Results 31 to 40 of about 15,276 (177)

Connecting the dots: A narrative review of the relationship between heart failure and cognitive impairment

ESC Heart Failure, Volume 12, Issue 2, Page 1119-1131, April 2025.
Abstract Large clinical data underscore that heart failure is independently associated to an increased risk of negative cognitive outcome and dementia. Emerging evidence suggests that cerebral hypoperfusion, stemming from reduced cardiac output and vascular pathology, may contribute to the largely overlapping vascular dementia and Alzheimer's disease ...
Mauro Massussi, Maria Giulia Bellicini, Marianna Adamo, Andrea Pilotto, Marco Metra, Alessandro Padovani, Riccardo Proietti   +6 more
wiley   +1 more source

Amyloid-β-related angiitis presenting as leptomeningitis

BMJ Neurology Open
Background Inflammatory cerebral amyloid angiopathy (ICAA) is an atypical presentation of cerebral amyloid angiopathy (CAA), caused by an autoimmune reaction against cerebral beta-amyloid deposits.
Raquel González, Ana Ramirez, Pablo Gómez-Porro, Beatriz De La Puente, Lorena Fernández, Beatriz Brea, Joaquin Carneado   +6 more
doaj   +1 more source

Clustering of Cerebral Microbleeds in Cerebral Amyloid Angiopathy: A Flow Territory‐Based Analysis

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Cerebral microbleeds (CMBs) are a key imaging marker of cerebral amyloid angiopathy (CAA), but their individual spatial distribution and potential clustering remain poorly understood. Purpose This study assessed whether CMBs exhibit patient‐specific, flow territory‐based clustering in sporadic (sCAA) and Dutch‐type hereditary CAA (D‐
Manon R. Schipper, Reinier G. J. van der Zwet, Jelle J. Goeman, Thijs W. van Harten, Emma A. Koemans, Marieke J. H. Wermer, Marianne A. A. van Walderveen, Matthias J. P. van Osch   +7 more
wiley   +1 more source

The Association Between Positive Amyloid-PET and Cognitive Decline Is Not Always Supportive of Alzheimer’s Disease: Suggestions from a Case Report

Journal of Alzheimer's Disease Reports
Amyloid-β deposition is the pathological hallmark of both cerebral amyloid angiopathy and Alzheimer’s disease dementia, clinical conditions that can share cognitive decline and positive Amyloid-PET scan.
Gemma Lombardi, Valentina Berti, Andrea Ginestroni, Benedetta Nacmias, Sandro Sorbi   +4 more
doaj   +1 more source

Bone marrow mesenchymal stem cells protect against cerebral amyloid angiopathy by enhancing neutrophil mitocytosis

Neural Regeneration Research
Current treatments for cerebral amyloid angiopathy are mainly symptomatic and have limited efficacy, and there is a lack of targeted therapies. Mesenchymal stem cell transplantation improves cognitive and motor function in conditions such as Alzheimer’s ...
Mengyan Hu, Haotong Yi, Shisi Wang, Xinmei Kang, Yuxin Liu, Zhiruo Liu, Huipeng Huang, Qin Qin, Liling Yuan, Wei Cai, Wei Qiu, Zhengqi Lu, Sanxin Liu   +12 more
doaj   +1 more source

Cerebral Amyloid Angiopathy and Intracerebral Haemorrhage

Advances in Clinical Neuroscience & Rehabilitation, 2016
Cerebral amyloid angiopathy (CAA) is increasingly recognised, particularly as a cause of intracerebral haemorrhage and dementia. CAA may present to the clinical neurologist in a range of circumstances, including inpatient or outpatient general neurology (
David Werring, Gargi Banerjee
doaj   +1 more source

Circadian rhythms and chronotherapy in Alzheimer's disease: Mechanisms and therapeutic implications

Neuroprotection, EarlyView.
Circadian dysregulation contributes to Alzheimer's disease through sleep disruption, clock‐gene dysfunction, neuroinflammation, impaired proteostasis, and metabolic imbalance. These alterations promote cognitive decline and disease progression, while circadian biomarkers and chronotherapeutic interventions offer opportunities for precision diagnosis ...
Bivek Singh, Filippo Pigazzani, Roberto Manfredini   +2 more
wiley   +1 more source

Human brain matters: Navigating the neuropathology of COVID‐19

Brain Pathology, EarlyView.
Severe COVID‐19 is associated with vascular dysregulation and chronic neuroinflammation, leading to axonal injury and neurodegeneration. In long COVID or PASC, persistent alterations in neuroimaging and biofluid biomarkers reflect ongoing neuronal damage and neuroinflammation, contributing to long‐term neurological symptoms including fatigue, cognitive
Juliana M. Nieuwland, Angelica Scaramuzza, Marianna Bugiani, Wilma D. J. van de Berg, Jinte Middeldorp   +4 more
wiley   +1 more source

Dysregulated TIE‐2 expression is associated with blood‐brain barrier leakiness and Alzheimer's disease‐related neuropathology

Brain Pathology, EarlyView.
Ince et al., have analysed TIE‐1 and ‐2 expression in human brain tissue, including microvessel‐enriched fractions (MVF) and covering a spectrum of AD‐associated pathology, and in CSF from independent cohorts spanning a clinical spectrum from normal cognition to AD.
Selvi Ince, Carol Van Hulle, Gwendlyn Kollmorgen, Clara Quijano‐Rubio, Carey Gleason, Barbara B. Bendlin, Ozioma Okonkwo, Sanjay Asthana, Kaj Blennow, Henrik Zetterberg, Sterling C. Johnson, Seth Love, J. Scott Miners   +12 more
wiley   +1 more source

Cerebral Amyloid Angiopathy-Related Inflammation following Multiple Cancers and Chemotherapies

Case Reports in Neurology, 2022
Cerebral amyloid angiopathy-related inflammation (CAA-ri) is a rare autoimmune encephalopathy of aging caused by an autoantibody immune response against Aβ protein deposited in the brain of older adults affected by cerebral amyloid angiopathy (CAA) and ...
Christophe Severijns, Emilie Drion, Elettra Bianchi, Pierre Maquet   +3 more
doaj   +1 more source