Results 151 to 160 of about 160,654 (303)
Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs–cAMP Signaling
Advanced Science, EarlyView.Our study identifies MINAR1 as a novel regulator of cortical interneuron excitability and seizure susceptibility. MINAR1 is preferentially expressed in SST+ interneurons. Genetic ablation of MINAR1 leads to seizure hypersensitivity, reduced SST+ neuron excitability, and impaired Gαs–cAMP signaling, disrupting the E/I balance.
Wei‐Tang Liu +20 more
wiley +1 more source
Ghrelin signaling in the cerebellar cortex enhances GABAergic transmission onto Purkinje cells. [PDF]
Sci Rep, 2023 Hirono M, Nakata M.
europepmc +1 more source
Advanced Science, EarlyView.Compared to untargeted therapy, the targeted nanocarrier, Angiopep‐2‐conjugated Lipid Nanoparticle (A‐LNP) loaded with TGN‐020 (TGN), selectively accumulated in stroke‐injured regions. It suppressed local aquaporin‐4 (AQP4) overexpression, thereby alleviating cerebral edema and hypoperfusion while preserving global glymphatic clearance.
Lei Jin +18 more
wiley +1 more source
Riboflavin attenuates tartrazine toxicity in the cerebellar cortex of adult albino rat. [PDF]
Sci Rep, 2022 Ismail OI, Rashed NA.
europepmc +1 more source
Advanced Science, EarlyView.SAGE is a unified framework for spatial domain identification in spatial transcriptomics that jointly models tissue architecture and gene programs. Topic‐driven gene selection (NMF plus classifier‐based scoring) highlights spatially informative genes, while dual‐view graph embedding fuses local expression and non‐local functional relations.
Yi He +5 more
wiley +1 more source
Effect of induced diabetes on morphometric indexes of the cerebellar cortex and gene expression in C57BL mice. [PDF]
Iran J Basic Med Sci, 2023 Sharifi S +4 more
europepmc +1 more source
Wearable Metamaterials with Embodied Intelligence for Programmable Control of Human Limbs Tremor
Advanced Intelligent Systems, EarlyView.Resulting from alternating muscle contractions, tremors can severely limit human ability to perform everyday tasks like walking or talking, due to their disruptive nature. Medication and surgery may not always effectively address tremor control. A wearable device embodying programmable smart metamaterials with adaptable intelligence to meet the demand ...
Braion Barbosa de Moura +2 more
wiley +1 more source
Subthalamic Nucleus Modulation of the Pontine Nuclei and Its Targeting of the Cerebellar Cortex. [PDF]
J Neurosci, 2022 Bhuvanasundaram R +2 more
europepmc +1 more source
Advanced Intelligent Systems, EarlyView.Natural fliers achieve remarkable aerial performance through diverse wing neuromechanical systems integrating actuation, sensing, and control. This study synthesizes neuromechanical architectures in insects and hummingbirds, identifying two key functional types‐Dual Neural‐Mechanical Oscillator and Neurally‐modulated Mechanical Oscillator‐ and ...
Suyash Agrawal +4 more
wiley +1 more source