Results 121 to 130 of about 577,451 (225)

C1qc Mediates Blood–Brain Barrier Disruption in a Mouse Model of Intracerebral Haemorrhage Through Microglia‐Derived Migrasomes

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
Microglia‐derived migrasomes induce vascular endothelial pyroptosis through C1qc delivery, uncovering a novel mechanism of blood–brain barrier (BBB) disruption after intracerebral haemorrhage (ICH) and proposing a novel therapeutic strategy targeting extracellular vesicles (EVs).
Mengyuan Li, Zhihua Li, Dengpan Song, Fang Wang, Mengzhao Feng, Chi‐Tai Yeh, Tingting Zhai, Menghan Deng, Yanyan Sun, Junyang Wang, Xuemei Chen, Yating Wang, Qiong Yang, Moxin Wu, Xiaoping Yin, Junmin Wang, Jian Wang, Fuyou Guo   +17 more
wiley   +1 more source

2026 Asia Pacific Heart Rhythm Society (APHRS) Guidelines (Part II) on Stroke Prevention in Atrial Fibrillation

Journal of Arrhythmia, Volume 42, Issue 5, October 2026.
ABSTRACT The 2026 Asia Pacific Heart Rhythm Society (APHRS) Guidelines represent the first comprehensive APHRS guidelines dedicated to the management of atrial fibrillation (AF) and comprise four parts covering epidemiology, detection/screening and integrated care; stroke prevention; rate and rhythm control; and lifestyle risk factor and comorbidity ...
Tze‐Fan Chao, Gregory Y. H. Lip, Yi‐Hsin Chan, So‐Ryoung Lee, Mingfang Li, Daehoon Kim, Ling Kuo, Ken Okumura, Hung‐Fat Tse, Eue‐Keun Choi, Minglong Chen, Boyoung Joung, Rungroj Krittayaphong, Melissa E. Middeldorp, Kyoko Soejima, Hui‐Nam Pak   +15 more
wiley   +1 more source

Myelin Impairment and Regeneration in the Central Nervous System: Molecular Mechanisms, Diseases, and Prospective Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
Proper myelin formation is crucial for normal neural circuit function, while myelin deficiency can lead to neural circuit dysfunction and cognitive decline, notably in Alzheimer's disease and other central nervous system demyelinating disorders. This review summarizes central myelin's structure and function, demyelination biomarkers and pathological ...
Lihong Huang, Peng Cheng, Guangdong Liu, Yang Xiang, Zhen Hong, Weidong Le   +5 more
wiley   +1 more source

Progressive Amyloid‐Related Imaging Abnormalities After Discontinuation of Lecanemab in Early Alzheimer Disease in an APOE ε2/ε4 Carrier

European Journal of Neurology, Volume 33, Issue 10, October 2026.
ABSTRACT Background Amyloid‐related imaging abnormalities (ARIA) are the most relevant adverse events associated with anti‐amyloid therapies in Alzheimer's disease. Methods We report a case of progressive ARIA after discontinuation of lecanemab in a patient with early‐onset Alzheimer's disease carrying the rare APOE ε2/ε4 genotype.
Elisabeth Stögmann, Lukas Haider, Joel Leinkauf, Thomas Nakuz, Helena Untersteiner, Clemens Farr, Sara Silvaieh, Tandis Parvizi, Raphael Wurm, Gregor Kasprian, Thomas Berger, Ellen Gelpi, Evelyn Berger Sieczkowski   +12 more
wiley   +1 more source

Real‐World Patient Eligibility for Alzheimer's Disease Anti‐Amyloid Therapy in Seven Swedish Memory Clinics

European Journal of Neurology, Volume 33, Issue 10, October 2026.
Anti‐amyloid therapies lecanemab and donanemab are targeted at patients with early Alzheimer‐type dementia or mild cognitive impairment (MCI). In a large, Swedish multicenter memory clinic patient cohort, we found an eligibility rate of 11.5% for either treatment in the whole cohort (18.1% among dementia patients, 11.5% among aMCI patients), indicating
Anna Rosenberg, Anna Rennie, Urban Ekman, Makrina Daniilidou, Anette Hall, Anna Matton, Ari Solomon, Lars‐Olof Wahlund, Miia Kivipelto, Eric Westman   +9 more
wiley   +1 more source

Pathology-Proven Cerebral Amyloid Angiopathy in a Patient With Spontaneous Intracerebral Hemorrhage

Annals of Internal Medicine: Clinical Cases
Cerebral amyloid angiopathy (CAA)–related intracerebral hemorrhage (ICH) accounts for 20% of spontaneous ICH. Results of brain magnetic resonance imaging (MRI) support the clinical diagnosis of suspected CAA and help predict future ICH.
Muntadher Khaleefah, Mangay Thandampallayam, Hiba Al Dallal, Larry B. Goldstein, Kara Jo Swafford   +4 more
doaj   +1 more source

Leukoencephalopathy-Related Cerebral Amyloid Angiopathy With Cystatin C Deposition

, 1996
Background We have described sporadic cases of cerebral amyloid angiopathy with cerebral hemorrhage showing a low cystatin C level in the cerebrospinal fluid detected by enzyme-linked immunosorbent assay.
Atsushi Nagai, Kaoru Imaoka, Shotai Kobayashi, Koichi Shimode, Nobuyuki Umegae   +4 more
core   +1 more source

Associations Between Kidney Function and Risk of Cognitive Impairment Among Chinese Older Adults

Geriatrics &Gerontology International, Volume 26, Issue 10, October 2026.
This graphical abstract illustrates the association between kidney function and risk of cognitive impairment among Chinese older adults from the CLHLS cohort. Reduced eGFR and elevated ACR assessed at baseline were significantly associated with higher odds of both prevalent and incident cognitive impairment, after adjusting for sociodemographic and ...
Xin Wang, Yue Zhang, Zhigang Wang, Xiaolei Liu   +3 more
wiley   +1 more source

Cortical superficial siderosis and bleeding risk in cerebral amyloid angiopathy: multicentre MRI cohort study

, 2013
Cortical superficial siderosis and bleeding risk in cerebral amyloid angiopathy: multicentre MRI cohort ...
Y Vandermeeren (13445181), A Charidimou (13445172), DJ Werring (10872519), Anna Peeters (13058832), HR Jaeger (14478903), P Laloux (13444674), J-C Baron (13553830), Z Fox (13445256)   +7 more
core  

Cerebral amyloid angiopathy presenting with vasculitic pathology

, 2006
We present an elderly patient with an unusual extensive multifocal central nervous system mass lesion, with dramatic imaging changes but only minor disturbance of cerebral function.
Kermode, A.G., Wong, S.H., Robbins, P.D., Knuckey, N.W.   +3 more
core