Results 11 to 20 of about 57,467,955 (246)

Cathelicidin peptide LL-37: A multifunctional peptide involved in heart disease

Pharmacological Research
Heart disease is a common human disease with high morbidity and mortality. Timely and effective prevention and treatment is an urgent clinical problem.
Shuo Miao, Houde Liu, Qingyu Yang, Yaping Zhang, Tao Chen, Shuai Chen, Xin Mao, Qingsong Zhang   +7 more
doaj   +2 more sources

CXCR2 specific endocytosis of immunomodulatory peptide LL-37 in human monocytes and formation of LL-37 positive large vesicles in differentiated monoosteophils

Bone Reports, 2020
Immunomodulatory peptide cathelicidin/LL-37 induces human monocyte differentiation into a novel bone repair cell, the monoosteophil. We now demonstrate that LL-37 is endocytosed by monocytes over a period of 6 days producing large (10 × 2 μm ...
Zhifang Zhang, Keith Le, Deirdre La Placa, Brian Armstrong, Marcia M. Miller, John E. Shively   +5 more
doaj   +1 more source

Regulation of macrophage cell surface GAPDH alters LL-37 internalization and downstream effects in the cell

Journal of Innate Immunity, 2023
Mycobacterium tuberculosis (M.tb), the major causative agent of tuberculosis (TB), has evolved mechanisms to evade host defenses and persist within host cells.
Asmita Dhiman, Sharmila Talukdar, Gaurav Kumar Chaubey, Rahul Dilawari, Radheshyam Modanwal, Surbhi Chaudhary, Anil Patidar, Vishant Mahendra Boradia, Pradeep Kumbhar, Chaaya Iyengar Raje, Manoj Raje   +10 more
doaj   +1 more source

The Small Metal-Binding Protein SmbP Simplifies the Recombinant Expression and Purification of the Antimicrobial Peptide LL-37

Antibiotics, 2021
(1) Background: The cathelicidin peptide LL-37 is a prominent molecule with many biological activities, including antimicrobial. Due to its importance, here, we describe the production of LL-37 tagged with SmbP, a relatively new carrier protein that ...
David A. Perez-Perez, Teresa de J. Villanueva-Ramirez, Adriana E. Hernandez-Pedraza, Nestor G. Casillas-Vega, Patricia Gonzalez-Barranco, Xristo Zarate   +5 more
doaj   +1 more source

Does peri-implant bone loss affect the LL-37 and proteinase 3 levels in peri-implant sulcus fluid?

International Journal of Implant Dentistry, 2020
Background Inactive human cathelicidin antimicrobial peptide is present in neutrophils, and proteinase 3 activates this peptide by producing active LL-37 peptide. LL-37 acts as a defensive peptide in the oral tissues. In the present study, the aim was to
Oya Turkoglu, Candan Efeoglu, Harika Atmaca   +2 more
doaj   +1 more source

Identifying the Critical Domain of LL-37 Involved in Mediating Neutrophil Activation in the Presence of Influenza Virus: Functional and Structural Analysis. [PDF]

PLoS ONE, 2015
The human cathelicidin LL-37 has been shown to play a role in host defense against influenza A viruses (IAV) through direct antiviral effects and through modulating inflammatory responses to infection.
Shweta Tripathi, Guangshun Wang, Mitchell White, Michael Rynkiewicz, Barbara Seaton, Kevan Hartshorn   +5 more
doaj   +1 more source

Susceptibility of Pseudomonas aeruginosa biofilm to alpha-helical peptides: D-enantiomer of LL-37

Frontiers in Cellular and Infection Microbiology, 2011
Pseudomonas aeruginosa is a highly versatile opportunistic pathogen and its ability to produce biofilms is a direct impediment to the healing of wounds and recovery from infection.
Scott N. Dean, Barney M. Bishop, Monique L Van Hoek   +2 more
doaj   +1 more source

Comparison of Antibacterial Effect of Cationic Peptide LL‐37 and Cefalexin on Clinical Staphylococcus aureus‐induced Infection after Femur Fracture Fixation

Orthopaedic Surgery, 2020
Objective Antimicrobial peptides are widely present in nature, with many of the antimicrobial peptides having antimicrobial activity against Gram‐positive and Gram‐negative bacteria, fungi, parasites, and even coated viruses.
Cheng‐yuan Yan, Yu‐zhou Liu, Zhong‐hua Xu, Hao‐yu Yang, Jin Li   +4 more
doaj   +1 more source

LL-37 induces polymerization and bundling of actin and affects actin structure. [PDF]

PLoS ONE, 2012
Actin exists as a monomer (G-actin) which can be polymerized to filaments) F-actin) that under the influence of actin-binding proteins and polycations bundle and contribute to the formation of the cytoskeleton.
Asaf Sol, Edna Blotnick, Gilad Bachrach, Andras Muhlrad   +3 more
doaj   +1 more source

Salivary concentration of the antimicrobial peptide LL-37 in patients with oral lichen planus

Journal of Oral Microbiology, 2014
Background: The antimicrobial peptide LL-37 is a significant molecule of innate immunity and recent studies indicate that it plays an important role in maintaining oral health.
Sotiria Davidopoulou, Haris Theodoridis, Konstantinos Nazer, Eftichia Kessopoulou, George Menexes, Sotirios Kalfas   +5 more
doaj   +1 more source