Results 61 to 70 of about 418 (139)

Antimicrobial Peptides: A Promising Alternative to Conventional Antimicrobials for Combating Polymicrobial Biofilms

Advanced Science, Volume 12, Issue 1, January 9, 2025.
Antimicrobial peptides (AMPs) are promising alternatives to conventional treatments for polymicrobial biofilms, which increase pathogen resistance. AMPs disrupt biofilm extracellular matrices and microbial membranes, inhibiting biofilm formation and enhancing antibiotic efficacy. Current research addresses challenges like stability and production costs
Cesar Augusto Roque‐Borda, Laura Maria Duran Gleriani Primo, Kaila Petronila Medina‐Alarcón, Isabella C. Campos, Camila de Fátima Nascimento, Mauro M. S. Saraiva, Angelo Berchieri Junior, Ana Marisa Fusco‐Almeida, Maria José Soares Mendes‐Giannini, João Perdigão, Fernando Rogério Pavan, Fernando Albericio   +11 more
wiley   +1 more source

Tackling catheter‐associated urinary tract infections with next‐generation antimicrobial technologies

Journal of Biomedical Materials Research Part A, Volume 112, Issue 3, Page 312-335, March 2024.
Abstract Urinary catheters and other medical devices associated with the urinary tract such as stents are major contributors to nosocomial urinary tract infections (UTIs) as they provide an access path for pathogens to enter the bladder. Considering that catheter‐associated urinary tract infections (CAUTIs) account for approximately 75% of UTIs and ...
Lina Duque‐Sanchez, Yue Qu, Nicolas H. Voelcker, Helmut Thissen   +3 more
wiley   +1 more source

Antibacterial Plasma Polymer Coatings on 3D Materials for Orthopedic Applications

Advanced Materials Interfaces, Volume 11, Issue 2, January 16, 2024.
A plasma‐based technology to create anti‐infection bone implants is introduced. It enables the creation of robust coatings rich in radicals, facilitating strong attachment of antimicrobial agents through covalent bonding. The solvent‐free biofunctionalization, tailored for 3D materials, streamlines functional biomaterial fabrication.
Aiken Dao, Christale Gaitanos, Sumedh Kamble, Omid Sharifahmadian, Richard Tan, Steven G. Wise, Tiffany Lai Yun Cheung, Marcela M.M. Bilek, Paul B. Savage, Aaron Schindeler, Behnam Akhavan   +10 more
wiley   +1 more source

Quantification of Synergistic Effects of Ceragenin CSA-131 Combined with Iron Oxide Magnetic Nanoparticles Against Cancer Cells [Corrigendum]

International Journal of Nanomedicine, 2023
Piktel E, Markiewicz KH, Wilczewska AZ, et al. Int J Nanomedicine. 2020;15:4573–4589. It has been brought to the authors attention that Figure 6E showing nanosystem-mediated DNA fragmentation in DLD-1 colorectal cancer cells is a duplicate of part
Piktel E, Markiewicz KH, Wilczewska AZ, Daniluk T, Chmielewska S, Niemirowicz-Laskowska K, Mystkowska J, Paprocka P, Savage PB, Bucki R   +9 more
doaj  

Role of the HefC efflux pump in Helicobacter pylori cholesteroldependent resistance to ceragenins and bile salts

, 2011
The human gastric pathogen Helicobacter pylori modifies host cholesterol via glycosylation and incorporates the glycosylated cholesterol into its membrane; however, the benefits of cholesterol to H. pylori are largely unknown.
Katherine E. Horton, Paul B. Savage, Traci L. Testerman, Elizabeth A. Trainor, David J. Mcgee   +4 more
core   +1 more source

Optimization of Ceragenins for Prevention of Bacterial Colonization of Hydrogel Contact Lenses

Investigative Opthalmology & Visual Science, 2013
We provided contact lens hydrogels with an antibacterial innate immune function using nonpeptide mimics of endogenous antimicrobial peptides.Antimicrobial peptide mimics, ceragenins, were prepared for either covalent attachment to hydrogels or for controlled elution from lenses.
Xiaobo, Gu, Jacob D, Jennings, Jason, Snarr, Vinod, Chaudhary, Jacob E, Pollard, Paul B, Savage   +5 more
openaire   +2 more sources

Antibiofilm activities of ceragenins and antimicrobial peptides against fungal-bacterial mono and multispecies biofilms

, 2020
Multispecies biofilms, in which both fungus and bacteria species can be present, play a significant role in persistent infections, and new therapeutic options are needed against them. In this study, the activities of ceragenins and antimicrobial peptides
Bozkurt-Guzel, Cagla, Oyardı, Özlem, Hacıoğlu, Mayram, Savage, Paul B.   +3 more
core   +2 more sources

Preparation of Divalent and Trivalent Antigens for Immunogical Studies on Degranulation of Mast Cells and Preparation of Ceragenins for Antiviral Studies Against Vaccinia Virus. [PDF]

, 2007
CHAPTER 1 Aggregation of receptors for IgE (Fc RI) causes mast cells and basophils to release preformed contents of granules, including histamine and a variety of enzymes.
Geng, Dianliang
core  

Quantification of Synergistic Effects of Ceragenin CSA-131 Combined with Iron Oxide Magnetic Nanoparticles Against Cancer Cells

International Journal of Nanomedicine, 2020
Ewelina Piktel,1 Karolina H Markiewicz,2 Agnieszka Z Wilczewska,2 Tamara Daniluk,1 Sylwia Chmielewska,1 Katarzyna Niemirowicz-Laskowska,1 Joanna Mystkowska,3 Paulina Paprocka,4 Paul B Savage,5 Robert Bucki1,4 1Department of Medical Microbiology and ...
Piktel E, Markiewicz KH, Wilczewska AZ, Daniluk T, Chmielewska S, Niemirowicz-Laskowska K, Mystkowska J, Paprocka P, Savage PB, Bucki R   +9 more
doaj  

Ceragenin Nanogel Coating Prevents Biofilms Formation on Urinary Catheters

ACS Applied Materials & Interfaces
Catheter-associated urinary tract infections (CAUTIs) account for 40% of hospital-acquired infections, increasing health risks, patient discomfort, morbidity, and hospitalisation time. Bacterial colonisation may occur both during catheter insertion and prolonged catheterization by microorganisms in the urinary tract, consequently, increasing the ...
Antonio Puertas-Segura, Antonio Laganá, Garima Rathee, Paul Savage, Katerina Todorova, Petar Dimitrov, Iva Pashkuleva, Rui Luís Reis, Gianluca Ciardelli, Tzanko Tzanov   +9 more
openaire   +7 more sources