Results 231 to 240 of about 31,605 (321)

Imaging features of high-grade astrocytoma with piloid features: A single center case series. [PDF]

Neuroradiol J
Al Qudah H, D Hamilton J, A Gubbiotti M, Msherghi A, Salim HA, Alizada S, Liu HL, Kumar VA, Wintermark M, Eldaya RW.   +9 more
europepmc   +1 more source

Evaluation of ASC as a therapeutic target for Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract Neuroinflammation is increasingly recognized as a central contributor to the pathogenesis and progression of Alzheimer's disease (AD). The apoptosis‐associated speck‐like protein containing a CARD (ASC), encoded by the PYCARD gene, plays a critical role in the formation of multiple inflammasomes, including NLRP3, a key mediator of inflammation
W. Brent Clayton, Joshua A. Kulas, Jiahui Liu, Nidhi Walia, Claudia Rangel‐Barajas, Travis Johnson, Jie Zhang, Kun Huang, Andrew D. Mesecar, Jeffrey L. Dage, Bruce T. Lamb, Alan D. Palkowitz, Timothy I. Richardson   +12 more
wiley   +1 more source

Case report: Von Hippel-Lindau syndrome with multisystem involvement: a therapeutic dilemma. [PDF]

Front Oncol
He S, Wang C, Yang J, Shen J, Zeng X, Zheng J, Wang Y.   +6 more
europepmc   +1 more source

New Quinoline Kinase Inhibitors With Good Selectivity for NAK Kinases and Anti‐Tumor Activity Against Ewing Sarcoma

Archiv der Pharmazie, Volume 359, Issue 1, January 2026.
Focusing on the discovery of new therapeutics for childhood cancer, novel quinoline derivatives were synthesized and demonstrated activity against Ewing sarcoma. A target search was performed against a panel of kinases, and the compounds showed selectivity for the NAK family, mainly GAK, which was confirmed by enzyme kinetic assays.
Caroline de Bem Gentz, Thais Helena Maciel Fernandes, Marcela Silva Lopes, Lewis Elson, Andreas Krämer, Lucas Rodrigo de Souza, Isadora Serraglio Fortes, Geórgia Silva Pinto, Martha Cestari Silva Martins, Henrique Barros de Lima, André da Silva Santiago, Lauro José Gregianin, Katlin Brauer Massirer, Mário Henrique Bengtson, Rafael Roesler, Stefan Knapp, Stefan A. Laufer, Saulo Fernandes de Andrade   +17 more
wiley   +1 more source

The meningeal-cerebellar axis: a new perspective on cerebellar development. [PDF]

Cell Mol Life Sci
Al-Sayyar A, Salvon L, Haidar N, Schult P, Kassem O, Rua R, Romano A.   +6 more
europepmc   +1 more source

The Clinical Characteristics and Treatment of Patients With Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy (GFAP‐A): A Retrospective Study of 29 Patients

Brain and Behavior, Volume 16, Issue 1, January 2026.
A retrospective analysis of clinical features, treatment, and outcome of 29 patients with autoimmune glial fibrillary acidic protein astrocytopathy (GFAP‐A). Cerebrospinal fluid (CSF) pressure, CSF nucleated cell count, CSF protein levels, CSF chloride, serum thyroid dysfunction, and abnormal blood cytokine levels correlated with disease severity but ...
Xuewei Yang, Lanling Jin, Chanhong Shi, Hongwei Yue, Hongfei He, Wenli Zhu, Ruili Wei   +6 more
wiley   +1 more source

Revisiting the role of histopathology in acute intracerebral hemorrhage: Detecting missed secondary lesions beyond neuroimaging. [PDF]

Surg Neurol Int
Sofue T, Chatani M, Miyoshi N, Takahashi K, Yamamoto S, Kuga Y, Ohnishi H, Ohnishi H.   +7 more
europepmc   +1 more source

Salivary Gland Uptake on 18F‐Florbetaben PET Did Not Demonstrate Additional Diagnostic Value for Alzheimer's Disease

Brain and Behavior, Volume 16, Issue 1, January 2026.
Salivary gland uptake on 18F‐florbetaben PET was not associated with cortical amyloid burden in patients across the cognitive spectrum. No significant differences in salivary gland amyloid‐PET uptake were observed according to dementia severity or clinical diagnosis.
Hyun Woo Kwon, Saim Jung, Cheolmin Shin, Jong Hun Kim, Moon Ho Park   +4 more
wiley   +1 more source

Neurological, Neuropsychological, and Social Outcomes in Pediatric Patients Diagnosed With Cerebellar Mutism Syndrome: A Systematic Review. [PDF]

Pediatr Blood Cancer
Hughes MH, Paturzo JGR, Fernandez CM, Garg KS, Rajan J, Rahematpura S, DiBello JR, Shaikh UR, Wrigley JE, Philips NS, Raches D, Hudson MM, Sarvode S.   +12 more
europepmc   +1 more source