Results 11 to 20 of about 46,178 (264)

Cerebral amyloid angiopathy-related inflammation: current status and future implications

Chinese Medical Journal, 2021
. Cerebral amyloid angiopathy-related inflammation (CAA-RI) is a rare but increasingly recognized subtype of CAA. CAA-RI consists of two subtypes: inflammatory cerebral amyloid angiopathy and amyloid β (Aβ)-related angiitis.
Juan-Juan Wu, Ming Yao, Jun Ni, Xiu-Yuan Hao   +3 more
doaj   +2 more sources

Understanding the Pathophysiology of Cerebral Amyloid Angiopathy [PDF]

International Journal of Molecular Sciences, 2020
Cerebral amyloid angiopathy (CAA), one of the main types of cerebral small vessel disease, is a major cause of spontaneous intracerebral haemorrhage and an important contributor to cognitive decline in elderly patients. Despite the number of experimental in vitro studies and animal models, the pathophysiology of CAA is still largely unknown.
Laura Gatti, Francesca Tinelli, Emma Scelzo, Francesco Arioli, Giuseppe Di Fede, Laura Obici, Leonardo Pantoni, Giorgio Giaccone, Paola Caroppo, Eugenio Agostino Parati, Anna Bersano   +10 more
openaire   +3 more sources

The Boston criteria version 2.0 for cerebral amyloid angiopathy: a multicentre, retrospective, MRI-neuropathology diagnostic accuracy study.

Lancet Neurology, 2022
BACKGROUND Cerebral amyloid angiopathy (CAA) is an age-related small vessel disease, characterised pathologically by progressive deposition of amyloid β in the cerebrovascular wall.
A. Charidimou, G. Boulouis, M. Frosch, J. Baron, M. Pasi, J. Albucher, G. Banerjee, Carmen Barbato, F. Bonneville, S. Brandner, L. Calvière, F. Caparros, B. Casolla, C. Cordonnier, M. Delisle, V. Deramecourt, M. Dichgans, E. Gokcal, J. Herms, M. Hernández-Guillamon, H. Jäger, Z. Jaunmuktane, J. Linn, S. Martinez-Ramirez, E. Martínez-Sáez, C. Mawrin, J. Montaner, S. Moulin, J. Olivot, F. Piazza, L. Puy, N. Raposo, M. Rodrigues, S. Roeber, J. R. Romero, N. Samarasekera, J. Schneider, S. Schreiber, F. Schreiber, Corentin Schwall, Colin Smith, Levente Szalardy, P. Varlet, A. Viguier, J. Wardlaw, Andrew D. Warren, F. Wollenweber, M. Zedde, M. van Buchem, M. Gurol, A. Viswanathan, R. Al‐Shahi Salman, E. Smith, D. Werring, S. Greenberg   +54 more
semanticscholar   +1 more source

Progression of cerebral amyloid angiopathy: a pathophysiological framework.

Lancet Neurology, 2023
Cerebral amyloid angiopathy, which is defined by cerebrovascular deposition of amyloid β, is a common age-related small vessel pathology associated with intracerebral haemorrhage and cognitive impairment.
E. Koemans, J. Chhatwal, Susanne J. van Veluw, E. V. van Etten, M. V. van Osch, M. V. van Walderveen, H. Sohrabi, M. Kozberg, Z. Shirzadi, G. Terwindt, M. van Buchem, E. Smith, D. Werring, R. Martins, M. Wermer, S. Greenberg   +15 more
semanticscholar   +1 more source

Macrophage lineage cells-derived migrasomes activate complement-dependent blood-brain barrier damage in cerebral amyloid angiopathy mouse model

Nature Communications, 2023
Accumulation of amyloid beta protein (Aβ) in brain vessels damages blood brain barrier (BBB) integrity in cerebral amyloid angiopathy (CAA). Macrophage lineage cells scavenge Aβ and produce disease-modifying mediators. Herein, we report that Aβ40-induced
M. Hu, Tiemei Li, Xiaomeng Ma, Sanxin Liu, Chunyi Li, Zhenchao Huang, Yinyao Lin, Ruizhen Wu, Shisi Wang, Danli Lu, T. Lu, X. Men, Shishi Shen, Huipeng Huang, Yuxin Liu, K. Song, Banghao Jian, Yuxuan Jiang, W. Qiu, Quentin Liu, Zhengqi Lu, W. Cai   +21 more
semanticscholar   +1 more source

Exploring cerebral amyloid angiopathy: Insights into pathogenesis, diagnosis, and treatment.

Journal of Neurological Sciences, 2023
Cerebral Amyloid Angiopathy (CAA) is a neurological disorder characterized by the deposition of amyloid plaques in the walls of cerebral blood vessels.
Mariagiovanna Cozza, Lucia Amadori, Virginia Boccardi   +2 more
semanticscholar   +1 more source

Clinical considerations in early-onset cerebral amyloid angiopathy

Brain : a journal of neurology, 2023
Cerebral amyloid angiopathy (CAA) is an important cerebral small vessel disease associated with brain haemorrhage and cognitive change. The commonest form, sporadic amyloid-β CAA, usually affects people in mid- to later life.
G. Banerjee, J. Collinge, Nick C Fox, T. Lashley, S. Mead, J. Schott, D. Werring, N. Ryan   +7 more
semanticscholar   +1 more source

Cryo-EM structures of Aβ40 filaments from the leptomeninges of individuals with Alzheimer’s disease and cerebral amyloid angiopathy

bioRxiv, 2023
We used electron cryo-microscopy (cryo-EM) to determine the structures of Aβ40 filaments from the leptomeninges of individuals with Alzheimer’s disease and cerebral amyloid angiopathy.
Yang Yang, A. Murzin, Sew Y. Peak-Chew, Catarina Franco, Kathy L. Newell, B. Ghetti, Michel Goedert, S. Scheres   +7 more
semanticscholar   +1 more source

Decreased cerebrospinal fluid Aβ 38, 40, 42, and 43 levels in sporadic and hereditary cerebral amyloid angiopathy

Annals of Neurology, 2023
Vascular amyloid β (Aβ) accumulation is the hallmark of cerebral amyloid angiopathy (CAA). The composition of cerebrospinal fluid (CSF) of CAA patients may serve as a diagnostic biomarker of CAA.
Anna M. de Kort, H. B. Kuiperij, Tainá M Marques, Lieke Jäkel, Emma van den Berg, Iris Kersten, Hugo E P van Berckel-Smit, Marco Duering, E. Stoops, W. F. Abdo, I. Rasing, S. Voigt, E. Koemans, K. Kaushik, Andrew D. Warren, S. Greenberg, G. Brinkmalm, G. Terwindt, M. Wermer, Floris H. B. M. Schreuder, C. Klijn, M. Verbeek   +21 more
semanticscholar   +1 more source

Inflammatory Cerebral Amyloid Angiopathy: A Broad Clinical Spectrum

Journal of Clinical Neurology, 2023
Cerebral amyloid angiopathy (CAA) is a common central nervous system (CNS) vasculopathy, which in some cases is associated with subacute encephalopathy, seizures, headaches, or strokes due to vascular inflammation directed against vascular amyloid ...
A. de Souza, Kate Tasker
semanticscholar   +1 more source