Results 31 to 40 of about 577,451 (225)

Amyloid and tau in the brain in sporadic Alzheimer’s disease: defining the chicken and the egg [PDF]

, 2014
In the October 2013 issue of Acta Neuropathologica there were three very interesting articles on: Amyloid or tau: the chicken or the egg? In the first article, David Mann and John Hardy argued that the deposition of aggregated amyloid β (Aβ) protein in ...
Cheryl A. Hawkes, Roy O. Weller, Roxana O. Carare, Hawkes, Cheryl A., Carare, Roxana O., Weller, Roy O.   +5 more
core   +1 more source

Pathogenesis of cerebral amyloid angiopathy

Brain Research Reviews, 2003
Cerebral amyloid angiopathy (CAA) is the result of the deposition of an amyloidogenic protein in cortical and leptomeningeal vessels. The most common type of CAA is caused by amyloid beta-protein (Abeta), which is particularly associated with Alzheimer's disease (AD).
Rensink, A.A.M., Waal, R.M.W. de, Kremer, H.P.H., Verbeek, M.M.   +3 more
openaire   +3 more sources

Parenchymal and vascular Aβ-deposition and its effects on the degeneration of neurons and cognition in Alzheimer's disease [PDF]

, 2008
The deposition of the amyloid β-protein (Aβ) is one of the pathological hallmarks of Alzheimer's disease (AD). Aβ-deposits show the morphology of senile plaques and cerebral amyloid angiopathy (CAA). Senile plaques and vascular Aβ-deposits occur first in
Griffin, W. Sue T., Braak, Heiko, Thal, Dietmar Rudolf, Thal, Dietmar   +3 more
core   +1 more source

Recurrent Subarachnoid Bleeding and Superficial Siderosis in a Patient with Histopathologically Proven Cerebral Amyloid Angiopathy

Case Reports in Neurology, 2011
A 68-year-old man with a history of hypertension presented with recurrent subarachnoid bleeding. Brain MRI showed superficial siderosis, and diagnostic cerebral angiograms did not show any intracranial vascular malformation or arterial aneurism.
P. Profice, F. Pilato, G. Della Marca, C. Colosimo, S. Gaudino, V. Arena, A. Pavone, V. Di Lazzaro   +7 more
doaj   +1 more source

Cerebral Amyloid Angiopathy: Emerging Concepts [PDF]

Journal of Stroke, 2015
Cerebral amyloid angiopathy (CAA) involves cerebrovascular amyloid deposition and is classified into several types according to the amyloid protein involved.
Masahito Yamada
doaj   +1 more source

An autopsy case of amyloid β-related angiitis with cognitive impairment, multiple infarcts and subcortical hemorrhage

Human Pathology: Case Reports, 2018
A 76-year-old female presented with cognitive impairment and multiple brain infarcts and died of massive subcortical cerebral hemorrhage. A premortem clinical diagnosis was not possible.
Takahiro Watanabe, MD, PhD, Shinichiro Ukon, MD, Takako Kihara, MD, Yoshi-Hiro Ide, MD, PhD, Shohei Matsuo, MD, Yuka Hayashi, MD, Shuhei Kasama, MD, PhD, Hiroo Yoshikawa, MD, PhD, Yuki Okano, Chiaki Uchida, Masahiro Yamamoto, Hiroyuki Hao, MD, PhD, Akio Kimura, MD, PhD, Seiichi Hirota, MD, PhD, Yoshitane Tsukamoto, MD, PhD   +14 more
doaj   +1 more source

Bicine promotes rapid formation of β-sheet-rich amyloid-β fibrils.

PLoS ONE, 2020
Fibrillar aggregates of amyloid-β (Aβ) are the main component of plaques lining the cerebrovasculature in cerebral amyloid angiopathy. As the predominant Aβ isoform in vascular deposits, Aβ40 is a valuable target in cerebral amyloid angiopathy research ...
Hye Yun Kim, HeeYang Lee, Jong Kook Lee, Hyunjin Vincent Kim, Key-Sun Kim, YoungSoo Kim   +5 more
doaj   +1 more source

Probable cerebral amyloid angiopathy

Journal of the Belgian Society of Radiology, 2010
Background: A 55-year-old man presented with short-term memory loss, headache, diplopia and visual hallucinations. Higher mental functions were normal. The patient had a previous medical history of seizures, and was under longstanding anti-epileptic treatment. Recently he had been diagnosed with multiple myeloma.
Pilet, B., Ozsarlak, Ö, Venstermans, C., Parizel, P.M.   +3 more
openaire   +5 more sources

Cerebral amyloid angiopathy as a cause of subarachnoid hemorrhage

, 1990
Cerebral amyloid angiopathy is a pathologic condition characterized by the deposition of amyloid in the walls of small vessels in the cerebral cortex and meninges.
Nukui, H, Allsop, D, Onaya, T, Ikeda, S, Endo, T, Ohshima, T   +5 more
core   +5 more sources

Drug-Induced Amyloid-Related Imaging Abnormalities: A Neurovascular Perspective on Risk Assessment

Pharmaceuticals
Background: Anti-amyloid therapies (AAT) are reshaping the therapeutic landscape of Alzheimer’s disease (AD), yet their implementation remains constrained by the risk of amyloid-related imaging abnormalities (ARIA).
Marialuisa Zedde, Mattia Losa, Andrea Donniaquio, Ilaria Gandoglia, Massimo Del Sette, Luca Roccatagliata, Fabrizio Piazza, Matteo Pardini, Rosario Pascarella   +8 more
doaj   +1 more source