Results 111 to 120 of about 578,102 (305)

Remimazolam Ameliorates Autistic‐Like Behaviors via Suppression of Ferroptosis in VTA Dopaminergic Neurons in a Mouse Model of ASD

Advanced Science, EarlyView.
The ultra‐short‐acting sedative remimazolam has a sustained therapeutic effect on the core symptoms of VPA‐exposed mice. Remimazolam, a GABA agonist, exerts its therapeutic effects by protecting dopamine neurons in the VTA of VPA‐exposed mice. Meanwhile, ferroptosis is the critical mechanism by which remimazolam protects VTA dopaminergic neurons and ...
Yuxin Zhang, Jianwei Lin, Chaoyang Tong, Xin Fu, Mengqin Shan, Yue Huang, Kan Zhang, Jijian Zheng   +7 more
wiley   +1 more source

Progressive ataxia and palatal tremor (PAPT) with hypertrophic olivary degeneration (HOD): A case report

Radiology Case Reports
Palatal tremor has been subdivided into essential (EPT) and symptomatic palatal tremor (SPT). Progressive ataxia and palatal tremor syndrome (PAPT) is a subgroup of symptomatic palatal tremor (SPT).
Salma Marrakchi, Khadija Laasri, Rim Moufakkir, Yousra Guelzim, Ihssan Hadj hsain, Zakia El yousfi, Jamal El Fenni, Hassan En-nouali   +7 more
doaj   +1 more source

Delayed Complex Spike Response Evoked by Conditioned Stimulus Encodes Movement Onset Time and Is Determined by Intrinsic Inferior Olive Properties

Frontiers in Systems Neuroscience, 2019
Recent studies demonstrate that after classical conditioning the conditioned stimulus (CS) triggers a delayed complex spike. This new finding revolutionizes our view on the role of complex spike activity.
Yasmin Yarden-Rabinowitz, Yasmin Yarden-Rabinowitz, Yosef Yarom, Yosef Yarom   +3 more
doaj   +1 more source

ATXN2-CAG42 sequesters PABPC1 into insolubility and induces FBXW8 in cerebellum of old ataxic knock-in mice [PDF]

, 2012
Spinocerebellar Ataxia Type 2 (SCA2) is caused by expansion of a polyglutamine encoding triplet repeat in the human ATXN2 gene beyond (CAG)31. This is thought to mediate toxic gain-of-function by protein aggregation and to affect RNA processing ...
Auburger, Georg, Azizov, Mekhman, Damrath, Ewa, Gispert, Suzana, Heck, Melanie V., Nowock, Joachim, Rüb, Udo, Seifried, Carola, Walter, Michael   +8 more
core   +3 more sources

Taurocholic Acid Is Associated With Disturbed Functional Connectivity in the Hippocampus of Patients With Depression

Advanced Science, EarlyView.
This study identifies elevated taurocholic acid (TCA) in Major Depressive Disorder patients. Gut microbiome‐associated TCA impairs hippocampal neurogenesis, triggers microglia activation, and elicits depression‐like behavior in mice via the S1PR2. In patients, functional neuroimaging reveals that serum TCA levels correlate with altered functional ...
Xiaoying Cai, Taipeng Sun, Mengzhen Feng, Gang Chen, Junchi Zhou, Hong Zhuang, Dan Wang, Ying Chen, Zhen Cheng, Zhi Xu, Xiao Zheng, Xueli Zhang, Yonggui Yuan   +12 more
wiley   +1 more source

Magnetic resonance imaging pattern recognition of metabolic and neurodegenerative encephalopathies in dogs and cats

Frontiers in Veterinary Science
Metabolic/neurodegenerative encephalopathies encompass a wide list of conditions that share similar clinical and magnetic resonance imaging (MRI) characteristics, challenging the diagnostic process and resulting in numerous tests performed in order to ...
María Miguel-Garcés, Rita Gonçalves, Rodrigo Quintana, Patricia Álvarez, Katrin M. Beckmann, Emili Alcoverro, Melania Moioli, Edward J. Ives, Megan Madden, Sergio A. Gomes, Evelyn Galban, Tim Bentley, Koen M. Santifort, Koen M. Santifort, An Vanhaesebrouck, Chiara Briola, Chiara Briola, Patricia Montoliu, Patricia Montoliu, Unai Ibaseta, Inés Carrera   +20 more
doaj   +1 more source

A potential role for the cerebellar nuclei in absence seizures [PDF]

, 2013
© 2013 Alva et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
Adams, R.G., Alva, Parimala, Davey, N., De Zeeuw, Chris I., Hoebeek, Freek E., Kroos, Lieke, Maex, Reinoud, Steuber, Volker   +7 more
core   +1 more source

Nurr1 Orchestrates Claustrum Development and Functionality

Advanced Science, EarlyView.
Nurr1 (Nr4a2) is the master transcription factor to control claustrum morphogenesis and cell fate decision postmitotically by inhibiting intracellular G‐protein signaling. Nurr1 deficiency alters the transcriptomic profiles of subcortical claustral neurons into neocortical insular neurons, resulting in defected claustrum development, impaired axonal ...
Kuo Yan, Andrew G. Newman, Pauline Lange, Susanne Müller, Marco Foddis, Stefan Paul Koch, Philipp Böhm‐Sturm, Maron Mantwill, Carsten Finke, Penghui Deng, Melissa Long, Dietmar Schmitz, Victor Tarabykin   +12 more
wiley   +1 more source

A candidate projective neuron type of the cerebellar cortex: the synarmotic neuron

European Journal of Histochemistry
Previous studies on the granular layer of the cerebellar cortex have revealed a wide distribution of different subpopulations of less-known large neuron types, called “non-traditional large neurons”, which are distributed in three different zones of the
Paolo Flace, Diana Galletta, Antonella Bizzoca, Gianfranco Gennarini, Paolo Livrea   +4 more
doaj   +1 more source

Neurones glycinergiques et transmission inhibitrice dans les noyaux cérébelleux [PDF]

, 2014
The cerebellum is composed of a three-layered cortex and of nuclei and is responsible for the learned fine control of posture and movements.
Husson, Zoé
core   +2 more sources