Results 71 to 80 of about 15,276 (177)

An unexpected discovery of a novel potentially pathogenic APP gene variant: a case report of slowly progressive Alzheimer’s disease with prominent cerebral amyloid angiopathy

Frontiers in Neuroscience
Amyloid precursor protein (APP) plays an essential role in brain function and development. Variants in the APP gene are associated with both familial Alzheimer’s disease and cerebral amyloid angiopathy. We report a case of early onset, slowly progressive
Matyas Sykora, Matyas Sykora, Matyas Sykora, Marie Harmackova, Eva Parobkova, Eva Parobkova, Robert Rusina, Robert Rusina, Radoslav Matěj, Radoslav Matěj, Radoslav Matěj   +10 more
doaj   +1 more source

Biomarker‐Based Diagnosis and Care Pathways for Alzheimer's Disease in the Era of Disease‐Modifying Treatments: A Consensus Statement by Belgian Experts

European Journal of Neurology, Volume 33, Issue 8, August 2026.
ABSTRACT Background The recent approval of disease‐modifying therapies (DMTs) for early Alzheimer's disease (AD) marks a major shift in clinical practice. Biomarker confirmation of amyloid pathology is now required alongside clinical assessment, and blood‐based tests are improving accessibility.
Tim Van Langenhove, Sara Van Mossevelde, Marijke Miatton, Jan De Lepeleire, Rose Bruffaerts, Jean Christophe Bier, Kurt Segers, Jurn Verschraegen, Mirko Petrovic, Manfredi Ventura, Haroun Jedidi, Ingo Beyer, Eric Mormont, Rik Vandenberghe, Aline Delva, Christian Gilles, Donatienne Van Weehaeghe, Gaëtane Picard, Peter De Deyn, Mélanie Strauss, Evert Thiery, Eric Salmon, Gert Cypers, Joris Vlaemynck, Katrin Gillis, Jan Versijpt, Maria Bjerke, Anne Sieben, Bernard Hanseeuw, Sebastiaan Engelborghs, Olivier Deryck, on behalf of the BeDeCo members   +31 more
wiley   +1 more source

Cerebrospinal Fluid Aβ Biomarkers Predict Recurrent Hemorrhage and Identify Cerebral Amyloid Angiopathy in Patients With Lobar Hemorrhage

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Recurrent hemorrhage represents a significant risk for patients with lobar hemorrhage and underlying cerebral amyloid angiopathy. However, it remains unknown, whether cerebrospinal fluid biomarkers of β‐amyloid (Aβ) retention, predict ...
Philipp Arndt, Malte Pfister, Frank Schreiber, Valentina Perosa, Hendrik Mattern, Jose Bernal, Berkant Bay, Marc Dörner, Marwa Al‐Dubai, Vanessa Swiatek, Belal Neyazi, Erol Sandalcioglu, Cornelia Garz, Sven G. Meuth, Michael Goertler, Stefan Vielhaber, Katja Neumann, Stefanie Schreiber   +17 more
doaj   +1 more source

Unravelling the Significance of Cystatin C and Bunina Bodies in Amyotrophic Lateral Sclerosis Pathogenesis

Neuropathology and Applied Neurobiology, Volume 52, Issue 4, August 2026.
ABSTRACT Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is a fatal neurodegenerative disease primarily affecting motor neurons. Two key protein inclusions found in lower motor neurons serve as neuropathological hallmarks of the disease in human tissue: the TDP43‐positive inclusion and the cystatin C‐positive Bunina body.
Sarah M. Granger, Rosemary A. Staniforth, Asbjorg Osk Snorradottir, Johnathan Cooper‐Knock, Kurt J. De Vos, J. Robin Highley   +5 more
wiley   +1 more source

Stroke caused by cerebral amyloid angiopathy: a case of difficult diagnosis [PDF]

Dementia & Neuropsychologia
. Cerebral amyloid angiopathy is a common cause of intracerebral hemorrhage, most often occurring in older adults and in patients with dementia. One of its main differential diagnoses is hypertensive intracerebral hemorrhage.
Rocío Campos Gamarra, Carla Villanueva Colina, Jimmy Palacios-García   +2 more
doaj   +1 more source

A First‐In‐Class Antibody Enabling Detection of Altered Peripheral Non‐Phosphorylated Clusterin With Translational Potential in Dementia

The FASEB Journal, Volume 40, Issue 14, 31 July 2026.
Non‐phosphorylated clusterin is decreased in the serum of dementia patients but not in Parkinson's disease, and phosphorylated clusterin in serum does not originate from the brain. 3D3F10, a monoclonal antibody specific to non‐phosphorylated clusterin, enables modification‐specific detection with diagnostic potential for dementia.
Hejie Li, Yu Li, Wenping Liang, Liyong Wu, Chao Han, Qianxu Ren, Xi Liu, Yanning Cai, Zhe Wang   +8 more
wiley   +1 more source

Amyloid-related imaging abnormalities (ARIA) in Alzheimer’s disease: from pathophysiology to individualized risk assessment

Alzheimer’s Research & Therapy
Monoclonal antibodies targeting amyloid-β are the first approved disease-modifying treatment for Alzheimer’s disease. While amyloid-targeting therapies mitigate the progression of cognitive decline in early-stage Alzheimer’s disease, they are associated ...
Jonathan Merkel, Robert Perneczky, Frank Jessen, Lutz Frölich, Olav Jansen, Sönke Peters, Daniela Berg, Jörg B. Schulz, Thorsten Bartsch   +8 more
doaj   +1 more source

Cerebral amyloid angiopathy: an update

Journal of Neurology, 2023
Schroeder, B. E., Robertson, N. P., Hughes, T. A. T.   +2 more
openaire   +2 more sources

Cerebral amyloid angiopathy: one single entity?

Current Opinion in Neurology
Purpose of review Cerebral amyloid angiopathy (CAA) is a common brain disorder among the elderly and individuals with Alzheimer's disease, where accumulation of amyloid-ß can lead to intracerebral hemorrhage and dementia. This review discusses recent developments in understanding the pathophysiology and phenotypes of CAA.
Koemans, E.A., Etten, E.S. van
openaire   +3 more sources

Association of angiitis of central nervous system, cerebral amyloid angiopathy, and Alzheimer’s disease: Report of an autopsy case

Vascular Health and Risk Management, 2008
Cédric Annweiler1, Marc Paccalin2, Gilles Berrut3, Caroline Hommet4, Christian Lavigne1, Jean-Paul Saint-André5, Olivier Beauchet11Department of Geriatrics and Internal Medicine, Angers University Hospital, France; 2Department of Geriatrics,
Cédric Annweiler, Marc Paccalin, Gilles Berrut, Caroline Hommet, Christian Lavigne, et al   +5 more
doaj