Results 191 to 200 of about 445,217 (392)
CASE OF CANCER OF THE RIGHT LOBE OF THE CEREBELLUM AND LEFT LENTICULAR NUCLEUS; MARKED VERTIGO; NO PARALYSIS [PDF]
, 1888 Byrom Bramwell
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A Drosophila model of prion disease and its metabolic changes in the brain
Animal Models and Experimental Medicine, EarlyView.We developed a Drosophila model for prion disease, and flies were capable of expressing the hamster prion protein (HaPrP) under the control of the GAL4/UAS system. The model exhibited some characteristics of the disease in mammals and displayed alterations in protein, sphingolipid, and carbohydrate metabolism. Preliminary applications have demonstrated
Dongdong Wang +14 more
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EFFECTS OF DIRECT APPLICATION OF CURARE TO VARIOUS PARTS OF THE CEREBELLUM [PDF]
, 1919 L. Stern, E Rothlin
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Establishment and evaluation of a novel rat model of the fourth ventricle hemorrhage
Animal Models and Experimental Medicine, EarlyView.In this study, a novel rat model of fourth ventricle hemorrhage was established via autologous blood injection through the foramen of Magendie. Anesthetized rats were positioned in a stereotaxic apparatus with their heads tilted downward at an angle of approximately 20° relative to the vertical axis.
Chuhua Fu +8 more
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.We generated two neuron‐specific Cre rat lines, Thy1‐Cre and NeuN‐Cre, using CRISPR/Cas9‐mediated targeted insertion. Both lines were validated for high neural specificity by crossing them with a Cre reporter rat. When bred with an ND1 conditional knockout rat, the two Cre lines produced distinct phenotypic outcomes. These rat lines have been deposited
Keru Li +15 more
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RECEIVING AREAS OF THE TACTILE, AUDITORY, AND VISUAL SYSTEMS IN THE CEREBELLUM
, 1944 Ray S. Snider, A Stowell
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Neuroimaging Biomarkers for Friedreich Ataxia: A Cross‐Sectional Analysis of the TRACK‐FA Study
Annals of Neurology, EarlyView.Objective We aimed to quantify differences in the brain and spinal cord between Friedreich ataxia and controls, stratified by age and disease stage, including for the first time in young children. Methods TRACK‐FA is the largest prospective, longitudinal, multi‐modal neuroimaging study in Friedreich ataxia to date.
Nellie Georgiou‐Karistianis +33 more
wiley +1 more source
Cholinergic Degeneration and Cognitive Function in Early GBA1‐Related Parkinson's Disease
Annals of Neurology, EarlyView.Objective The phenotype of patients with Parkinson's disease carrying GBA1 variants (GBA‐PD) suggest similarities to symptomatology associated with early cholinergic system degeneration. Therefore, this study aims to investigate the clinical features and the cholinergic innervation pattern in patients with early GBA‐PD versus those without the GBA1 ...
Sofie Slingerland +6 more
wiley +1 more source