Results 191 to 200 of about 355,853 (371)
Epilepsia Open, EarlyView., 2022 Abstract Epilepsy is a heterogeneous disorder characterized by spontaneous seizures and behavioral comorbidities. The underlying mechanisms of seizures and epilepsy across various syndromes lead to diverse clinical presentation and features. Similarly, animal models of epilepsy arise from numerous dissimilar inciting events.
Melissa Barker‐Haliski +3 more
wiley +1 more source
Effects on purkinje cells of surface stimulation of the cerebellum
, 1957 Raǵnar Granit, C. G. Phillips
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A CASE OF SCLEROTIC ATROPHY OF CEREBRUM AND CEREBELLUM, OF FAMILIAL TYPE, OCCURRING IN A BOY [PDF]
, 1902 MICHELL J. CLARKE
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American Journal of Medical Genetics Part A, EarlyView.ABSTRACT SETD2 has an essential role in epigenetic regulation. SETD2 pathogenic variants cause neurodevelopmental disorders (SETD2‐NDDs) that most commonly include various degrees of intellectual disability and behavioral disorders, macrocephaly, brain malformations, and generalized overgrowth.
Marie Lucain +11 more
wiley +1 more source
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT The MT‐ATP6 gene m.8993T>G pathogenic variant has been associated with Leigh syndrome, especially in patients exhibiting a high degree of heteroplasmy. Although patients may present with a wide phenotypic spectrum, characteristic findings include bilateral, symmetric hyperintensities in the basal ganglia and brainstem on brain MRI ...
Ramya Treitel +2 more
wiley +1 more source
New Transferrin Receptor‐Targeting Conjugate Effectively Delivers DNA to Mouse Brain
Angewandte Chemie, EarlyView.We present a novel RNA aptamer targeting the transferrin receptor (TfR), conjugated with DSPE lipid, which achieves remarkably efficient brain uptake, reaching brain‐to‐serum ratios as high as 6.5. Through fluorescence imaging and polymerase‐chain reaction analyses, we verify that this new conjugate successfully delivers a substantial amount of DNA ...
Min‐sun Song +8 more
wiley +2 more sources
RoboOS: A Hierarchical Embodied Framework for Cross-Embodiment and Multi-Agent Collaboration [PDF]
arXivThe dawn of embodied intelligence has ushered in an unprecedented imperative for resilient, cognition-enabled multi-agent collaboration across next-generation ecosystems, revolutionizing paradigms in autonomous manufacturing, adaptive service robotics, and cyber-physical production architectures.
arxiv
The Lettsomian Lectures ON THE CEREBELLUM AND ITS AFFECTIONS: Delivered before the Medical Society of London [PDF]
, 1910 J. S. Risien Russell
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Premenopausal bilateral oophorectomy and Alzheimer's disease imaging biomarkers later in life
Alzheimer's &Dementia, EarlyView.Abstract INTRODUCTION Premenopausal bilateral oophorectomy (PBO) before the age of 46 years is associated with an increased risk of dementia. We investigated the long‐term effects of PBO performed before age 50 years on amyloid beta (Aβ), tau, and neurodegeneration imaging biomarkers of Alzheimer's disease (AD).
Kejal Kantarci +13 more
wiley +1 more source