Results 91 to 100 of about 46,178 (264)

New perspectives on VEGF signalling in Alzheimer's disease

Brain Pathology, EarlyView.
Emery et al. bring together findings from recent multi‐omic studies, including single‐cell mRNA analysis of human post‐mortem brain tissue, and proteomic analysis of matched CSF and blood samples in large clinical studies. The authors present evidence of the involvement of altered VEGF signalling in vascular and immune dysfunction and neurodegeneration
Cherelle E. G. Emery, Seth Love, J. Scott Miners   +2 more
wiley   +1 more source

Cerebral amyloid angiopathy revealed by severe renal failure: A case report

Radiology Case Reports
Sporadic cerebral amyloid angiopathy is a common condition in the elderly, characterised by the accumulation of amyloid Aβ peptide in the walls of small cerebral arteries, leading to intracranial haemorrhage and cognitive impairment.
El Ouazzani Mouad, Bouchoual Mohammed, Boughmi Amine, Bounabe Rabia, Bigi Soufiane, Anibar Sara, Jabrane Marouane, Wakrim Soukaina, Arrayhani Mohamed   +8 more
doaj   +1 more source

Amyloid Precursor Protein Variant, E665D, Associated With Unique Clinical and Biomarker Phenotype

American Journal of Alzheimer's Disease and Other Dementias, 2021
We describe a clinical, imaging and biomarker phenotype associated with an amyloid precursor gene (APP) E665D variant in a 45-year-old man with progressive cognitive and behavioral dysfunction.
Justin R. Abbatemarco MD, Stephen E. Jones MD, PhD, Mykol Larvie MD, Lynn M. Bekris PhD, Maria E. Khrestian MS, Kamini Krishnan PhD, James B. Leverenz MD   +6 more
doaj   +1 more source

Pathophysiology of hypoperfusion of the precuneus in early Alzheimer’s disease [PDF]

, 2015
The earliest decline in cerebral perfusion in Alzheimer's disease (AD) is in the medial parietal cortex (precuneus). We have analyzed precuneus in post‐mortem tissue from 70 AD and 37 control brains to explore the pathophysiology of the hypoperfusion ...
Love, Seth, Miners, J Scott, Palmer, Jennifer C   +2 more
core   +2 more sources

Human brain matters: Navigating the neuropathology of COVID‐19

Brain Pathology, EarlyView.
Severe COVID‐19 is associated with vascular dysregulation and chronic neuroinflammation, leading to axonal injury and neurodegeneration. In long COVID or PASC, persistent alterations in neuroimaging and biofluid biomarkers reflect ongoing neuronal damage and neuroinflammation, contributing to long‐term neurological symptoms including fatigue, cognitive
Juliana M. Nieuwland, Angelica Scaramuzza, Marianna Bugiani, Wilma D. J. van de Berg, Jinte Middeldorp   +4 more
wiley   +1 more source

Dense-core senile plaques in the Flemish variant of Alzheimer's disease are vasocentric [PDF]

, 2002
Alzheimer's disease (AD) is characterized by deposition of beta-amyloid (Abeta) in diffuse and senile plaques, and variably in vessels. Mutations in the Abeta-encoding region of the amyloid precursor protein (APP) gene are frequently associated with very
Broeckhoven, C. (Christine) van, Ceuterick, C., Cras, P. (Patrick), Duijn, C.M. (Cornelia) van, Kros, J.M. (Johan), Kumar-Singh, S. (Samir), Lubke, U., Marck, E.A. (Eric) van, Martin, J-J. (Jean-Jacques), Serneels, S. (Sally), Swieten, J.C. (John) van, Timmermans, J.P., Vennekens, K., Wang, R. (Rong)   +13 more
core   +1 more source

Wasteosomes accumulate in periventricular white matter hyperintensities and exhibit complex relationships with mixed pathology, sclerotic index, and perivascular space

Brain Pathology, EarlyView.
In a mixed diagnostic cohort of pathologically diagnosed Alzheimer's disease, cerebrovascular disease, mixed pathology, and control tissue, we connected the histopathological wasteosome profile in periventricular (PV) brain sections to 7T FLAIR‐MRI confirmed PV white matter hyperintensities (WMHs), vascular stenosis and perivascular space size ...
Nikita Ollen‐Bittle, Isabella Boesgaard, Austyn Roseborough, Meaghan Frank, Qi Zhang, Stephen H. Pasternak, Robert Hammond, Shawn N. Whitehead   +7 more
wiley   +1 more source

Cerebral Amyloid Angiopathy and Blood-Brain Barrier Dysfunction

The Neuroscientist, 2020
Cerebral hemorrhage, a devastating subtype of stroke, is often caused by hypertension and cerebral amyloid angiopathy (CAA). Pathological evidence of CAA is detected in approximately half of all individuals over the age of 70 and is associated with ...
Monica Gireud-Goss, Alexis F. Mack, L. McCullough, A. Urayama   +3 more
semanticscholar   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, EarlyView.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

Normal pressure hydrocephalus and cerebral amyloid angiopathy: a set of diseases or the unity of pathogenesis?

Неврология, нейропсихиатрия, психосоматика, 2020
Idiopathic normal pressure hydrocephalus (NPH) is cerebral ventriculomegaly characterized by a wide range of controversial issues related to the prevalence of the disease, the mechanisms of its development, and nosological independence. Developing in old
E. G. Mendelevich
doaj   +1 more source