Results 181 to 190 of about 354,424 (374)

3‐[3‐(Phenalkylamino)cyclohexyl]phenols: Synthesis, biological activity, and in silico investigation of a naltrexone‐derived novel class of MOR‐antagonists

Archiv der Pharmazie, Volume 356, Issue 1, January 2023., 2023
Based on a simplified version of the morphinan scaffold, 3‐[3‐(phenalkylamino)cyclohexyl]phenol analogues were designed, synthesized and evaluated for their µ‐opioid receptor (MOR) antagonist activity in vitro and in silico. Docking studies indicate a peculiar combination of C‐1 stereochemistry and N‐substitutions as feasibly essential for MOR‐ligand ...
Graziella Tocco, Antonio Laus, Maksims Vanejevs, Anastasija Ture, Rafaela Mostallino, Nicholas Pintori, Maria Antonietta De Luca, M. Paola Castelli, Gaetano Di Chiara   +8 more
wiley   +1 more source

Effects of Fragmentary and Complete Extirpation of the Cerebellum in the Cat [PDF]

, 1932
G. W. T. H. Fleming
openalex   +1 more source

In Vivo Cytosolic Delivery of Biomolecules into Neurons for Super‐Resolution Imaging and Genome Modification

Advanced Science, EarlyView.
The N1 peptide specifically targets neurons, enabling cytosolic delivery of fluorescent dyes and proteins for super‐resolution imaging and functional genetic modification. Abstract Efficient delivery of biomolecules into neurons has significant impacts on therapeutic applications in the central nervous system (CNS) and fundamental neuroscience research.
Xiaoqian Ge, Joseph B. Wekselblatt, Scott Elmore, Bo Wang, Tongtong Wang, Renjinming Dai, Tingting Zhang, Harsh Dave, Mohammadaref Ghaderi, Athul Raj Anilkumar, Bill Wang, Shashank R. Sirsi, Jung‐Mo Ahn, Mikhail G. Shapiro, Yuki Oka, Carlos Lois, Zhenpeng Qin   +16 more
wiley   +1 more source

Cerebellar defects in Pdss2 conditional knockout mice during embryonic development and in adulthood

Neurobiology of Disease, 2012
PDSS2 is a gene that encodes one of the two subunits of trans-prenyl diphosphate synthase that is essential for ubiquinone biosynthesis. It is known that mutations in PDSS2 can cause primary ubiquinone deficiency in humans and a similar disease in mice ...
Song Lu, Lin-Yu Lu, Meng-Fei Liu, Qiu-Ju Yuan, Mai-Har Sham, Xin-Yuan Guan, Jian-Dong Huang   +6 more
doaj  

Morphometric development of the human fetal cerebellum during the early second trimester

NeuroImage, 2020
The protracted nature of development makes the cerebellum vulnerable to a broad spectrum of pathologic conditions, especially during the early fetal period. This study aims to characterize normal cerebellar growth in human fetuses during the early second
Feifei Xu, Xinting Ge, Yonggang Shi, Zhonghe Zhang, Yuchun Tang, Xiangtao Lin, Gaojun Teng, Fengchao Zang, Nuonan Gao, Haihong Liu, Arthur W. Toga, Shuwei Liu   +11 more
doaj  

The cerebellum in cases of lowered blood pressure and "shock," an experimental study [PDF]

, 1915
Amanda Allen
openalex   +1 more source

Intraoperative Fast Adaptive Focus Tracking Robotic OCT Enables Real‐Time Tumor Grading and Large‐Area Microvascular Imaging in Human Spinal Cord Surgery

Advanced Science, EarlyView.
The fast adaptive focus tracking robotic optical coherence tomography (FACT‐ROCT) offers real‐time, high‐resolution imaging of spinal cord tumors during surgery. By reducing motion artifacts with robotics and adaptive focal tracking, it accurately differentiates tumor grades using a novel attenuation coefficient marker and reveals critical ...
Bin He, Yuzhe Ying, Yejiong Shi, Zhe Meng, Zichen Yin, Zhengyu Chen, Zhangwei Hu, Ruizhi Xue, Linkai Jing, Yang Lu, Zhenxing Sun, Weitao Man, Youtu Wu, Dan Lei, Ning Zhang, Guihuai Wang, Ping Xue   +16 more
wiley   +1 more source

Measures of tonic and phasic activity of the locus coeruleus—norepinephrine system in children with autism spectrum disorder: An event‐related potential and pupillometry study

Autism Research, Volume 15, Issue 12, Page 2250-2264, December 2022., 2022
Abstract A growing body of research suggests that locus coeruleus‐norepinephrine (LC‐NE) system may function differently in individuals with autism spectrum disorder (ASD). Understanding the dynamics of both tonic (resting pupil diameter) and phasic (pupil dilation response [PDR] and event‐related potential [ERP]) indices may provide meaningful ...
Yesol Kim, Girija Kadlaskar, Rebecca McNally Keehn, Brandon Keehn   +3 more
wiley   +1 more source

New clues for the role of cerebellum in schizophrenia and the associated cognitive impairment

Frontiers in Cellular Neuroscience
Schizophrenia (SZ) is a complex neuropsychiatric disorder associated with severe cognitive dysfunction. Although research has mainly focused on forebrain abnormalities, emerging results support the involvement of the cerebellum in SZ physiopathology ...
Pawan Faris, Doris Pischedda, Fulvia Palesi, Egidio D’Angelo, Egidio D’Angelo   +4 more
doaj   +1 more source

The cerebellum of Amblystoma [PDF]

, 1920
O. Larsell
openalex   +1 more source