Characterization of healthy vs. diabetic (73:67$$ 73:67 $$) random forest classification group and its Bayesian network learned through NOTEARS structure algorithm on multi‐modal data. Shown computed SHapley Additive exPlanation (SHAP) values for various features.
Ina Hanninger +8 more
wiley +1 more source
Genetic, Lipid, Fungal Microbiome and Neuroinflammatory Links Between Seborrheic Dermatitis and Parkinson's Disease: A Narrative Review. [PDF]
Kefala V +6 more
europepmc +1 more source
Caloric restriction improves glycemic control via the adiponectin-ceramide axis in non-obese men and women: the CALERIE™ 2 randomized controlled trial. [PDF]
Warmbrunn MV +8 more
europepmc +1 more source
ABSTRACT Aim The aim was to characterize the taxonomic and functional composition of the microbiome involved in primary endodontic infections and to evaluate their association with the periapical lesion size using shotgun metagenomic sequencing. Methodology Samples from primary root canal infections diagnosed with apical periodontitis were analysed ...
Virginia Pérez‐Carrasco +5 more
wiley +1 more source
Inhibition of acid sphingomyelinase links sphingolipid remodeling to necroptotic cell death. [PDF]
Pilapil LAE +2 more
europepmc +1 more source
PDE4 Inhibition in Dermatologic Disease: Impacts Beyond Inflammation
This graphical abstract demonstrates the comprehensive mechanism of PDE4 inhibition in skin physiology. By increasing intracellular cAMP and activating PKA, PDE4 inhibitors exert pleiotropic effects, including immune modulation, pigmentation regulation, barrier enhancement, sensory neuron modulation, and improved wound healing with reduced fibrosis ...
Keana Khodadad +2 more
wiley +1 more source
Malaria mosquito antimicrobial defence requires immunity and detoxification gene regulation by Lola
Malaria mosquito antimicrobial defence requires upregulation of lola. Attenuation of lola in the midgut of Anopheles albimanus mosquitoes inhibits the upregulation of immunity genes induced by challenge. Putative target genes of the Lola transcription factor were revealed by lola attenuation, including Cecropin‐C, Draper, PPAF2, Clip‐domain serine ...
Heidi Espadas‐Álvarez +1 more
wiley +1 more source
Extracellular vesicles from <i>Lactobacillus plantarum</i> alleviate DNFB-induced atopic dermatitis in mice by reconstructing the skin barrier and inhibiting inflammation. [PDF]
Shi Q +14 more
europepmc +1 more source
(A) Isolation and purification of LDNVs. (B) Establishment of the ALI model and LDNVs delivery. (C) Therapeutic mechanisms of LDNVs in treating ALI. This scheme figure was drawn by Figdraw, ID: IUIIO21222. ABSTRACT Acute lung injury (ALI) is a lethal respiratory disease.
Xi Lin +10 more
wiley +1 more source
Optimization of a Canine-Specific Ceramide Complex and Evaluation of Its Effects on In Vitro and In Vivo Canine Skin. [PDF]
Cho HY +8 more
europepmc +1 more source

