Results 51 to 60 of about 418 (139)

Bactericidal activity and biocompatibility of ceragenin-coated magnetic nanoparticles [PDF]

Journal of Nanobiotechnology, 2015
Ceragenins, synthetic mimics of endogenous antibacterial peptides, are promising candidate antimicrobial agents. However, in some settings their strong bactericidal activity is associated with toxicity towards host cells. To modulate ceragenin CSA-13 antibacterial activity and biocompatibility, CSA-13-coated magnetic nanoparticles (MNP-CSA-13) were ...
Katarzyna Niemirowicz, Urszula Wnorowska, Wilczewska, Agnieszka, Mystkowska, Joanna, Ewelina Piktel, Gu, Xiaobo, Zbigniew Namiot, Alina Kułakowska, Savage, Paul, Robert Bucki   +9 more
openaire   +2 more sources

Surfactants: Role in biofilm management and cellular behaviour

International Wound Journal, Volume 16, Issue 3, Page 753-760, June 2019., 2019
Appropriate and effective wound cleaning represents an important process that is necessary for preparing the wound for improved wound healing and for helping to dislodge biofilms. Wound cleaning is of paramount importance to wound bed preparation for helping to enhance wound healing. Surfactant applications in wound care may represent an important area
Steven L. Percival, Dieter Mayer, Robert S. Kirsner, Greg Schultz, Dot Weir, Sashwati Roy, Afsaneh Alavi, Marco Romanelli   +7 more
wiley   +1 more source

In vitro evaluation of the potential for resistance development to ceragenin CSA-13 [PDF]

Journal of Antimicrobial Chemotherapy, 2012
Though most bacteria remain susceptible to endogenous antimicrobial peptides, specific resistance mechanisms are known. As mimics of antimicrobial peptides, ceragenins were expected to retain antibacterial activity against Gram-positive and -negative bacteria, even after prolonged exposure.
Jake E, Pollard, Jason, Snarr, Vinod, Chaudhary, Jacob D, Jennings, Hannah, Shaw, Bobbie, Christiansen, Jonathan, Wright, Wenyi, Jia, Russell E, Bishop, Paul B, Savage   +9 more
openaire   +2 more sources

Recent Nanotechnology Approaches for Prevention and Treatment of Biofilm‐Associated Infections on Medical Devices

BioMed Research International, Volume 2016, Issue 1, 2016., 2016
Bacterial colonization in the form of biofilms on surfaces causes persistent infections and is an issue of considerable concern to healthcare providers. There is an urgent need for novel antimicrobial or antibiofilm surfaces and biomedical devices that provide protection against biofilm formation and planktonic pathogens, including antibiotic resistant
Mohankandhasamy Ramasamy, Jintae Lee, Ariel Kushmaro   +2 more
wiley   +1 more source

Potential Synergy Activity of the Novel Ceragenin, CSA‐13, against Carbapenem‐Resistant Acinetobacter baumannii Strains Isolated from Bacteremia Patients

BioMed Research International, Volume 2014, Issue 1, 2014., 2014
Carbapenem‐resistant Acinetobacter baumannii is an important cause of nosocomial infections, particularly in patients in the intensive care units. As chronic infections are difficult to treat, attempts have been made to discover new antimicrobials. Ceragenins, designed to mimic the activities of antimicrobial peptides, are a new class of antimicrobial ...
Cagla Bozkurt-Guzel, Paul B. Savage, Alper Akcali, Berna Ozbek-Celik, Ketoki Kapila   +4 more
wiley   +1 more source

Susceptibility of Multidrug-Resistant Bacteria, Isolated from Water and Plants in Nigeria, to Ceragenins

, 2018
The continuous emergence of multidrug resistant pathogens is a major global health concern. Although antimicrobial peptides (AMPs) have shown promise as a possible means of combatting multidrug resistant strains without readily engendering resistance ...
Jordan Coburn, John Wilson, Maddison Taylor, Shenglou Deng, Darius Baradaran, Paul Savage, Joseph Reiley, Brett Holden, Marjan Hashemi, Tania Stenquist, Augusta Mmuoegbulam   +10 more
core   +1 more source

New β-Lactam Antibiotics and Ceragenins – A Study to Assess Their Potential in Treatment of Infections Caused by Multidrug-Resistant Strains of Pseudomonas aeruginosa

Infection and Drug Resistance, 2021
Paulina Paprocka,1 Bonita Durnaś,1,2 Angelika Mańkowska,1 Karol Skłodowski,3 Grzegorz Król,1 Magdalena Zakrzewska,3 Michał Czarnowski,3 Patrycja Kot,1 Kamila Fortunka,1 Stanisław Góźdź,2 Paul B Savage,4 ...
Paprocka P, Durnaś B, Mańkowska A, Skłodowski K, Król G, Zakrzewska M, Czarnowski M, Kot P, Fortunka K, Góźdź S, Savage PB, Bucki R   +11 more
doaj  

Ceragenin‐Loaded Tri‐Layered Skin Substitute Composed of Natural and Synthetic Biopolymers for Burn Wound Healing

Journal of Biomedical Materials Research Part A, Volume 114, Issue 6, June 2026.
ABSTRACT Burn wounds present significant clinical challenges due to high infection risk, delayed healing, and extensive tissue damage. The development of biomimetic skin substitutes capable of simultaneously supporting tissue regeneration and preventing infection remains a critical need in burn wound management. In this study, a novel ceragenin (CSA‐44)
Nawal Aljayyousi, Emel Tamahkar Irmak, Esra Karaca, Elif Tümay Özer, Oğuzhan Akgün, Ferda Arı, Aycan Yiğit Çınar, Çağla Bozkurt Güzel, Paul B. Savage, Bilgen Osman   +9 more
wiley   +1 more source

Impact of Lipophilicity‐Tuning on the Antimicrobial Activity of a Series of β‐Face–Expanding Bile Acid Derivatives

BioMed Research International, Volume 2026, Issue 1, 2026.
The increasing prevalence of antimicrobial resistance has stimulated the search for new molecular scaffolds with improved efficacy and selectivity. In this study, five bile acid–derived aminosteroids (AC series) and their corresponding biphenyl‐functionalized derivatives (BIAC series) were synthesized and evaluated against Staphylococcus aureus and ...
Allan Mora Abarca, Luis Rivera-Montero, Kenia Barrantes, Victor H. Soto-Tellini, William J. Zamora, Baisakhi Banerjee   +5 more
wiley   +1 more source

Translation of ceragenin affinity for bacteria to an imaging reagent for infection

RSC Advances, 2019
Infection imaged via autoradiography with ceragenin conjugated to a copper radiolabel.
Nilantha Bandara, Yubo Li, Philipp Diebolder, Cedric Mpoy, Xiaobo Gu, Pitambar Khanal, Shenglou Deng, Buck E. Rogers, Paul B. Savage   +8 more
openaire   +3 more sources