Results 141 to 150 of about 46,178 (264)

Stroke caused by cerebral amyloid angiopathy: a case of difficult diagnosis [PDF]

Dementia & Neuropsychologia
. Cerebral amyloid angiopathy is a common cause of intracerebral hemorrhage, most often occurring in older adults and in patients with dementia. One of its main differential diagnoses is hypertensive intracerebral hemorrhage.
Rocío Campos Gamarra, Carla Villanueva Colina, Jimmy Palacios-García   +2 more
doaj   +1 more source

Blood-brain barrier leakage and microvascular lesions in cerebral amyloid angiopathy

Stroke, 2019
Background and Purpose— Cerebral amyloid angiopathy (CAA) is a common small vessel disease that independently effects cognition in older individuals. The pathophysiology of CAA and CAA-related bleeding remains poorly understood. In this postmortem study,
W. Freeze, B. Bacskai, M. Frosch, H. Jacobs, W. Backes, S. Greenberg, Susanne J. van Veluw   +6 more
semanticscholar   +1 more source

Multiscale Approximations to Understand the Complex Role of Microglia in Alzheimer's Disease

European Journal of Neuroscience, Volume 63, Issue 9, May 2026.
Microglia are dynamic, context‐dependent regulators of Alzheimer's disease, modulating amyloid, tau, and neurodegeneration across disease stages. Integrating multiscale and human‐focused approaches is essential to translate microglial biology into therapeutic strategies. ABSTRACT Microglia, the resident innate immune cells of the central nervous system,
Patricia Martínez‐Tazo, Marina Mejias‐Ortega, Verónica López‐López, Aysha M. Bhojwani‐Cabrera, Emma Saxton, Santiago Canals, Giles Hardingham, Antonia Gutierrez, Jose P. Lopez‐Atalaya, Silvia De Santis   +9 more
wiley   +1 more source

Amyloid-related imaging abnormalities (ARIA) in Alzheimer’s disease: from pathophysiology to individualized risk assessment

Alzheimer’s Research & Therapy
Monoclonal antibodies targeting amyloid-β are the first approved disease-modifying treatment for Alzheimer’s disease. While amyloid-targeting therapies mitigate the progression of cognitive decline in early-stage Alzheimer’s disease, they are associated ...
Jonathan Merkel, Robert Perneczky, Frank Jessen, Lutz Frölich, Olav Jansen, Sönke Peters, Daniela Berg, Jörg B. Schulz, Thorsten Bartsch   +8 more
doaj   +1 more source

Cerebrospinal Fluid Aβ Biomarkers Predict Recurrent Hemorrhage and Identify Cerebral Amyloid Angiopathy in Patients With Lobar Hemorrhage

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Recurrent hemorrhage represents a significant risk for patients with lobar hemorrhage and underlying cerebral amyloid angiopathy. However, it remains unknown, whether cerebrospinal fluid biomarkers of β‐amyloid (Aβ) retention, predict ...
Philipp Arndt, Malte Pfister, Frank Schreiber, Valentina Perosa, Hendrik Mattern, Jose Bernal, Berkant Bay, Marc Dörner, Marwa Al‐Dubai, Vanessa Swiatek, Belal Neyazi, Erol Sandalcioglu, Cornelia Garz, Sven G. Meuth, Michael Goertler, Stefan Vielhaber, Katja Neumann, Stefanie Schreiber   +17 more
doaj   +1 more source

The increasing impact of cerebral amyloid angiopathy: essential new insights for clinical practice

Journal of Neurology Neurosurgery & Psychiatry, 2017
Cerebral amyloid angiopathy (CAA) has never been more relevant. The last 5 years have seen a rapid increase in publications and research in the field, with the development of new biomarkers for the disease, thanks to advances in MRI, amyloid positron ...
G. Banerjee, R. Carare, C. Cordonnier, S. Greenberg, J. Schneider, Eric E. Smith, M. van Buchem, J. van der Grond, M. Verbeek, D. Werring   +9 more
semanticscholar   +1 more source

CSF Biomarker Profile of Cerebral Amyloid Angiopathy: Diagnostic Performance and Imaging Correlates in a Hospital‐Based Neurology Cohort

European Journal of Neurology, Volume 33, Issue 5, May 2026.
Cerebral amyloid angiopathy (CAA) frequently coexists with Alzheimer's disease (AD), complicating diagnosis in patients with cognitive impairment. In this hospital‐based cohort including healthy controls, CAA, AD, and mixed CAA‐AD cases, CSF Aβ40 and Aβ42 provided complementary diagnostic value for identifying CAA. Lower CSF Aβ40 levels were associated
Aida Fernández‐Lebrero, Joan Jiménez‐Balado, Greta García‐Escobar, José Contador, Isabel Estraguès‐Gázquez, Laia Peraferrer‐Montesinos, Antoni Suárez‐Pérez, Rosa María Manero‐Borràs, Brigitte Beltrán, Ludovica Gramegna, Ana Rodríguez Campello, Abel Palacio‐Gili, Oriol Grau, Marc Suárez‐Calvet, Angel Ois, Albert Puig‐Pijoan, Irene Navalpotro‐Gómez   +16 more
wiley   +1 more source

Pleiotropic neuroprotective effects of taxifolin in cerebral amyloid angiopathy

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Cerebrovascular amyloid-β deposition is highly implicated in the pathogenesis of cerebral amyloid angiopathy (CAA), one of the major causes of dementia.
Takayuki Inoue, S. Saito, Masashi Tanaka, H. Yamakage, T. Kusakabe, A. Shimatsu, M. Ihara, N. Satoh‐Asahara   +7 more
semanticscholar   +1 more source

Correlation between the neutrophil‐to‐lymphocyte ratio and enlarged perivascular spaces in type 2 diabetes mellitus

Journal of Diabetes Investigation, Volume 17, Issue 5, Page 844-850, May 2026.
ABSTRACT Aims To determine the relationship between the neutrophil‐to‐lymphocyte ratio and enlarged perivascular spaces in patients with type 2 diabetes mellitus. Materials and Methods Cranial magnetic resonance imaging data from 200 patients with type 2 diabetes mellitus were analyzed to categorize enlarged perivascular spaces in the basal ganglia and
Wei Zhang, Zhen Wang, Yaping Sun, Shaofeng Xu, Lei Zhu, Xiaolei Li   +5 more
wiley   +1 more source

Validation of machine learning models to detect amyloid pathologies across institutions. [PDF]

, 2020
Semi-quantitative scoring schemes like the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) are the most commonly used method in Alzheimer's disease (AD) neuropathology practice.
Dugger, Brittany N, Gearing, Marla, Glass, Jonathan D, Gutman, David A, Keiser, Michael J, Vizcarra, Juan C   +5 more
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