Results 131 to 140 of about 578,102 (305)
ERM Inhibition Confers Ferroptosis Resistance through ROS‐Induced NRF2 Signaling
Advanced Science, EarlyView.ERM inhibition disrupts ERM‐actin interactions, elevating ROS and triggering KEAP1 degradation, which stabilizes and activates NRF2. Nuclear NRF2 induces cytoprotective genes, notably HMOX1, enhancing redox buffering and suppressing lipid peroxidation to resist erastin‐induced ferroptosis.
Menghao Qiao +19 more
wiley +1 more source
Spike burst-pause dynamics of Purkinje cells regulate sensorimotor adaptation.
PLoS Computational Biology, 2019 Cerebellar Purkinje cells mediate accurate eye movement coordination. However, it remains unclear how oculomotor adaptation depends on the interplay between the characteristic Purkinje cell response patterns, namely tonic, bursting, and spike pauses ...
Niceto R Luque +4 more
doaj +1 more source
Isoperimetric Partitioning: A New Algorithm for Graph Partitioning [PDF]
, 2003 Temporal structure is skilled, fluent action exists at several nested levels. At the largest scale considered here, short sequences of actions that are planned collectively in prefronatal cortex appear to be queued for performance by a cyclic competitive
Grady, Leo, Schwartz, Eric
core +1 more source
Light Therapy Alleviates Addiction‐Related Symptoms and Reshapes Habenula and Midbrain Pathways
Advanced Science, EarlyView.This study investigates light therapy for treating Internet Gaming Disorder (IGD). Functional MRI (fMRI) data reveal that light therapy enhances brain connectivity, particularly between the habenula and the medial orbitofrontal cortex (mOFC). These changes are associated with reduced withdrawal symptoms and addiction severity, highlighting the ...
Jinhui Li +10 more
wiley +1 more source
Aberrant Splicing Signatures Underpin Oligodendrocyte Damage in ALS and Neuron Loss in FTD
Advanced Science, EarlyView.Integrating bulk and single‐nucleus RNA‐seq from ALS and FTD patients, we revealed distinct cellular dysfunctions, with severe oligodendrocyte damage in ALS and pronounced neuron loss in FTD. We identified cell‐type‐specific aberrant splicing events as potential biomarkers with robust classification performance, some of which produce de novo peptides ...
Chen Du +6 more
wiley +1 more source
NeurotherapeuticsDystonia is the third most common movement disorder and an incapacitating co-morbidity in a variety of neurologic conditions. Dystonia can be caused by genetic, degenerative, idiopathic, and acquired etiologies, which are hypothesized to converge on a ...
Megan X. Nguyen +4 more
doaj +1 more source
Motor Deficits after Cerebellar Tumor Resection
Pediatric Neurology Briefs, 2005 Cognitive and motor performance after resection of a cerebellar tumor was studied in 22 patients (age range 10-28 years) at University of Minnesota, MN.
J Gordon Millichap
doaj +1 more source
Advanced Science, EarlyView.This schematic integrates the eight statistically significant causal relationships identified between 1,366 brain imaging‐derived phenotypes (IDPs) and 18 autoimmune inflammatory diseases (AIDs). Arrows indicate the direction of causality inferred from bidirectional two‐sample MR analyses.
Jinbin Chen +8 more
wiley +1 more source
Neuronal Migration During Development of the Cerebellum
Frontiers in Cellular Neuroscience, 2018 Neuronal migration is a fundamental process in central nervous system (CNS) development. The assembly of functioning neuronal circuits relies on neuronal migration occurring in the appropriate spatio-temporal pattern.
Maryam Rahimi-Balaei +5 more
doaj +1 more source
On the Cerebellar Nuclei of Birds
Archivum histologicum japonicum, 1957 1. The cerebellar nuclei of birds comprise the nuclei medialis, interpositus and lateralis which form single masses respectively and never divide into subnuclei.2. These three nuclei show conspicuous mutual confluence.3. A frank confluence is also observed between the cerebellar nuclei and the nucleus vestibularis.
Shigeaki YAMAMOTO +2 more
openaire +2 more sources