Results 201 to 210 of about 72,817 (297)

Pemt Inhibition‐Mediated Vdac1 Oligomerization Regulates Mitochondrial Dysfunction, Apoptosis, and Inflammation in High‐Fat Diet‐Derived Liver Injury

Advanced Science, Volume 13, Issue 50, 7 September 2026.
ABSTRACT High‐fat diet (HFD)‐induced hepatic injury represents a pathology observed across vertebrates, yet the underlying mechanisms remain incompletely understood. Herein, the present study identifies phosphatidylethanolamine methyltransferase (Pemt), a key enzyme in phosphatidylcholine synthesis, as a critical regulator of mitochondrial homeostasis ...
Xianyong Bu, Xiufei Cao, Xin Yao, Baolin Li, Wencong Lai, Zengqi Zhao, Tingting Hao, Zhiwei Chen, Jianlong Du, Yueru Li, Kangsen Mai, Qinghui Ai   +11 more
wiley   +1 more source

INDUCTION OF MYOBLAST DIFFERENTIATION BY THE CYTOSOLIC SIALIDASE NEU2 OVEREXPRESSION

, 2003
F. Colombo, S. Marchesini, GIULIANI, Roberta, PRETI, Augusto, FANZANI, Alessandro, PRESTA, Marco   +5 more
core   +1 more source

Fumonisin-Induced Disruptions in Sphingolipid Metabolism: Implications for Steroid Hormone Biosynthesis and Hormone Modulation. [PDF]

Toxins (Basel)
Agyarko E, Ali O, Ikanya L, Zsarnovszky A, Kovács M, Szabó A.   +5 more
europepmc   +1 more source

Beyond PEG: Emerging Polymer Lipid Alternatives for Lipid Nanoparticle (LNP) Formulations

Advanced Science, Volume 13, Issue 50, 7 September 2026.
This review discusses recent advances in PEG‐alternative LNP designs, including non‐PEG polymers, zwitterionic lipids, and polypeptides. It evaluates how surface‐engineering chemistry influences LNP formation and biological behavior, and highlights current limitations and opportunities of PEG‐alternative LNPs.
Zihnil A. I. Mazrad, Yi Ju, Stephen J. Kent, Colin W. Pouton, Kristian Kempe   +4 more
wiley   +1 more source

Repurposed Aripiprazole-Loaded Hyaluronic Acid/Ceramide/Terpene Nanosponge as a Bioadhesive Topical Delivery System for Cutaneous <i>Candida albicans</i> Infection. [PDF]

Pharmaceuticals (Basel)
Albash R, Nair AB, Morsy MA, Venugopala KN, Shinu P, Hassan M, El-Sheikh AAK, Kassem AB.   +7 more
europepmc   +1 more source

ENT1 inhibition links oligodendrocyte lipid metabolism to connectivity in tauopathy

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Metabolic dysfunction, altered adenosine signaling, and white matter abnormalities are implicated in tauopathies, but their relationship to network disconnection remains unclear. Myelinating oligodendrocytes may represent a metabolically vulnerable hub linking these processes to circuit dysfunction.
Ching‐Pang Chang, Ching‐Wen Chang, Ching‐Wen Wu, Jian Jing Siew, David Blum, Lee‐Way Jin, You‐Yin Chen, Yijuang Chern   +7 more
wiley   +1 more source

Ceramide production at the plasma membrane

, 2009
M. Aureli, V.L. Chigorno, A.P. Masilamani, A.E.G. Prinetti, S. Sonnino, N. Loberto, G. Illuzzi   +6 more
core   +2 more sources

A novel prenylflavonoid with efficacy in cancer therapy by targeting ceramide-orchestrated signaling. [PDF]

Front Pharmacol
Du R, Zhang C, Lei H, Gao X, Xiang Q, Zhang Z, Dai Y, Li X, Zhang L, Chen G.   +9 more
europepmc   +1 more source

Perinatal lead (Pb) exposure and alterations to amyloid beta and metabolic profiles in the brain

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Developmental neurotoxicant exposures (e.g., lead [Pb]) are suspected contributors to dementia. Dementia is characterized by amyloid beta (Aβ) plaques and dysregulated metabolism. To better understand the relationship between environment and dementia risk, we assessed the impact of perinatal Pb exposure on dementia‐related ...
Rachel K. Morgan, Evelyn K. Matei, Junru Pan, Tomoko Ishikawa, Katelyn M. Polemi, Ingrid Bergin, Sean P. Ferris, Hao Wang, Dana C. Dolinoy, Kelly M. Bakulski, Justin A. Colacino   +10 more
wiley   +1 more source

Depression-induced systemic C16-ceramide deficiency promotes OSCC via attenuation of mitochondrial apoptosis. [PDF]

Cell Mol Life Sci
Pan Y, Guan J, Wang Y, Yang R, Lai K, Chen X, Xia J.   +6 more
europepmc   +1 more source