Results 11 to 20 of about 16,196 (213)
Differential cathelicidin expression in duodenal and gastric biopsies from Tanzanian and German patients. [PDF]
PLoS ONE, 2011 BackgroundEpithelial surfaces such as the gastrointestinal mucosa depend on expression of antimicrobial peptides like cathelicidin for immune defence against pathogens.
Dorothee Rogoll +4 more
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Antiviral Potential of Cathelicidins [PDF]
Future Microbiology, 2013 The global burden of morbidity and mortality arising from viral infections is high; however, the development of effective therapeutics has been slow. As our understanding of innate immunity has expanded over recent years, knowledge of natural host defenses against viral infections has started to offer potential for novel therapeutic strategies.
Barlow, Peter G. +3 more
openaire +5 more sources
Cathelicidin-BF, a snake cathelicidin-derived antimicrobial peptide, could be an excellent therapeutic agent for acne vulgaris. [PDF]
PLoS ONE, 2011 Cathelicidins are a family of antimicrobial peptides acting as multifunctional effector molecules in innate immunity. Cathelicidin-BF has been purified from the snake venoms of Bungarus fasciatus and it is the first identified cathelicidin antimicrobial ...
Yipeng Wang +9 more
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The neutrophil antimicrobial peptide cathelicidin promotes Th17 differentiation [PDF]
Nature Communications, 2021 Neutrophils secrete numerous immune effector molecules including cathelicidin which is associated with antimicrobial properties. Here the authors implicate neutrophil derived cathelicidin in modulation of CD4 T cell homoeostasis and the promotion of Th17
Danielle Minns +8 more
doaj +2 more sources
Cathelicidin Suppresses Colon Cancer Metastasis via a P2RX7-Dependent Mechanism
Molecular Therapy: Oncolytics, 2019 The antimicrobial peptide cathelicidin inhibits development of colitis-associated colon cancer. However, the role of cathelicidin in colon cancer metastasis remains unknown.
Jiani Wang +5 more
doaj +2 more sources
Cathelicidin suppresses colon cancer development by inhibition of cancer associated fibroblasts
Clinical and Experimental Gastroenterology, 2014 Michelle Cheng,1,* Samantha Ho,1,* Jun Hwan Yoo,1,2,* Deanna Hoang-Yen Tran,1,* Kyriaki Bakirtzi,1 Bowei Su,1 Diana Hoang-Ngoc Tran,1 Yuzu Kubota,1 Ryan Ichikawa,1 Hon Wai Koon1 1Center for Inflammatory Bowel Diseases, Division of Digestive Diseases ...
Cheng M +9 more
doaj +1 more source
Cathelicidin Insufficiency in Patients with Fatal Leptospirosis
PLOS Pathogens, 2016 Leptospirosis causes significant morbidity and mortality worldwide; however, the role of the host immune response in disease progression and high case fatality (>10-50%) is poorly understood. We conducted a multi-parameter investigation of patients with acute leptospirosis to identify mechanisms associated with case fatality.
Janet C. Lindow +18 more
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Cathelicidins: Immunomodulatory Antimicrobials [PDF]
Vaccines, 2018 Cathelicidins are host defense peptides with antimicrobial and immunomodulatory functions. These effector molecules of the innate immune system of many vertebrates are diverse in their amino acid sequence but share physicochemical characteristics like positive charge and amphipathicity.
Roel M. Van Harten +3 more
openaire +5 more sources
Cathelicidins and the Onset of Labour [PDF]
Scientific Reports, 2019 AbstractPreterm birth, defined as delivery before 37 weeks of gestation, is the leading cause of neonatal mortality and morbidity. Infection and inflammation are frequent antecedents of spontaneous preterm birth. Cathelicidin, an antimicrobial host defence peptide, is induced by infection and inflammation and although expressed in the reproductive ...
Sara R. van Boeckel +11 more
openaire +6 more sources
Dodecapeptide Cathelicidins of Cetartiodactyla: Structure, Mechanism of Antimicrobial Action, and Synergistic Interaction With Other Cathelicidins [PDF]
Frontiers in Microbiology, 2021 In this study, dodecapeptide cathelicidins were shown to be widespread antimicrobial peptides among the Cetruminantia clade. In particular, we investigated the dodecapeptide from the domestic goat Capra hircus, designated as ChDode and its unique ortholog from the sperm whale Physeter catodon (PcDode).
Ilia A. Bolosov +12 more
openaire +3 more sources