley   +1 more source

Macromolecular Coatings for Endotracheal Tubes Probed on An Ex Vivo Extubation Setup

Advanced Materials Interfaces, Volume 10, Issue 6, February 23, 2023., 2023
Endotracheal intubation is indispensable for many surgical and medical interventions. However, patients often suffer from intubation‐induced damage to the tissue and biofouling events occurring on the surfaces of endotracheal tubes. Here, modifications to the tube surface are applied that enhance its wettability and its resistance to biofouling while ...
Bernardo Miller Naranjo, Semai Naicker, Oliver Lieleg   +2 more
wiley   +1 more source

Multidrug‐Resistant Bacteria: Their Mechanism of Action and Prophylaxis

BioMed Research International, Volume 2022, Issue 1, 2022., 2022
In the present scenario, resistance to antibiotics is one of the crucial issues related to public health. Earlier, such resistance to antibiotics was limited to nosocomial infections, but it has now become a common phenomenon. Several factors, like extensive development, overexploitation of antibiotics, excessive application of broad‐spectrum drugs ...
Alok Bharadwaj, Amisha Rastogi, Swadha Pandey, Saurabh Gupta, Jagdip Singh Sohal, Sanket Kaushik   +5 more
wiley   +1 more source

Bactericidal Properties of Rod-, Peanut-, and Star-Shaped Gold Nanoparticles Coated with Ceragenin CSA-131 against Multidrug-Resistant Bacterial Strains

Pharmaceutics, 2021
Background: The ever-growing number of infections caused by multidrug-resistant (MDR) bacterial strains requires an increased effort to develop new antibiotics.
Sylwia Joanna Chmielewska, Karol Skłodowski, Joanna Depciuch, Piotr Deptuła, Ewelina Piktel, Krzysztof Fiedoruk, Patrycja Kot, Paulina Paprocka, Kamila Fortunka, Tomasz Wollny, Przemysław Wolak, Magdalena Parlinska-Wojtan, Paul B. Savage, Robert Bucki   +13 more
doaj   +1 more source

Synergistic Activity of Ceragenins Against Carbapenem-Resistant Acinetobacter baumannii Strains in Both Checkerboard and Dynamic Time-Kill Assays. [PDF]

Curr Microbiol, 2020
Acinetobacter baumannii is an emerging opportunistic pathogen that primarily infects critically ill patients in nosocomial settings and there is a need for identifying new alternative therapeutic agents against these organisms. Ceragenins are non-peptide,
Bozkurt-Guzel C, Inci G, Oyardi O, Savage PB.   +3 more
europepmc   +3 more sources

Ceragenins: A Class of Antiviral Compounds to Treat Orthopox Infections [PDF]

Journal of Investigative Dermatology, 2009
Eczema vaccinatum is a potentially fatal, disseminated viral skin infection that develops in individuals with atopic dermatitis after exposure to the vaccinia virus (VV). Despite advances in modern medicine, there are few options for those suffering from disseminated VV infections.
Howell, Michael D., Streib, Joanne E., Kim, Byung Eui, Lesley, Leighann J., Dunlap, Annegret P., Geng, Dianliang, Feng, Yanshu, Savage, Paul B., Leung, Donald Y.M.   +8 more
openaire   +2 more sources

Use of ceragenins to create novel biofouling resistant water-treatment membranes. [PDF]

, 2008
Scoping studies have demonstrated that ceragenins, when linked to water-treatment membranes have the potential to create biofouling resistant water-treatment membranes.
Savage, Paul B. (Brigham Young University, Provo, UT), Sanchez, Andres L. (LMATA, Albuquerque, NM), Fellows, Benjamin D., Jones, Howland D. T., Feng, Yanshu (Brigham Young University, Provo, UT), Hibbs, Michael R., Altman, Susan Jeanne, Pollard, Jacob (Brigham Young University, Provo, UT), McGrath, Lucas K. (LMATA, Albuquerque, NM)   +8 more
core   +1 more source

Antibacterial and Antibiofilm Activities of Ceragenins Alone and in Combination with Levofloxacin Against Multidrug Resistant Myroides spp. Clinical Isolates from Patients with Urinary Tract Infections [PDF]

, 2023
Myroides spp. are rare opportunistic pathogens, but they can be life-threatening because of their multidrug-resistant drug properties and their potential to cause outbreaks, especially in immunosuppressed patients.
Alkan, Busra, Savage, Paul B. B., Akcali, Alper, Eltimur, Tuba, Demir, Elif Sena, Bozkurt-Güzel, Çağla, Oyardi, Özlem, Savage, Paul B, Oyardı, Özlem, Alper Akçalı, Akçalı, Alper, Savage, Paul B.   +11 more
core   +1 more source

Design, synthesis, antimicrobial activity, stability, and mechanism of action of bioresorbable ceragenins. [PDF]

RSC Med Chem
Design, synthesis and characterization of bioresorbable ceragenins as potent and broad-spectrum antimicrobial agents.
Gubler S, Zaugg A, Yi R, Sherren E, Milner E, Conyer W, May T, Jack T, Heaton T, Christopherson J, Higbee P, Powers E, Takara M, Linder A, Boyack B, Pauga F, Salmon M, Thomas M, Shiraki M, Deng S, Savage PB.   +20 more
europepmc   +4 more sources

Ceragenins as Mimics of Endogenous Antimicrobial Peptides

Journal of Antimicrobial Agents, 2017
Ceragenins are small molecule mimics of endogenous antimicrobial peptides (AMPs), and as such display broadspectrum antimicrobial activity. These molecules are derived from a common bile acid and can be prepared at a large scale. Because ceragenins are not peptide based, they are not substrates for proteases.
Marjan M Hashemi, Brett S Holden, Bonita DurnaAA, Robert Buck, Paul B Savage   +4 more
openaire   +1 more source