Magnetic nanoparticles enhance the anticancer activity of cathelicidin LL-37 peptide against colon cancer cells [PDF]
International Journal of Nanomedicine, 2015 Katarzyna Niemirowicz,1 Izabela Prokop,2 Agnieszka Z Wilczewska,3 Urszula Wnorowska,1 Ewelina Piktel,1 Marzena Wątek,4 Paul B Savage,5 Robert Bucki1,6 1Department of Microbiological and Nanobiomedical Engineering, Medical University of Bialystok ...
Niemirowicz K +7 more
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SP-LL-37, human antimicrobial peptide, enhances disease resistance in transgenic rice. [PDF]
PLoS ONE, 2017 Human LL-37 is a multifunctional antimicrobial peptide of cathelicidin family. It has been shown in recent studies that it can serve as a host's defense against influenza A virus.
In Hye Lee +6 more
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Antibiofilm Activity of LL-37 Peptide and D-Amino Acids Associated with Antibiotics Used in Regenerative Endodontics on an Ex Vivo Multispecies Biofilm Model [PDF]
Life, 2022 The antimicrobial peptide LL-37 and D-amino acids (D-AAs) have been proposed as antibiofilm agents. Therefore, this study aimed to test the antimicrobial effect of antibiofilm agents associated with antibiotics used in regenerative endodontic procedures (
Ana C. C. Pereira +7 more
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Chitosan hydrogel encapsulated with LL-37 peptide promotes deep tissue injury healing in a mouse model [PDF]
Military Medical Research, 2020 Background LL-37 peptide is a member of the human cathelicidin family, and has been shown to promote the healing of pressure ulcers. However, the low stability of this peptide within the wound environment limits its clinical use.
Xu Yang +7 more
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Human cathelicidin peptide LL-37 compacts nucleic acids and alters neutrophil extracellular trap structure [PDF]
Scientific ReportsThe human cathelicidin host defense peptide LL-37 is expressed by many cell types, including neutrophils, macrophages, and epithelial cells, and forms complexes with nucleic acids that can have either beneficial or detrimental health effects.
Claudia Zielke +9 more
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LL‐37: Biological Mechanisms and Emerging Therapeutic Applications in Intestinal Disease [PDF]
Immunity, Inflammation and DiseaseHuman cathelicidin peptide LL‐37 is encoded by the CAMP gene and plays a key role in innate immunity. It maintains intestinal homeostasis through antibacterial, immunomodulation, and tissue repair functions.
Qichao Liu, Peng Xu, Cheng Zhang
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The Potential of Human Peptide LL-37 as an Antimicrobial and Anti-Biofilm Agent
Antibiotics, 2021 The rise in antimicrobial resistant bacteria threatens the current methods utilized to treat bacterial infections. The development of novel therapeutic agents is crucial in avoiding a post-antibiotic era and the associated deaths from antibiotic ...
Kylen E. Ridyard, Joerg Overhage
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Biochemistry and Biophysics Reports, 2022 The human antimicrobial peptide LL-37 permeabilizes the plasma membrane of host cells, but LL-37-induced direct effects on mitochondrial membrane permeability and function has not been reported.
Elisabeth Bankell +6 more
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Frontiers in Bioscience-Landmark, 2021 Human cathelicidin antimicrobial peptide LL-37 (LL-37) is an antimicrobial peptide derived from its precursor protein hCAP18, which is an only cathelicidin in human.
Keqiang Chen +4 more
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Characterizing the role of cell-wall β-1,3-exoglucanase Xog1p in Candida albicans adhesion by the human antimicrobial peptide LL-37. [PDF]
PLoS ONE, 2011 Candida albicans is the major fungal pathogen of humans. Its adhesion to host-cell surfaces is the first critical step during mucosal infection. Antimicrobial peptides play important roles in the first line of mucosal immunity against C.
Pei-Wen Tsai +3 more
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