Results 11 to 20 of about 161,013 (302)

Physical Activity as a Predictor of Cognitive Decline in an Elderly Essential Tremor Cohort: A Prospective, Longitudinal Study

Frontiers in Neurology, 2021
Background: Essential tremor (ET), one of the most common neurological diseases, is associated with cognitive impairment. Surprisingly, predictors of cognitive decline in ET remain largely unidentified, as longitudinal studies are rare.
Keith H. Radler, Silvia Chapman, Silvia Chapman, Maria Anna Zdrodowska, Hollie N. Dowd, Xinhua Liu, Edward D. Huey, Edward D. Huey, Edward D. Huey, Stephanie Cosentino, Stephanie Cosentino, Elan D. Louis   +11 more
doaj   +1 more source

Cerebellar development and disease [PDF]

Current Opinion in Neurobiology, 2008
The molecular control of cell-type specification within the developing cerebellum as well as the genetic causes of the most common human developmental cerebellar disorders have long remained mysterious. Recent genetic lineage and loss-of-function data from mice have revealed unique and nonoverlapping anatomical origins for GABAergic neurons from ...
Kathleen J, Millen, Joseph G, Gleeson
openaire   +2 more sources

Cerebellar Integrity in the Amyotrophic Lateral Sclerosis - Frontotemporal Dementia Continuum [PDF]

, 2014
Amyotrophic lateral sclerosis (ALS) and behavioural variant frontotemporal dementia (bvFTD) are multisystem neurodegenerative disorders that manifest overlapping cognitive, neuropsychiatric and motor features.
A Giordano, AE Renton, BR Brooks, C Dobson-Stone, C Habas, C Lomen-Hoerth, C Mottolese, C Wedderburn, Carol Dobson-Stone, CJ Mahoney, CJ O'Halloran, CJ Stoodley, CJ Stoodley, CJ Stoodley, CJ Stoodley, CM Clark, D Seok Yi, DJ Irwin, DM Mezzapesa, E Mioshi, E Mioshi, E Mioshi, E Sbardella, EC Lauterbach, Emma Devenney, F Begeti, FA Middleton, FM Krienen, Glenda M. Halliday, GM Ringholz, H Baillieux, H Yoshida, HJ Rosen, HJ Rosen, J Kassubek, J Phukan, J Senda, Jan Kassubek, JD Schmahmann, JD Schmahmann, JH Balsters, JL Chang, JL Whitwell, JL Whitwell, JL Whitwell, JLR Andersson, JM Cedarbaum, John B. Kwok, John R. Hodges, JR Burrell, JS Snowden, JX O'Reilly, K Rascovsky, KA Josephs, L Thivard, LT Takada, M Irish, M Neumann, Matthew C. Kiernan, MC Kiernan, Michael Hornberger, MJ Strong, MP Alexander, MR Turner, O Hardiman, P Lillo, P Lillo, P McColgan, R Villanueva, Rachel H. Tan, RM Kelly, SM Smith, SM Smith, T Kanda, TE Nichols, TH Bak, V Garibotto, WW Seeley, Y Zhang, Z Chen, Z Terpening   +80 more
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Phenotypic and genetic aspects of hereditary ataxia in dogs

Journal of Veterinary Internal Medicine, 2023
Hereditary ataxias are a large group of neurodegenerative diseases that have cerebellar or spinocerebellar dysfunction as core feature, occurring as an isolated sign or as part of a syndrome.
Kimberley Stee, Mario Van Poucke, Mark Lowrie, Luc Van Ham, Luc Peelman, Natasha Olby, Sofie F.M. Bhatti   +6 more
doaj   +1 more source

Cerebellar Syndromes: A Medical Student Guide

International Journal of Medical Students, 2013
The cerebellum is central to normal motor function and co-ordination, and can be frequently affected in a number of common disease processes. However, medical student teaching relating to cerebellar anatomy and pathology is lacking, leaving many ...
Claudia K. Sellers, Suvankar Pal
doaj   +1 more source

Novel homozygous GBA2 mutation in a patient with complicated spastic paraplegia [PDF]

, 2018
Hereditary spastic paraplegias (HSPs) are a heterogeneous group of neurological disorders characterized primarily by a pyramidal syndrome with lower limb spasticity, which can manifest as pure HSP or associated with a number of neurological or non ...
Bertini, Enrico, Coarelli, Giulia, Ferraldeschi, Michela, Fornasiero, Arianna, Frontali, Marina, Nicita, Francesco, Ristori, Giovanni, Romano, Silvia, Salvetti, Marco, Spadaro, Maria, Travaglini, Lorena   +10 more
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Cerebellar connectome alterations and associated genetic signatures in multiple sclerosis and neuromyelitis optica spectrum disorder

Journal of Translational Medicine, 2023
Background The cerebellum plays key roles in the pathology of multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD), but the way in which these conditions affect how the cerebellum communicates with the rest of the brain (its ...
Yuping Yang, Junle Li, Ting Li, Zhen Li, Zhizheng Zhuo, Xuemei Han, Yunyun Duan, Guanmei Cao, Fenglian Zheng, Decai Tian, Xinli Wang, Xinghu Zhang, Kuncheng Li, Fuqing Zhou, Muhua Huang, Yuxin Li, Haiqing Li, Yongmei Li, Chun Zeng, Ningnannan Zhang, Jie Sun, Chunshui Yu, Fudong Shi, Umer Asgher, Nils Muhlert, Yaou Liu, Jinhui Wang   +26 more
doaj   +1 more source

ATXN2-CAG42 sequesters PABPC1 into insolubility and induces FBXW8 in cerebellum of old ataxic knock-in mice [PDF]

, 2012
Spinocerebellar Ataxia Type 2 (SCA2) is caused by expansion of a polyglutamine encoding triplet repeat in the human ATXN2 gene beyond (CAG)31. This is thought to mediate toxic gain-of-function by protein aggregation and to affect RNA processing ...
Auburger, Georg, Azizov, Mekhman, Damrath, Ewa, Gispert, Suzana, Heck, Melanie V., Nowock, Joachim, Rüb, Udo, Seifried, Carola, Walter, Michael   +8 more
core   +3 more sources

Investigation of Known Genetic Mutations of Arabian Horses in Egyptian Arabian Foals with Juvenile Idiopathic Epilepsy. [PDF]

, 2017
BackgroundThe carrier status of lavender foal syndrome (LFS), cerebellar abiotrophy (CA), severe combined immunodeficiency (SCID), and occipitoatlantoaxial malformation (OAAM1) in foals with juvenile idiopathic epilepsy (JIE) is unknown.Hypothesis ...
Aleman, M, Finno, CJ, Penedo, MCT, Weich, K   +3 more
core   +1 more source

Ataxias cerebelares hereditárias: do martelo ao gen Hereditary cerebellar ataxias from neurological hammer to genetics

Arquivos de Neuro-Psiquiatria, 1997
As heredoataxias constituem grupo complexo de doenças neurodegenerativas hereditárias, para o qual várias formas de classificação clínica e patológica foram propostas com sucesso variável.
Walter Oleschko Arruda, Hélio A. Ghizoni Teive   +1 more
doaj   +1 more source