Results 21 to 30 of about 17,552 (216)

Antiviral Potential of Cathelicidins [PDF]

Future Microbiology, 2013
 The global burden of morbidity and mortality arising from viral infections is high; however, the development of effective therapeutics has been slow. As our understanding of innate immunity has expanded over recent years, knowledge of natural host defenses against viral infections has started to offer potential for novel therapeutic strategies.
Barlow, Peter G., Findlay, E.G., Currie, S.M., Davidson, D.J.   +3 more
openaire   +3 more sources

Dodecapeptide Cathelicidins of Cetartiodactyla: Structure, Mechanism of Antimicrobial Action, and Synergistic Interaction With Other Cathelicidins [PDF]

Frontiers in Microbiology, 2021
In this study, dodecapeptide cathelicidins were shown to be widespread antimicrobial peptides among the Cetruminantia clade. In particular, we investigated the dodecapeptide from the domestic goat Capra hircus, designated as ChDode and its unique ortholog from the sperm whale Physeter catodon (PcDode).
Ilia A. Bolosov, Pavel V. Panteleev, Pavel V. Panteleev, Sergei V. Sychev, Stanislav V. Sukhanov, Pavel A. Mironov, Pavel A. Mironov, Mikhail Yu. Myshkin, Zakhar O. Shenkarev, Zakhar O. Shenkarev, Tatiana V. Ovchinnikova, Tatiana V. Ovchinnikova, Tatiana V. Ovchinnikova   +12 more
openaire   +3 more sources

Vitamin D induction of the human antimicrobial Peptide cathelicidin in the urinary bladder. [PDF]

PLoS ONE, 2010
The urinary tract is frequently being exposed to potential pathogens and rapid defence mechanisms are therefore needed. Cathelicidin, a human antimicrobial peptide is expressed and secreted by bladder epithelial cells and protects the urinary tract from ...
Olof Hertting, Åsa Holm, Petra Lüthje, Hanna Brauner, Robert Dyrdak, Aino Fianu Jonasson, Peter Wiklund, Milan Chromek, Annelie Brauner   +8 more
doaj   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Entamoeba histolytica Induces Intestinal Cathelicidins but Is Resistant to Cathelicidin-Mediated Killing [PDF]

Infection and Immunity, 2012
ABSTRACTThe enteric protozoan parasiteEntamoeba histolyticais the cause of potentially fatal amebic colitis and liver abscesses.E. histolyticatrophozoites colonize the colon, where they induce inflammation, penetrate the mucosa, and disrupt the host immune system. The early establishment ofE.
Eduardo R, Cobo, Chen, He, Ken, Hirata, Grace, Hwang, UyenPhuong, Tran, Lars, Eckmann, Richard L, Gallo, Sharon L, Reed   +7 more
openaire   +2 more sources

Wound healing mechanism of antimicrobial peptide cathelicidin-DM

Frontiers in Bioengineering and Biotechnology, 2022
Background and Purpose: Chronic wound infections and the development of antibiotic resistance are serious clinical problems that affect millions of people worldwide.
Guixi Wang, Zhizhi Chen, Pan Tian, Qinqin Han, Jinyang Zhang, A-Mei Zhang, Yuzhu Song, Yuzhu Song   +7 more
doaj   +1 more source

Vitamin D, innate immunity and outcomes in community acquired pneumonia [PDF]

, 2011
We investigated the associations between vitamin D status, the antimicrobial peptides cathelicidin and beta defensin-2 and outcomes in community acquired pneumonia.
Karalus, Noel, LEONG LEOW, Cursons, Raymond T., RAY CURSONS, Hancox, Robert J., Leow, Leong, NOEL KARALUS, ROBERT J. HANCOX, TALIA SIMPSON, Leong, Talia   +9 more
core   +1 more source

Bronchoalveolar Lavage and Plasma Cathelicidin Response to 25-Hydroxy Vitamin D Supplementation: A Pilot Study. [PDF]

, 2021
INTRODUCTION: Cathelicidin is a vitamin D-regulated, antimicrobial peptide involved in the innate immune response of the airways. Reduced plasma cathelicidin concentrations are independently associated with worse pulmonary outcomes in current and former ...
Burkes, Robert M, Mock, Jason R, Hansel, Nadia N, Drummond, M Bradley, Liu, Mark C, Brown, Todd T, Sanders, Emily C, Wise, Robert A   +7 more
core   +1 more source

DataSheet1_Wound healing mechanism of antimicrobial peptide cathelicidin-DM.pdf

, 2022
Background and Purpose: Chronic wound infections and the development of antibiotic resistance are serious clinical problems that affect millions of people worldwide.
Zhizhi Chen (2209429), Qinqin Han (10271773), A-Mei Zhang (157343), Pan Tian (11878799), Guixi Wang (636912), Jinyang Zhang (2840411), Yuzhu Song (4379782)   +6 more
core   +1 more source

Cathelicidins from the bullfrog Rana catesbeiana provides novel template for peptide antibiotic design.

PLoS ONE, 2014
Cathelicidins, a class of gene-encoded effector molecules of vertebrate innate immunity, provide a first line of defense against microbial invasions. Although cathelicidins from mammals, birds, reptiles and fishes have been extensively studied, little is
Guiying Ling, Jiuxiang Gao, Shumin Zhang, Zeping Xie, Lin Wei, Haining Yu, Yipeng Wang   +6 more
doaj   +1 more source