Results 71 to 80 of about 577,451 (225)

Normal pressure hydrocephalus and cerebral amyloid angiopathy: a set of diseases or the unity of pathogenesis?

Неврология, нейропсихиатрия, психосоматика, 2020
Idiopathic normal pressure hydrocephalus (NPH) is cerebral ventriculomegaly characterized by a wide range of controversial issues related to the prevalence of the disease, the mechanisms of its development, and nosological independence. Developing in old
E. G. Mendelevich
doaj   +1 more source

Rethinking diabetic retinopathy: Homeostatic mechanisms for retinal clearance

Diabetic Medicine, EarlyView.
In the healthy retina, balanced production and clearance of metabolic waste and fluid maintain retinal homeostasis and normal visual function. Diabetes disrupts this balance, increasing the accumulation of metabolic waste products, including advanced glycation end products (AGEs) and advanced lipoxidation end products (ALEs), while impairing waste and ...
Karis Little, Judith Lechner, Giulia De Rossi, Tara Cullen, Jennifer Perais, Eleni Beli, Noemi Lois, Alan W. Stitt   +7 more
wiley   +1 more source

From Vessels to Cognition: Glymphatic Alterations Following Hemorrhage in Cerebral Amyloid Angiopathy Are Associated With Small Vessel Disease Burden

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Cerebral amyloid angiopathy–related hemorrhage is associated with both cerebral small vessel disease (CSVD) pathology and long‐term cognitive decline. The role of glymphatic dysfunction in mediating this relationship remains unclear. Methods A
Yijun Lin, Sijia Li, Yang Du, Mengyao Li, Yanfang Liu, Xingquan Zhao   +5 more
doaj   +1 more source

Cerebral amyloid angiopathy (case report)

Анналы клинической и экспериментальной неврологии, 2017
Cerebral amyloid angiopathy (CAA) is characterized by -amyloid deposition in cortical and leptomeningeal arteries of small and medium size that disturbs normal structure of arterial wall.
L. A. Dobrynina, L. A. Kalashnikova, R. N. Konovalov, A. S. Kadykov   +3 more
doaj   +1 more source

Hypertension-Related Cerebral Microbleeds

Case Reports in Neurology, 2020
Hypertension and cerebral amyloid angiopathy are the most common causes of cerebral microbleeds. The pattern of microbleeds on T2*-weighted gradient echo sequence of magnetic resonance imaging of the brain can be indicative of the etiology of ...
Sujan T. Reddy, Sean I. Savitz
doaj   +1 more source

A validated deep learning workflow for 3D quantification of amyloid plaques in cleared mouse brain

Journal of Microscopy, EarlyView.
Abstract Accurate quantification of amyloid plaque pathology is essential for understanding Alzheimer's disease (AD) progression and evaluating therapeutic interventions. Yet, conventional histology relies on sampling thin tissue sections and therefore incompletely captures three‐dimensional (3D) plaque distributions, introducing bias and limiting ...
Veronika Valova, Louise Cole, Neftali Flores Rodriguez, Filip Braet, Daniel M. Johnstone, Richard Harwood   +5 more
wiley   +1 more source

CEREBRAL AMYLOID ANGIOPATHY RELATED INFLAMMATION – TWO CASES

Cerebral amyloid angiopathy-related inflammation is a rare but increasingly recognized subtype of cerebral amyloid angiopathy with distinctive clinical and imaging findings.
Yıldız, Bülent, Ceylan, Ömer Numan, KAYIM YILDIZ, ÖZLEM, YILDIZ, BÜLENT, Yıldız, Özlem Kayım, Kanat, Sümeyra   +5 more
core   +1 more source

Cerebrospinal fluid biomarkers in cerebral amyloid angiopathy: insights from a clinical case series

Arquivos de Neuro-Psiquiatria
Cerebral amyloid angiopathy (CAA) is a small vessel disease characterized by the deposition of amyloid-beta in small cerebral vessels, which can lead to intracerebral hemorrhages and cognitive impairment.
Ana Silvia Sobreira Lima Verde, Alessandra Braga Cruz Guedes de Morais, Amanda Vale Catunda, João Igor Dantas Landim, Ian Silva Ribeiro, Bruno Diógenes Iepsen, Norberto Anízio Ferreira Frota   +6 more
doaj   +1 more source

Contributions of vascular ageing to late‐onset Alzheimer's disease

Experimental Physiology, EarlyView.
Abstract Late‐onset Alzheimer's disease (LOAD) is an age‐related disease that is strongly associated with vascular risk factors and cerebrovascular impairments. As such, changes in the vasculature with advancing age likely contribute to LOAD, but the mechanisms underlying these contributions remain incompletely understood.
Skylyn J. Ferguson, Young Deanna Choi, Ashley E. Walker   +2 more
wiley   +1 more source

Amyloid β alters vascular CaV1.2 channel spatiotemporal properties

The Journal of Physiology, EarlyView.
Abstract figure legend Amyloid‐β1‐42 (Aβ1‐42) triggers a male‐specific signalling cascade influencing CaV1.2 spatiotemporal properties in cerebral vascular smooth muscle. The signalling pathway involves NADPH oxidase (NOX)‐derived reactive oxygen species (ROS) activation of protein kinase C (PKC). Aβ1‐42 can also activate protein kinase A (PKA).
Jade L. Taylor, Miguel Martin‐Aragon Baudel, Eric Pereira da Silva, Johannes W. Hell, Madeline Nieves‐Cintron, Manuel F. Navedo   +5 more
wiley   +1 more source