Results 191 to 200 of about 100,829 (298)

ASAH2 deficiency affects sphingolipid homeostasis and neuromotor control, causing a progressive neurological disorder. [PDF]

HGG Adv
Scala M, Sahu RK, Severino M, Traverso M, Iacomino M, Pedemonte M, Santorelli F, Tozza S, Zara F, Fiorillo C, Chung HL.   +10 more
europepmc   +1 more source

TEAD1 Enhances Exosome Secretion and Promotes Exosome‐Mediated Tissue Regeneration

Advanced Science, Volume 13, Issue 25, 4 May 2026.
TEAD1 functions as a crucial molecular switch regulating exosome secretion in various cell types. TEAD1 enhances exosome secretion by upregulating key proteins associated with exosome secretion, including RAB11, CD9, and SNAP23. This study reveals a novel role for TEAD1 in regulating exosome secretion and tissue regeneration, particularly in diabetic ...
Yan Pu, Yi Wan, Wenhao Shi, Bin Li, Haiyue Zhang, Jun Wu, Lingling Li, Wenjia Guo, Chen Ding, Wenjun Yang   +9 more
wiley   +1 more source

Correlation between ceramide and its metabolites and central precocious puberty: a cross-sectional study. [PDF]

BMC Pediatr
Guo D, Li Y, Ning X, Zhou Y, Wang C, Li X.   +5 more
europepmc   +1 more source

Immune Checkpoint Inhibitors and Immunomodulators for Cancer Immunotherapy: Insights Into Resistance and Therapeutic Strategies

Advanced Science, Volume 13, Issue 25, 4 May 2026.
The schematic diagram illustrates the roles of novel immune checkpoints, immunomodulatory factors, cell death and multimodal technologies in cancer immunotherapy. Abstract Cancer immunotherapy has redefined cancer treatment. However, the molecular and cellular basis of immune evasion and therapeutic resistance remains incompletely understood.
Fangquan Chen, Yang Yu, Xiutao Cai, Junhao Lin, Ruirui Liang, Rui Kang, Daolin Tang, Jiao Liu   +7 more
wiley   +1 more source

Noninvasive assessment of skin barrier function: evaluating ceramide-based moisturizer using confocal Raman spectroscopy. [PDF]

J Biomed Opt
Rajarahm P, Bi R, Attia AE, Zhang R, Thng STG, Ng SP, Yuan L, Olivo M.   +7 more
europepmc   +1 more source

Beyond Extracellular Vesicle (EV) Hype: Practical Solutions and Remaining Hurdles in EV Research, Manufacturing, and Clinical Translation

Advanced Science, Volume 13, Issue 26, 8 May 2026.
ABSTRACT Extracellular vesicles (EVs) are nanoscale mediators of intercellular communication with diverse molecular cargoes that reflect their cell of origin. Advances in isolation, detection, and single‐particle analytics have revealed increasing molecular and functional heterogeneity, while exposing limitations in how EV identity and activity are ...
David J. Lundy, Zoe L. Chau, Sheng‐You Chen, Nanami Fujisawa, John J. Hill, Barnett M. Hsu, Joanne K. Liu, Karol W. Mai, James J. Lai   +8 more
wiley   +1 more source

A Somatic Mutation in HIF-2α Affects Glucose and Lipid Metabolism via CD36 and Ceramide. [PDF]

FASEB J
Gao F, Feng X, Yao Q, Ji W, Zhang X, Pan Q, Zhu B, Yu J, Cao H, Zhang X.   +9 more
europepmc   +1 more source

GLP‐1 agonists and the gut microbiome: A bidirectional relationship

British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1309-1325, May 2026.
Abstract Glucagon‐like peptide‐1 (GLP‐1) receptor agonists have transformed the management of type 2 diabetes mellitus (T2DM) and obesity, yet their interactions with the gut microbiome remain an emerging frontier in pharmacological and metabolic research.
Srinivas Kamath, Nicole S. L. Chan, Paul Joyce   +2 more
wiley   +1 more source

Exploring Ceramide C16:0 as a Novel Biomarker and Therapeutic Target for Atherosclerosis. [PDF]

J Am Heart Assoc
Chen T, Xie L, Zhao Y, Shang Y, Pan Y, Wang W, Mao W.   +6 more
europepmc   +1 more source

Coronary artery disease risk and lipidomic profiles are similar in hyperlipidemias with family history and population-ascertained hyperlipidemias [PDF]

, 2019
et al,, Stitziel, Nathan O
core   +1 more source