Ceragenins Prevent the Development of Murine Vaginal Infection Caused by Gardnerella vaginalis [PDF]
PharmaceuticalsBackground/Objectives: Bacterial vaginosis (BV), an infection caused primarily by Gardnerella vaginalis, is the most prevalent vaginal infection.
Urszula Wnorowska +6 more
doaj +5 more sources
Use of ceragenins as a potential treatment for urinary tract infections [PDF]
BMC Infectious Diseases, 2019 Background Urinary tract infections (UTIs) are one of the most common bacterial infections. High recurrence rates and the increasing antibiotic resistance among uropathogens constitute a large social and economic problem in current public health.
Urszula Wnorowska +5 more
doaj +7 more sources
Effects of Ceragenins and Antimicrobial Peptides on the A549 Cell Line and an In Vitro Co-Culture Model of A549 Cells and Pseudomonas aeruginosa [PDF]
Pathogens, 2022 Pseudomonas aeruginosa is an important pathogen that can adhere to host tissues and epithelial surfaces, especially during chronic infections such as cystic fibrosis (CF) lung infections.
Ozlem Oyardi +2 more
doaj +4 more sources
Comparative In Vitro Activities of First and Second-Generation Ceragenins Alone and in Combination with Antibiotics Against Multidrug-Resistant Klebsiella pneumoniae Strains [PDF]
Antibiotics, 2019 Objectives: The ceragenins, or CSAs, were designed to mimic the activities of antimicrobial peptides and represent a new class of antimicrobial agent.
Berna Ozbek-Celik +4 more
doaj +3 more sources
Bactericidal Activity of Ceragenin in Combination with Ceftazidime, Levofloxacin, Co-Trimoxazole, and Colistin against the Opportunistic Pathogen Stenotrophomonas maltophilia [PDF]
Pathogens, 2022 Background: Stenotrophomonas maltophilia (S. maltophilia) is an emerging opportunistic Gram-negative rod causing nosocomial infections predominantly in immunocompromised patients.
Paulina Paprocka +9 more
doaj +3 more sources
Ceragenin-mediated disruption of Pseudomonas aeruginosa biofilms. [PDF]
PLoS ONEBackgroundMicrobial biofilms, as a hallmark of cystic fibrosis (CF) lung disease and other chronic infections, remain a desirable target for antimicrobial therapy.
Urszula Wnorowska +11 more
doaj +5 more sources
Ceragenin-Coated Non-Spherical Gold Nanoparticles as Novel Candidacidal Agents [PDF]
Pharmaceutics, 2021 Background: Infections caused by Candida spp. have become one of the major causes of morbidity and mortality in immunocompromised patients. Therefore, new effective fungicides are urgently needed, especially due to an escalating resistance crisis ...
Karol Skłodowski +12 more
doaj +5 more sources
Assessment of Ceragenins in Prevention of Damage to Voice Prostheses Caused by Candida Biofilm Formation [PDF]
Pathogens, 2021 This study aimed to investigate the potential application of ceragenins (CSAs) as new candidacidal agents to prevent biofilm formation on voice prostheses (VPs).
Jakub Spałek +14 more
doaj +3 more sources
Antimicrobial ceragenins inhibit biofilms and affect mammalian cell viability and migration in vitro [PDF]
FEBS Open Bio, 2017 The healing of burn wounds is often hampered by bacterial infection and the formation of biofilms. Antimicrobial peptides (AMPs) are effective in promoting wound healing, but are susceptible to degradation. We have tested the ability of ceragenins (CSAs),
Melissa A. Olekson +3 more
doaj +4 more sources
Ceragenins exhibiting promising antimicrobial activity against various multidrug resistant Gram negative bacteria [PDF]
Journal of Parasitology, 2018 Ceragenins are novel promising agents for the treatment of infections caused by multi-drug resistant microorganisms. Since colistin resistance has become a worldwide problem, the need for new treatment agents has been increasing steadily. Therefore, this
AKÇALI, ALPER +5 more
core +4 more sources