Results 51 to 60 of about 15,276 (177)

Cerebral amyloid angiopathy (case report)

Анналы клинической и экспериментальной неврологии, 2017
Cerebral amyloid angiopathy (CAA) is characterized by -amyloid deposition in cortical and leptomeningeal arteries of small and medium size that disturbs normal structure of arterial wall.
L. A. Dobrynina, L. A. Kalashnikova, R. N. Konovalov, A. S. Kadykov   +3 more
doaj   +1 more source

Hypertension-Related Cerebral Microbleeds

Case Reports in Neurology, 2020
Hypertension and cerebral amyloid angiopathy are the most common causes of cerebral microbleeds. The pattern of microbleeds on T2*-weighted gradient echo sequence of magnetic resonance imaging of the brain can be indicative of the etiology of ...
Sujan T. Reddy, Sean I. Savitz
doaj   +1 more source

Amyloid β alters vascular CaV1.2 channel spatiotemporal properties

The Journal of Physiology, EarlyView.
Abstract figure legend Amyloid‐β1‐42 (Aβ1‐42) triggers a male‐specific signalling cascade influencing CaV1.2 spatiotemporal properties in cerebral vascular smooth muscle. The signalling pathway involves NADPH oxidase (NOX)‐derived reactive oxygen species (ROS) activation of protein kinase C (PKC). Aβ1‐42 can also activate protein kinase A (PKA).
Jade L. Taylor, Miguel Martin‐Aragon Baudel, Eric Pereira da Silva, Johannes W. Hell, Madeline Nieves‐Cintron, Manuel F. Navedo   +5 more
wiley   +1 more source

Cerebrospinal fluid biomarkers in cerebral amyloid angiopathy: insights from a clinical case series

Arquivos de Neuro-Psiquiatria
Cerebral amyloid angiopathy (CAA) is a small vessel disease characterized by the deposition of amyloid-beta in small cerebral vessels, which can lead to intracerebral hemorrhages and cognitive impairment.
Ana Silvia Sobreira Lima Verde, Alessandra Braga Cruz Guedes de Morais, Amanda Vale Catunda, João Igor Dantas Landim, Ian Silva Ribeiro, Bruno Diógenes Iepsen, Norberto Anízio Ferreira Frota   +6 more
doaj   +1 more source

New perspectives on VEGF signalling in Alzheimer's disease

Brain Pathology, Volume 36, Issue 5, September 2026.
Emery et al. bring together findings from recent multi‐omic studies, including single‐cell mRNA analysis of human post‐mortem brain tissue, and proteomic analysis of matched CSF and blood samples in large clinical studies. The authors present evidence of the involvement of altered VEGF signalling in vascular and immune dysfunction and neurodegeneration
Cherelle E. G. Emery, Seth Love, J. Scott Miners   +2 more
wiley   +1 more source

Cerebrospinal Fluid β‐Amyloid and τ Levels in Patients With Iatrogenic Cerebral Amyloid Angiopathy, Sporadic Cerebral Amyloid Angiopathy, Alzheimer Disease, and Controls

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Iatrogenic cerebral amyloid angiopathy (iCAA) is a subform of cerebral amyloid angiopathy caused by exposure to amyloid β. The aim of this study was to assess cerebrospinal fluid amyloid and τ concentrations in iCAA in comparison with sporadic
Ulf Jensen‐Kondering, Nils G. Margraf, Slaven Pikija, Kinga Rak‐Frattner, Branko Malojcic, Senta Frol, Janja Pretnar‐Oblak, Patricia de la Riva, Ines Albajar Gomez, Jacopo C. DiFrancesco, Anna Bersano, Gregor Kuhlenbäumer, Benedetta Storti   +12 more
doaj   +1 more source

Amyloid Spells and High Blood Pressure: Imminent Danger

Case Reports in Neurology, 2014
We present the case of a 71-year-old male, admitted after a generalized tonic-clonic seizure, with a history of recurrent left arm and face paresthesias, associated with sulcal cortical subarachnoid hemorrhages. During the next 48 h, he remained agitated
Andre Caetano, Miguel Pinto, Sofia Calado, Miguel Viana-Baptista   +3 more
doaj   +1 more source

Early identification of vascular cognitive impairment from a multimodal perspective: a combined diagnosis from targeted cognitive assessments, imaging biomarkers, and molecular fluid biomarkers to ecological behavioral characteristics

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract Vascular cognitive impairment (VCI), the second leading cause of dementia, is characterized by heterogeneous pathophysiology and a potentially reversible early phase, underscoring the need for timely identification. This review synthesizes advances across four complementary domains – targeted cognitive assessments, imaging biomarkers ...
Wenqi Song, Xiaoqun Liu, Tianrui Yu, Yuanyuan Xiang, Peijie Fu, Moxin Wu, Xiaoping Yin, Xiaorong Zhang, Zhiying Chen   +8 more
wiley   +1 more source

Cerebral inflammatory amyloid angiopathy: response to treatment [PDF]

Dementia & Neuropsychologia
Cerebral Amyloid Angiopathy (CAA) is a small vessel disease associated with β-amyloid (Aβ) deposition in cortical and leptomeningeal vessels. Traditionally diagnosed through invasive methods, it can now be identified via advanced imaging modalities ...
João Roberto Ribeiro Pimenta, Júlian Letícia Freitas, Maria Sheila Guimarães Rocha, Sonia Maria Dozzi Brucki   +3 more
doaj   +1 more source

Lecanemab use in Chinese patients with Alzheimer's disease: a 12‐month multicenter real‐world study

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION We evaluated lecanemab's safety and cognitive outcomes in Chinese patients with Alzheimer's disease (AD) and the utility of blood‐based biomarkers (BBMs) for treatment guidance. METHODS A multicenter, real‐world cohort enrolled 1042 patients receiving lecanemab, with 453, 359, 97 patients followed up at 3, 6, 12 months ...
Hao Wu, Qin Chen, Min Fang, Huidong Tang, Huayan Liu, Jun Liu, Jiewen Zhang, Lijun Chi, Shuai Liu, Jiawei Xin, Lumin Leng, Pan Wang, Song Chi, Yi Li, Jianwen Chen, Ligong Zhang, Jinhong Zhang, Qiang Ma, Xuezhen Wang, Xinling Meng, Jianfei Nao, Xiangqing Li, Yan Lv, Yanhong Jia, Qing Zhao, Chunyan Liu, Jinghuan Gan, Jing Zhu, Yehua Song, Huaian Li, Min Fei, Xia Guo, Jingwen Liu, Guoping Peng, Xiaochun Chen, Yong Ji   +35 more
wiley   +1 more source