Results 31 to 40 of about 17,552 (216)

Antimicrobial peptide-producing dermal preadipocytes defend against Candida albicans skin infection via the FGFR-MEK-ERK pathway.

PLoS Pathogens, 2023
Dermal fibroblasts (dFBs) defend against deep bacterial skin infections by differentiating into preadipocytes (pAds) that produce the antimicrobial peptide cathelicidin; this differentiation is known as the dermal reactive adipogenesis response. However,
Jianing Wang, Zhimin Duan, Rong Zeng, Lu Yang, Weizhao Liu, Yiman Liu, Qian Yao, Xu Chen, Ling-Juan Zhang, Min Li   +9 more
doaj   +1 more source

Cathelicidin-DM is an Antimicrobial Peptide from Duttaphrynus melanostictus and Has Wound-Healing Therapeutic Potential

, 2020
Antimicrobial peptides (AMPs) are a class of templates with application potential for drug development. Amphibians are important sources of AMPs. Duttaphrynus melanostictus is the main source of traditional Chinese medicine “Chansu”, which has anti ...
Chao Li (145513), Zijun Chen (286584), Ying Luo (381053), A-Mei Zhang (157343), Yaoqiang Shi (8708502), Yi Sun (118759), Xue-shan Xia (8708505), Yuzhu Song (4379782), Mei Wang (130842)   +8 more
core   +1 more source

A cross sectional analysis of the role of the antimicrobial peptide cathelicidin in lung function impairment within the ALIVE cohort.

PLoS ONE, 2014
BackgroundVitamin D deficiency is associated with reduced lung function. Cathelicidin, an antimicrobial peptide regulated by vitamin D, plays a role within the innate immune system.
Allison A Lambert, Gregory D Kirk, Jacquie Astemborski, Enid R Neptune, Shruti H Mehta, Robert A Wise, M Bradley Drummond   +6 more
doaj   +1 more source

Antifungal Activity of Human Cathelicidin LL-37, a Membrane Disrupting Peptide, by Triggering Oxidative Stress and Cell Cycle Arrest in Candida auris

Journal of Fungi, 2022
Candida auris, an evolving multidrug-resistant pathogenic yeast, is known for causing severe invasive infections associated with high mortality rates in hospitalized individuals. Distinct from other Candida species, C.
Irfan A. Rather, Jamal S. M. Sabir, Amer H. Asseri, Sajad Ali   +3 more
doaj   +1 more source

Cathelicidins Modulate TLR-Activation and Inflammation [PDF]

Frontiers in Immunology, 2020
Cathelicidins are short cationic peptides that are part of the innate immune system. At first, these peptides were studied mostly for their direct antimicrobial killing capacity, but nowadays they are more and more appreciated for their immunomodulatory functions.
Maaike R. Scheenstra, Roel M. van Harten, Edwin J. A. Veldhuizen, Henk P. Haagsman, Maarten Coorens, Maarten Coorens   +5 more
openaire   +4 more sources

Evolution of the Primate Cathelicidin [PDF]

Journal of Biological Chemistry, 2006
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Zelezetsky, Igor, Pontillo, Alessandra, Puzzi, Luca, Antcheva, Nikolinka, Segat, Ludovica, Pacor, Sabrina, Crovella, Sergio, Tossi, Alessandro   +7 more
openaire   +2 more sources

Human Cathelicidin Production by the Cervix

PLoS ONE, 2014
hCAP18/LL-37 is the sole human cathelicidin; a family of host defence peptides with key roles in innate host defence. hCAP18/LL-37 is expressed primarily by neutrophils and epithelial cells, but its production and function in the lower genital tract is largely uncharacterised.
Frew, Lorraine, Makieva, Sofia, McKinlay, Andrew T M, McHugh, Brian J, Doust, Ann, Norman, Jane E, Davidson, Donald J, Stock, Sarah J   +7 more
openaire   +6 more sources

Influence of Vitamin D Deficiency on the Level of Salivary cathelicidin LL-37 in relation to Dental Caries Experience: A Case-Control Study

مجله كليه طب الكندي, 2023
Background: Vitamin D improves innate immunity by enhancing the expression of antimicrobial peptides. The antimicrobial action of cathelicidin is widespread and effective against cariogenic bacteria.
Narjes M. Alhelfi, Nibal M. Hobi
doaj   +1 more source

Plasma cathelicidin and longitudinal lung function in current and former smokers.

PLoS ONE, 2019
IntroductionCathelicidin (also known as LL-37 in humans) is an antimicrobial peptide secreted by epithelial and immune cells and regulated by vitamin D. The immunological roles of cathelicidin make it a putative biomarker to identify individuals at risk ...
Robert M Burkes, Jacquie Astemborski, Allison A Lambert, Todd T Brown, Robert A Wise, Gregory D Kirk, M Bradley Drummond   +6 more
doaj   +1 more source

The roles of vitamin D and cathelicidin in type 1 diabetes susceptibility

Endocrine Connections, 2021
Type 1 diabetes has an increasingly greater incidence and prevalence with no cure available. Vitamin D supplementation is well documented to reduce the risk of developing type 1 diabetes.
Cecília Cristelo, Alexandra Machado, Bruno Sarmento, Francisco Miguel Gama   +3 more
doaj   +1 more source