Results 131 to 140 of about 354,424 (374)

CNS Mitochondria‐Derived Vesicle in Blood: Potential Biomarkers for Brain Mitochondria Dysfunction

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial dysfunction is a hallmark of neurodegenerative diseases like Alzheimer's (AD) and Parkinson's (PD). Our goal was to develop practical, noninvasive methods to assess mitochondrial status through the detection of mitochondria‐derived vesicles (MDVs).
Qi Liu, Wentao Chen, Yahong Wu, Zhen Guo, Jun Chen, Chen Tian, Pan Wang, Shaopeng Zeng, Bin Xu, Jing Duan, Shilong Han, Xiao Xiong, Jing Zhang   +12 more
wiley   +1 more source

Developmental Anatomy of Cerebellum of Long-Tailed Macaque (Macaca fascicularis) at the First Trimester of Gestation

Jurnal Sain Veteriner, 2014
Long tailed macaque was one of animal models in biomedical research because it has  many similarities with humans, both anatomical and physiological properties.
Tri Wahyu Pangestiningsih, Irene Linda Megawati Saputra, Agnya Sinung Suminar   +2 more
doaj   +1 more source

Comprehensive study on influence of low dose chronic consumption of silver nanoparticles on cognitive functions and identification of the effect reasons [PDF]

arXiv, 2018
The influence of the daily prolonged administration of silver nanoparticles on cognitive functions of model mammals was studied. The accumulation of silver in whole brain, hippocampus, cerebellum, cortex and residual part of mice brain was investigated by highly precise and representative Neutron Activation Analysis and the histological studies were ...
arxiv  

Histone Deacetylase 6 Brain PET in Amyotrophic Lateral Sclerosis‐Frontotemporal Spectrum Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective [18F]EKZ‐001 is a positron emission tomography (PET) tracer targeting histone deacetylase 6 (HDAC6), an enzyme responsible for intracellular transport and clearance of misfolded proteins. HDAC6 modulation is a promising treatment strategy in neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS).
Greet Vanderlinden, Charles Carron, Donatienne Van Weehaeghe, Joke De Vocht, Fouke Ombelet, Pegah Masrori, Caro De Weerdt, Rebecca E. James, Lauren T. Evans, Frederick A. Schroeder, Jacob M. Hooker, Michel Koole, Janice E. Kranz, Tonya M. Gilbert, Philip Van Damme, Koen Van Laere   +15 more
wiley   +1 more source

Artificial cerebellum on FPGA: realistic real-time cerebellar spiking neural network model capable of real-world adaptive motor control

Frontiers in Neuroscience
The cerebellum plays a central role in motor control and learning. Its neuronal network architecture, firing characteristics of component neurons, and learning rules at their synapses have been well understood in terms of anatomy and physiology.
Yusuke Shinji, Hirotsugu Okuno, Yutaka Hirata, Yutaka Hirata, Yutaka Hirata   +4 more
doaj   +1 more source

The Cerebellum: New Computational Model that Reveals its Primary Function to Calculate Multibody Dynamics Conform to Lagrange-Euler Formulation [PDF]

IJCSI International Journal of Computer Science Issues, Vol. 10, Issue 5, No 2, September 2013, 2014
Cerebellum is part of the brain that occupies only 10% of the brain volume, but it contains about 80% of total number of brain neurons. New cerebellar function model is developed that sets cerebellar circuits in context of multibody dynamics model computations, as important step in controlling balance and movement coordination, functions performed by ...
arxiv  

Vision-Based Control for Robots by a Fully Spiking Neural System Relying on Cerebellar Predictive Learning [PDF]

arXiv, 2020
The cerebellum plays a distinctive role within our motor control system to achieve fine and coordinated motions. While cerebellar lesions do not lead to a complete loss of motor functions, both action and perception are severally impacted. Hence, it is assumed that the cerebellum uses an internal forward model to provide anticipatory signals by ...
arxiv  

Mechanisms of cognitive-behavioral therapy for obsessive-compulsive disorder involve robust and extensive increases in brain network connectivity. [PDF]

, 2017
Cognitive-behavioral therapy (CBT) is effective for obsessive compulsive disorder (OCD); however, little is understood about its mechanisms related to brain network connectivity.
Cheng, G, Feusner, JD, Moody, TD, Morfini, F, O'Neill, J, Reggente, N, Sheen, C, Tadayonnejad, R   +7 more
core   +1 more source

FUNCTION OF THE CEREBELLUM [PDF]

The Journal of Nervous and Mental Disease, 1883
n ...
openaire   +3 more sources

Longitudinal Relationship Between Pain and Depression in People With Inflammatory Arthritis: A Narrative Review

Arthritis Care &Research, EarlyView.
As many patients with inflammatory arthritis (IA) have chronic pain, understanding how to best assess and manage pain in IA is a priority. Comorbid depression is prevalent in adults with IA, affecting 15% to 39% of people. Although pain and depression are thought to be associated in IA, this concept is largely based on cross‐sectional data.
Natasha Cox, Saeed Farooq, Helen Twohig, Ian C. Scott   +3 more
wiley   +1 more source