Sporadic solid hemangioblastoma of the cerebellar vermis: A case report. [PDF]
Okunlola AI +5 more
europepmc +1 more source
Advances in Multidimensional Molecular Mechanisms of Epilepsy and Precision Therapy Strategies
Epilepsy arises from a multidimensional network imbalance, integrating genetic, inflammatory, and metabolic disruptions. This complexity drives neuronal hyperexcitability and underpins therapeutic challenges. Our review highlights how emerging precision strategies, from targeted molecular therapies to neuromodulation, offer a transformative path toward
Yimin Han +7 more
wiley +1 more source
Paraneoplastic Neurological Syndromes in Ovarian Cancer: Case Report and Narrative Review for Diagnostic and Clinical Implications. [PDF]
Restaino S +17 more
europepmc +1 more source
Frontal and temporal hypoperfusion is observed in frontotemporal dementia, showing spatial concordance with gray matter atrophy and hypometabolism of glucose. Frontal hypoperfusion correlates significantly with peripheral vascular biomarkers and clinical phenotypes.
Jiahui Hou +7 more
wiley +1 more source
Case Report: A case of anti-mGluR1 antibody-associated encephalitis treated with efgartigimod combined with rituximab. [PDF]
Liu J, Zhu W, Gao L, Zhao C.
europepmc +1 more source
Circular RNA SMAD4 coordinates with m6A‐dependent IGF2BP2 to promote gallbladder cancer development
• circSMAD4 is upregulated in GBC and is associated with poor survival. • IGF2BP2 promotes circSMAD4 biogenesis through m6A‐dependent recognition mediated by its KH3‐KH4 domains. • circSMAD4 and IGF2BP2 reciprocally stabilize each other, forming a positive feedback loop that activates JAK2/STAT3 signalling and EMT.
Yiming Li +15 more
wiley +1 more source
Hemorrhagic Brain Tumor As the Initial Presentation of Metastatic Testicular Yolk Sac Tumor: A Case Report and Review of the Literature. [PDF]
Hafiz BE +4 more
europepmc +1 more source
ABSTRACT Epilepsy is the most disabling neurological disease that affects all economic classes, age groups, regions, and races. Although many antiseizure drugs are approved for epilepsy treatment, they fail to work in about 30%–40% of patients. Thus, there is a great need to identify better pharmacological agents to treat epilepsy.
Janakiraman Pillai Udaiyappan +3 more
wiley +1 more source
Primary Intracranial Cholesteatoma Presenting as a Cerebellar Mass Without Otologic Symptoms. [PDF]
Blanco Espinosa E +5 more
europepmc +1 more source
Pathogenic variants alter hepaCAM protein distribution. Astrocyte‐specific hepaCAM TurboID reveals KCNQ2 as a new interaction partner. Pathogenic variants alter hepaCAM association with key transmembrane proteins. ABSTRACT Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a rare leukodystrophy characterized by early‐onset macrocephaly,
Robert W. Lewis +10 more
wiley +1 more source

