Results 161 to 170 of about 182,686 (297)

Ischaemic stroke and 5‐fluorouracil or capecitabine: A systematic review and meta‐analysis of harms and a retrospective study of the WHO pharmacovigilance database

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Aim Fluoropyrimidines, including 5‐fluorouracil (5‐FU) and capecitabine, are cornerstone antineoplastic agents for cancer. Case reports suggest that these drugs may be associated with an under‐recognised risk of ischaemic stroke or transient ischaemic attack (TIA).
Sophie Nguyen   +12 more
wiley   +1 more source

Distinct Clinicogenomic Contexts of BRAF‐Altered Gliomas and Glioneuronal Tumors: A Nationwide Real‐World Study

open access: yesCancer Science, EarlyView.
Nationwide real‐world profiling revealed distinct clinicogenomic contexts across major BRAF alteration classes in gliomas and glioneuronal tumors. KIAA1549::BRAF fusion was associated with younger age and predominantly low‐grade tumors, whereas BRAF amplification‐only tumors were predominantly high‐grade and showed frequent MET amplification.
Seiji Yamada   +7 more
wiley   +1 more source

Diagnostic Yield of Brain MRI in Pediatric Short Stature: Hypothalamic–Pituitary Lesions and Incidental Findings in Real‐World Practice

open access: yesClinical Endocrinology, EarlyView.
ABSTRACT Background Brain MRI is widely performed in children with short stature or suspected growth hormone deficiency(GHD) to exclude hypothalamic–pituitary (HP) pathology, yet its diagnostic yield in routine practice is uncertain. We aimed to evaluate the prevalence, clinical significance, and distribution of HP and extrahypothalamic abnormalities ...
Mustafa Zubeidat   +2 more
wiley   +1 more source

Disseminated Xanthogranuloma Harboring a GAB2::BRAF Fusion and MITF Pathogenic Variant Successfully Treated With Cobimetinib: A Rare Case Report

open access: yesJournal of Cutaneous Pathology, EarlyView.
ABSTRACT Several activating mutations and gene fusions involving the mitogen‐activated protein kinase (MAPK) pathway have appeared in the literature regarding histiocytic neoplasms. We identified a GAB2::BRAF fusion in a cutaneous lesion of a 36‐year‐old male who developed central diabetes insipidus and reddish‐pink grouped papules on the bilateral ...
Pauline C. Xu   +3 more
wiley   +1 more source

Breast Cancer with Subacute Progressive Neurological Symptoms due to Anti-Yo Antibody-Associated Paraneoplastic Neurological Syndrome: A Case Report. [PDF]

open access: yesSurg Case Rep
Tasaki M   +9 more
europepmc   +1 more source

Inborn errors of immunity in children with neuroinflammation

open access: yesDevelopmental Medicine &Child Neurology, EarlyView.
Abstract Inborn errors of immunity (IEIs), an expanding group of monogenic disorders with diverse clinical manifestations, are increasingly recognized to include neuroinflammatory disease. Examples of diseases included under this umbrella are Aicardi–Goutières syndrome, deficiency of adenosine deaminase 2, familial haemophagocytic lymphohistiocytosis ...
Eppie M Yiu   +5 more
wiley   +1 more source

Home - About - Disclaimer - Privacy