Results 31 to 40 of about 418 (139)

Nanoantibiotics containing membrane-active human cathelicidin LL-37 or synthetic ceragenins attached to the surface of magnetic nanoparticles as novel and innovative therapeutic tools: current status and potential future applications [PDF]

Journal of Nanobiotechnology, 2020
Nanotechnology-based therapeutic approaches have attracted attention of scientists, in particular due to the special features of nanomaterials, such as adequate biocompatibility, ability to improve therapeutic efficiency of incorporated drugs and to ...
Urszula Wnorowska, Krzysztof Fiedoruk, Ewelina Piktel, Suhanya V. Prasad, Magdalena Sulik, Marianna Janion, Tamara Daniluk, Paul B. Savage, Robert Bucki   +8 more
doaj   +2 more sources

Recent advances in the therapeutic potential of cathelicidins [PDF]

Frontiers in Microbiology
The alarming increase in antimicrobial resistance in the last decades has prompted the search for alternatives to control infectious diseases. Antimicrobial peptides (AMPs) represent a heterogeneous class of molecules with ample antibacterial, antiviral,
Maria Eduarda Souza Guerra, Brenda Vieira, Ana Paula Carvalho Thiers Calazans, Giulia Vicente Destro, Karina Melo, Emilly Rodrigues, Natalha Tedeschi Waz, Raquel Girardello, Michelle Darrieux, Thiago Rojas Converso   +9 more
doaj   +2 more sources

Ceragenin-coated endotracheal tubes for the reduction of ventilator-associated pneumonia: a prospective, longitudinal, cross-over, interrupted time, implementation study protocol (CEASE VAP study) [PDF]

BMJ Open
Background Critically ill patients are at high risk of acquiring ventilator-associated pneumonia (VAP), which occurs in approximately 20% of mechanically ventilated patients.
John Muscedere, Andrew Day, David M Maslove, Joanna S Semrau, John Gordon Boyd, Stephanie Sibley, Tracy Boyd, Patrick A Norman, Nicola E Symonds, Eric X M Meng, Hailey Hobbs   +10 more
doaj   +2 more sources

In vitro activities of antimicrobial peptides and ceragenins against Legionella pneumophila

The Journal of Antibiotics, 2019
Legionella pneumophila is a waterborne intracellular pathogenic bacterium, the most frequent cause of human legionellosis and a relatively common cause of community-acquired and nosocomial pneumonia.
Zuhal Zeybek, Paul B. Savage, SAVAGE, Paul B., Bozkurt-Guzel, Çağla, Zeybek, Zuhal, Hacioglu, MAYRAM, A. Seher Birteksoz-Tan, Birteksoz-Tan, Ayşe Seher, Mayram Hacioglu, Cagla Bozkurt-Guzel   +9 more
core   +3 more sources

Sporicidal activity of ceragenin CSA-13 against Bacillus subtilis [PDF]

Scientific Reports, 2017
Spore-forming bacteria are a class of microorganisms that possess the ability to survive in extreme environmental conditions. Morphological features of spores assure their resistance to stress factors such as high temperature, radiation, disinfectants ...
Maciej Roman, Wojciech M. Kwiatek, Grażyna Tokajuk, Paul B. Savage, Katarzyna Pogoda, Katarzyna Niemirowicz, Marta Wróblewska, Beata Szynaka, Ewelina Piktel, Robert Bucki   +9 more
core   +3 more sources

Preparation, Characterization, and Antimicrobial Activities of Ceragenins Incorporated Into Polyvinyl Alcohol/Gelatin/Sodium Alginate‐Based Hydrogels for Treatment of Burn Wounds

Journal of Applied Polymer Science, Volume 142, Issue 27, July 15, 2025.
ABSTRACT Ceragenins are synthetic molecules that mimic antimicrobial peptides (AMPs) in the human immune system. They feature a bile acid‐based structure with appended positively charged groups that disrupt bacterial cell membranes, leading to microbial cell death or inactivation.
Nawal Aljayyousi, Emel Tamahkar Irmak, Elif Tümay Özer, Aycan Yiğit Çınar, Çağla Bozkurt Güzel, Paul B. Savage, Bilgen Osman   +6 more
wiley   +2 more sources

Antibacterial and Antifungal Activities of Poloxamer Micelles Containing Ceragenin CSA-131 on Ciliated Tissues

Molecules, 2018
Ceragenins were designed as non-peptide mimics of endogenous antimicrobial peptides, and they display broad-spectrum antibacterial and antifungal activities, including the ability to eradicate established biofilms.
Marjan M. Hashemi, Brett S. Holden, Maddison F. Taylor, John Wilson, Jordan Coburn, Brian Hilton, Tania Nance, Shawn Gubler, Carl Genberg, Shenglou Deng, Paul B. Savage   +10 more
doaj   +2 more sources

Core–shell magnetic nanoparticles display synergistic antibacterial effects against Pseudomonas aeruginosa and Staphylococcus aureus when combined with cathelicidin LL-37 or selected ceragenins

International Journal of Nanomedicine, 2016
Katarzyna Niemirowicz,1 Ewelina Piktel,1 Agnieszka Z Wilczewska,2 Karolina H Markiewicz,2 Bonita Durnaś,3 Marzena Wątek,4 Irena Puszkarz,3 Marta Wróblewska,5,6 Wieslawa Niklińska,7 Paul B Savage,8 Robert Bucki1,3 1Department of Microbiological ...
Niemirowicz K, Piktel E, Wilczewska AZ, Markiewicz KH, Durnaś B, Wątek M, Puszkarz I, Wróblewska M, Niklińska W, Savage PB, Bucki R   +10 more
doaj   +1 more source

Investigating the Effectiveness of Ceragenins against <i>Acinetobacter baumannii</i> to Develop New Antimicrobial and Anti-Adhesive Strategies. [PDF]

Int J Mol Sci
A growing body of experimental data indicates that ceragenins (CSAs), which mimic the physicochemical properties of the host’s cationic antimicrobial peptide, hold promise for the development of a new group of broad-spectrum antimicrobials.
Karasiński M, Wnorowska U, Daniluk T, Deptuła P, Łuckiewicz M, Paprocka P, Durnaś B, Skłodowski K, Sawczuk B, Savage PB, Piktel E, Bucki R.   +11 more
europepmc   +2 more sources

Antibacterial and Antibiofilm Activities of Ceragenins against Pseudomonas aeruginosa Clinical Isolates. [PDF]

Turk J Pharm Sci, 2019
Objectives: Pseudomonas aeruginosa can cause life-threatening infections that are difficult to treat due to its high resistance to antibiotics and its ability to form antibiotic tolerant biofilms.
Bozkurt Güzel Ç, Hacioğlu M, Inci G, Savage PB.   +3 more
europepmc   +2 more sources