Results 191 to 200 of about 67,708 (303)

Influenza A Virus Infection Induces Preferential Increases in Long-Chain Ceramides. [PDF]

Viruses
McKenna S, Jung KI, Sumner B, Wolf JJ, Sumner LW, Hahm B.   +5 more
europepmc   +1 more source

HDL‐mimetic peptide treatment reverses APOE4‐induced transcriptomic and lipidomic alterations in the brain of humanized APOE mice

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION The apolipoprotein E4 (APOE4) allele is the strongest genetic risk factor for late‐onset Alzheimer's disease (AD). ApoE4 has reduced lipidation capacity and impaired lipid transport, disrupting neuronal maintenance. The high‐density lipoprotein (HDL)‐mimetic peptide 4F offers a potential therapeutic strategy.
Allison Chang, Minwoo Kim, Matthew Glittenberg, Wenhui Qu, Danni Li, Ling Li   +5 more
wiley   +1 more source

Reconstruction of Molecular Interaction Patterns from Endolysosomes in Ceramide-Depleted Cells. [PDF]

Nano Lett
Feng Y, Gärber F, Spedalieri C, Werner S, Pratsch C, Arenz C, Seifert S, Kneipp J.   +7 more
europepmc   +1 more source

Altered Sphingolipid Metabolism is Associated with Osimertinib Resistance in Nonsmall-Cell Lung Cancer. [PDF]

J Proteome Res
Babuta J, Gruevska A, Wickremesinghe C, Montoya A, Roumelioti G, Shliaha P, Balcells C, McKinney F, Bray C, Athersuch T, Martin M, Keun H, Hall Z.   +12 more
europepmc   +1 more source

Lifespan trajectories of serum sphingolipids in a clinically healthy Swiss population, towards precision medicine in cardiometabolic health assessment. [PDF]

Commun Med (Lond)
Carrard J, Gallart-Ayala H, Infanger D, Teav T, Wagner J, Knaier R, Hinrichs T, Hanssen H, Ivanisevic J, Schmidt-Trucksäss A.   +9 more
europepmc   +1 more source

Neurocognitive Aging Following Acute Illness: Pathobiology and a Framework for Developing Neurotherapeutic Agents

Brain and Behavior, Volume 16, Issue 6, June 2026.
In this review, we discuss the scientific basis for how neurocognitive aging occurs after critical illness, including sepsis, trauma, and burns, and the clinical need to develop therapies to reduce inflammation, protect the blood–brain barrier, remove senescent cells, and enhance neuroplasticity.
Errin Lawrence, Daniel Fulton, Poppy Brown, Subashini Suresh, Mark Morris, Paraskevi Goggolidou, Sree Chaithanya, Marcus Abbawy, Amelia Wild, Prashant Nasa, Niharika A. Duggal, Fang Gao‐Smith, Zubair Ahmed, Suresh Renukappa, Tonny Veenith   +14 more
wiley   +1 more source

Lipid metabolism as a marker for glioma aggressiveness. [PDF]

Biosci Rep
Ribas HT, Ribas GT, Paixão de Santana-Filho A, Jungles AG, Mesaros C, Guizelini D, Martinez GR, Trombetta-Lima M, Sassaki GL, Winnischofer SMB.   +9 more
europepmc   +1 more source

Quantifying Weight Loss Prior to Pancreatic Cancer Diagnosis: A Systematic Review and Meta‐Analysis

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Introduction Pancreatic cancer has a high mortality rate due to late diagnosis and presentation with non‐specific symptoms like weight loss. Quantifying weight loss more precisely could enhance its utility as a diagnostic marker. Methods In March 2025, we systematically searched PubMed, Embase, Web of Science, The Cochrane Library, and Scopus ...
Claire A. Price, Debbie Cooke, Freda Mold, Nadia A. S. Smith, Martyn Winn, Agnieszka Lemanska   +5 more
wiley   +1 more source

A Reproducible Ceramide Phenotype of Sepsis Across Aetiologies - A Monocenter Cohort Study. [PDF]

J Inflamm Res
Pavel V, Mester P, Höring M, Krautbauer S, Liebisch G, Schmid S, Müller M, Buechler C.   +7 more
europepmc   +1 more source

Metabolic Fingerprinting of Urine Reveals Metabolite Changes in Women With Breast Cancer

Cancer Medicine, Volume 15, Issue 6, June 2026.
This study uses metabolomics to compare urine, plasma and serum metabolite profiles across breast cancer, benign breast disease, symptomatic and healthy controls. Significant metabolic differences—especially in amino acids—were found between BC and other groups, with moderate correlations across biofluids, suggesting potential for non‐invasive BC ...
Nur Aimi Aliah Zainurin, Anuradha U. K. H. Bambarandhage, Michelle Moreno Escalona, Dimitra Ivanova, Tim Gate, Helen Tench, Manfred Beckman, Helen Phillips, Mandana Pennick, Luis A. J. Mur   +9 more
wiley   +1 more source