Gut Microbes, 2020 We hypothesized that the antimicrobial peptide cathelicidin has a physiological role in regulating gut inflammatory homeostasis. We determined that cathelicidin synergizes with LPS to facilitate its internalization and signaling via endosomic TLR4 in ...
Ravi Holani +2 more
exaly +2 more sources
Detection of Cathelicidin-1 and Cathelicidin-2 Biomolecules in the Milk of Goats and Their Use as Biomarkers for the Diagnosis of Mastitis [PDF]
AnimalsThe objectives of the present work were as follows: (i) the detection of cathelicidin biomolecules in the milk of individual goats during the early stages of mastitis and their potential use for the diagnosis of mastitis at its early stage and (ii) the ...
Maria V. Bourganou +12 more
doaj +2 more sources
Cathelicidin Contributes to the Restriction of Leishmania in Human Host Macrophages
Frontiers in Immunology, 2019 In cutaneous Leishmaniasis the parasitic control in human host macrophages is still poorly understood. We found an increased expression of the human cathelicidin CAMP in skin lesions of Ethiopian patients with cutaneous leishmaniasis.
Birgitta Agerberth +2 more
exaly +3 more sources
Scientific Reports, 2018 Cathelicidins play pivotal roles in host defense. The discovery of novel cathelicidins is important research; however, despite the identification of many cathelicidins in vertebrates, few have been reported in amphibians.
Chunyun Wu, Xinwang Yang
exaly +2 more sources
Cathelicidin regulates goblet cell mucus secretion and mucus-associated proteins in Citrobacter rodentium-induced colitis [PDF]
Gut MicrobesColonic goblet cells play a crucial role in mucosal defense by secreting Muc2 mucin and other proteins that entrap and expel enteropathogens. However, the role of innate effectors in the gut like cathelicidin peptides in regulating the mucus barrier ...
Niloofar Mirzadzare +12 more
doaj +2 more sources
Beta-Lactamase Repressor BlaI Modulates Staphylococcus aureus Cathelicidin Antimicrobial Peptide Resistance and Virulence. [PDF]
, 2015 BlaI is a repressor of BlaZ, the beta-lactamase responsible for penicillin resistance in Staphylococcus aureus. Through screening a transposon library in S.
Gallo, Richard L +6 more
core +14 more sources
International Journal of Mycobacteriology, 2023 Background: The immunomodulatory effects of Vitamin D expand to induce the synthesis of an antimicrobial peptide, cathelicidin. There is evidence showing altered levels of cathelicidin in tuberculosis (TB).
Yuvaraj Balan +4 more
doaj +1 more source
The antimicrobial peptide cathelicidin protects mice from Escherichia coli O157:H7-mediated disease. [PDF]
PLoS ONE, 2012 This study investigated the role of the antimicrobial peptide cathelicidin in Escherichia coli O157:H7 infection and subsequent renal damage. Mouse and human cathelicidin, CRAMP and LL-37, respectively, killed E. coli O157:H7 in vitro.
Milan Chromek +2 more
doaj +1 more source
Snake cathelicidin from Bungarus fasciatus is a potent peptide antibiotics. [PDF]
PLoS ONE, 2008 BACKGROUND: Cathelicidins are a family of antimicrobial peptides acting as multifunctional effector molecules of innate immunity, which are firstly found in mammalians. Recently, several cathelicidins have also been found from chickens and fishes.
Yipeng Wang +8 more
doaj +1 more source
Immunomodulatory effects of chicken cathelicidin-2 on a primary hepatic cell co-culture model
PLoS ONE, 2022 Cathelicidin-2 is an antimicrobial peptide (AMP) produced as part of the innate immune system of chickens and might be a new candidate to combat infection and inflammation within the gut-liver axis.
Csilla Sebők +9 more
doaj +2 more sources