Results 101 to 110 of about 46,178 (264)

Association of TDP-43 proteinopathy, cerebral amyloid angiopathy, and Lewy bodies with cognitive impairment in individuals with or without Alzheimer’s disease neuropathology

Scientific Reports, 2020
Alzheimer’s disease patients typically present with multiple co-morbid neuropathologies at autopsy, but the impact of these pathologies on cognitive impairment during life is poorly understood.
David X. Thomas, Sumali Bajaj, K. McRae‐McKee, C. Hadjichrysanthou, Roy M. Anderson, J. Collinge   +5 more
semanticscholar   +1 more source

Contributions of vascular ageing to late‐onset Alzheimer's disease

Experimental Physiology, EarlyView.
Abstract Late‐onset Alzheimer's disease (LOAD) is an age‐related disease that is strongly associated with vascular risk factors and cerebrovascular impairments. As such, changes in the vasculature with advancing age likely contribute to LOAD, but the mechanisms underlying these contributions remain incompletely understood.
Skylyn J. Ferguson, Young Deanna Choi, Ashley E. Walker   +2 more
wiley   +1 more source

From Vessels to Cognition: Glymphatic Alterations Following Hemorrhage in Cerebral Amyloid Angiopathy Are Associated With Small Vessel Disease Burden

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Cerebral amyloid angiopathy–related hemorrhage is associated with both cerebral small vessel disease (CSVD) pathology and long‐term cognitive decline. The role of glymphatic dysfunction in mediating this relationship remains unclear. Methods A
Yijun Lin, Sijia Li, Yang Du, Mengyao Li, Yanfang Liu, Xingquan Zhao   +5 more
doaj   +1 more source

Cerebral amyloid angiopathy (case report)

Анналы клинической и экспериментальной неврологии, 2017
Cerebral amyloid angiopathy (CAA) is characterized by -amyloid deposition in cortical and leptomeningeal arteries of small and medium size that disturbs normal structure of arterial wall.
L. A. Dobrynina, L. A. Kalashnikova, R. N. Konovalov, A. S. Kadykov   +3 more
doaj   +1 more source

Hypertension-Related Cerebral Microbleeds

Case Reports in Neurology, 2020
Hypertension and cerebral amyloid angiopathy are the most common causes of cerebral microbleeds. The pattern of microbleeds on T2*-weighted gradient echo sequence of magnetic resonance imaging of the brain can be indicative of the etiology of ...
Sujan T. Reddy, Sean I. Savitz
doaj   +1 more source

The Importance of Neuropathology in a Complex Movement Disorder with Primary Familial Brain Calcification

Movement Disorders, EarlyView.
Ida Gugler, Per Svenningsson, Inger Nennesmo, Martin Paucar   +3 more
wiley   +1 more source

Amyloid β alters vascular CaV1.2 channel spatiotemporal properties

The Journal of Physiology, EarlyView.
Abstract figure legend Amyloid‐β1‐42 (Aβ1‐42) triggers a male‐specific signalling cascade influencing CaV1.2 spatiotemporal properties in cerebral vascular smooth muscle. The signalling pathway involves NADPH oxidase (NOX)‐derived reactive oxygen species (ROS) activation of protein kinase C (PKC). Aβ1‐42 can also activate protein kinase A (PKA).
Jade L. Taylor, Miguel Martin‐Aragon Baudel, Eric Pereira da Silva, Johannes W. Hell, Madeline Nieves‐Cintron, Manuel F. Navedo   +5 more
wiley   +1 more source

Cerebrospinal fluid biomarkers in cerebral amyloid angiopathy: insights from a clinical case series

Arquivos de Neuro-Psiquiatria
Cerebral amyloid angiopathy (CAA) is a small vessel disease characterized by the deposition of amyloid-beta in small cerebral vessels, which can lead to intracerebral hemorrhages and cognitive impairment.
Ana Silvia Sobreira Lima Verde, Alessandra Braga Cruz Guedes de Morais, Amanda Vale Catunda, João Igor Dantas Landim, Ian Silva Ribeiro, Bruno Diógenes Iepsen, Norberto Anízio Ferreira Frota   +6 more
doaj   +1 more source

Monoaminergic Neuropathology in Alzheimer's disease [PDF]

, 2016
Acknowledgments This work was supported by The Croatian Science Foundation grant. no. IP-2014-09-9730 (“Tau protein hyperphosphorylation, aggregation, and trans-synaptic transfer in Alzheimer’s disease: cerebrospinal fluid analysis and assessment of ...
Bažadona, Danira, Buée, Luc, Delalle, Ivana, Giovanni, Giuseppe Di, Harrington, Charles R., Hof, Patrick R., Jovanov-Milošević, Nataša, Leko, Mirjana Babić, Silva, Rohan de, Wischik, Claude M., Wray, Selina, Šimić, Goran   +11 more
core   +1 more source

Dystrophinopathy with a DMD exon 49–50 deletion in a female patient who developed schizophrenia: An autopsy case

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 2, June 2026.
Abstract Background Mutations in DMD affect not only muscles but also the brain. Cases of schizophrenia with DMD mutations have been described previously. Although female dystrophinopathy often has a milder phenotype, some affected females also have intellectual disabilities and psychiatric disorders.
Shusei Arafuka, Youta Torii, Ayako Miwa, Itaru Kushima, Hirotaka Sekiguchi, Hiroshige Fujishiro, Chikako Habuchi, Hiroaki Miyahara, Yosuke Kawai, Ran Wei, Katsushi Tokunaga, Norio Ozaki, Mari Yoshida, Shuji Iritani, Yasushi Iwasaki, Masashi Ikeda   +15 more
wiley   +1 more source