Results 141 to 150 of about 42,785 (261)

Presenilin L166P Mutation, a Model of Familial Alzheimer's Disease, Leads to Early Onset Bone Loss

Comprehensive Physiology, Volume 16, Issue 1, February 2026.
Female‐specific bone loss in Alzheimer's disease mouse models: There is a significant alteration of bone phenotype during Alzheimer's disease. Using integrated imaging and biological assays, we observed changes in the bone microarchitecture, composition, and function in PSEN K1 and PSEN1/hAPP Tg+ mice, predominantly in the females. ABSTRACT Accelerated
Vidyani Suryadevara, Connor J. Krehbial, Anuradha K. Valiya, Melinda Vang, Julian Balanta‐Melo, Pierre P. Eleniste, Sumana Posritong, Jung Min Hong, Katie Chester, Gabriel M. Pagnotti, Teresita Bellido, Monte S. Willis, Angela Bruzzaniti   +12 more
wiley   +1 more source

Causal Effect of Dietary Patterns on Cerebral Small Vessel Disease: A Mendelian Randomization Study

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
This Mendelian randomization (MR) study reveals causal links between dietary factors and cerebral small vessel disease (CSVD) neuroimaging markers. Genetically predicted higher polyunsaturated fatty acid (PUFA) levels reduce white matter hyperintensity volume, while monounsaturated fatty acid (MUFA) intake lowers lobar brain microbleeds (BMB) risk.
Yong Zeng, Ziqian Zhao, Hongyan Liu, Yijun Zeng, Song Xu, Shanjing Nie   +5 more
wiley   +1 more source

Cerebral amyloid angiopathy is associated with glymphatic transport reduction and time-delayed solute drainage along the neck arteries

Nature Aging, 2022
Xinan Chen, Xiaodan Liu, S. Koundal, Rena Elkin, Xiaoyue Zhu, Brittany Monte, Feng Xu, Feng Dai, M. Pedram, Hedok Lee, J. Kipnis, A. Tannenbaum, W. V. Van Nostrand, H. Benveniste   +13 more
semanticscholar   +1 more source

ApoA-I deficiency increases cortical amyloid deposition, cerebral amyloid angiopathy, cortical and hippocampal astrogliosis, and amyloid-associated astrocyte reactivity in APP/PS1 mice

Alzheimer's Research & Therapy, 2019
Alzheimer’s disease (AD) is defined by amyloid beta (Aβ) plaques and neurofibrillary tangles and characterized by neurodegeneration and memory loss.
Emily B Button, Guilaine K. Boyce, Anna Wilkinson, S. Stukas, Arooj Hayat, Jianjia Fan, Brennan J. Wadsworth, J. Robert, Kris M. Martens, C. Wellington   +9 more
semanticscholar   +1 more source

Noninvasive imaging of amyloid‐beta and tau in rodent and nonhuman primate models

VIEW, Volume 7, Issue 1, February 2026.
Imaging of amyloid‐beta plaque and tau accumulation in rodent and nonhuman primate model of Alzheimer's disease. Created in BioRender. Ni R. 2026. https://BioRender.com/a97h5ec Abstract Neurodegenerative diseases are characterized by the aberrant accumulation of protein aggregates.
Ruiqing Ni, Axel Rominger
wiley   +1 more source

A Collet–Sicard syndrome due to internal carotid artery dissection associated with cerebral amyloid angiopathy–related inflammation

SAGE Open Medical Case Reports, 2018
Background: Cerebral amyloid angiopathy–related inflammation is a rare condition with approximately 100 reported cases. Its clinical manifestations are varied. We report here a novel presentation of this disease.
Vanessa Saliou, Douraied Ben Salem, Julien Ognard, Dewi Guellec, Pascale Marcorelles, François Rouhart, Fabien Zagnoli, Serge Timsit   +7 more
doaj   +1 more source

Cerebral amyloid angiopathy interacts with neuritic amyloid plaques to promote tau and cognitive decline.

Brain : a journal of neurology, 2022
J. Rabin, E. Nichols, R. La Joie, K. Casaletto, P. Palta, K. Dams-O’Connor, Raj G. Kumar, K. George, C. Satizabal, J. Schneider, J. Pa, A. Brickman   +11 more
semanticscholar   +1 more source

Advances in cerebral amyloid angiopathy imaging

Therapeutic Advances in Neurological Disorders, 2019
Cerebral amyloid angiopathy (CAA) is a cerebral small vessel disease caused by β -amyloid (Aβ) deposition at the leptomeningeal vessel walls. It is a common cause of spontaneous intracerebral hemorrhage and a frequent comorbidity in Alzheimer’s disease ...
Szu-Ju Chen, Hsin-Hsi Tsai, Li-Kai Tsai, Sung-Chun Tang, Bo-Chin Lee, Hon-Man Liu, Ruoh-Fang Yen, Jiann-Shing Jeng   +7 more
doaj   +1 more source

Vascular β-amyloid and early astrocyte alterations impair cerebrovascular function and cerebral metabolism in transgenic arcAβ mice [PDF]

, 2018
Cerebrovascular lesions related to congophilic amyloid angiopathy (CAA) often accompany deposition of β-amyloid (Aβ) in Alzheimer's disease (AD), leading to disturbed cerebral blood flow and cognitive dysfunction, posing the question how cerebrovascular ...
Merlini, Mario, Meyer, Eric, Nitsch, Roger, Ulmann-Schuler, Alexandra   +3 more
core  

Association of angiitis of central nervous system, cerebral amyloid angiopathy, and Alzheimer’s disease: Report of an autopsy case

Vascular Health and Risk Management, 2008
Cédric Annweiler1, Marc Paccalin2, Gilles Berrut3, Caroline Hommet4, Christian Lavigne1, Jean-Paul Saint-André5, Olivier Beauchet11Department of Geriatrics and Internal Medicine, Angers University Hospital, France; 2Department of Geriatrics,
Cédric Annweiler, Marc Paccalin, Gilles Berrut, Caroline Hommet, Christian Lavigne, et al   +5 more
doaj