Results 61 to 70 of about 15,276 (177)

Minocycline in Severe Cerebral Amyloid Angiopathy: A Single‐Center Cohort Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Evidence from animal studies suggests that minocycline may reduce lobar intracerebral hemorrhage (ICH) recurrence in cerebral amyloid angiopathy, possibly by inhibiting perivascular extracellular matrix degradation in cerebral small vessels ...
Francesco Bax, Andrew Warren, Avia Abramovitz Fouks, Hilde van den Brink, Susanne J. van Veluw, Mariel G. Kozberg, Steven M. Greenberg   +6 more
doaj   +1 more source

Blood-Brain Barrier Dysfunction in Small Vessel Disease Related Intracerebral Hemorrhage

Frontiers in Neurology, 2018
Background and Purpose: Hypertensive vasculopathy and cerebral amyloid angiopathy are the two most common forms of cerebral small vessel disease.
Whitney M. Freeze, Whitney M. Freeze, Heidi I. L. Jacobs, Heidi I. L. Jacobs, Floris H. B. M. Schreuder, Robert J. van Oostenbrugge, Walter H. Backes, Frans R. Verhey, Catharina J. M. Klijn   +8 more
doaj   +1 more source

Plasma p‐tau217 detects Alzheimer's disease co‐pathology in cerebral amyloid angiopathy: Comparison to CSF biomarkers in the ANGMAR cohort

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Cerebral amyloid angiopathy (CAA) frequently co‐occurs with Alzheimer's disease (AD), generating mixed vascular–neurodegenerative phenotypes. Plasma phosphorylated tau (p‐tau)217 is a robust biomarker of AD, but its performance in CAA remains unclear. METHODS We studied 231 participants, including 50 patients with CAA (Boston v2.0)
Aida Fernández‐Lebrero, Joan Jiménez‐Balado, Greta García‐Escobar, José Contador, Isabel Estraguès‐Gázquez, Laia Peraferrer‐Montesinos, Rosa María Manero‐Borràs, Laura Ludovica Gramegna, Marc Viles, Ana Rodríguez Campello, Paula Ortiz‐Romero, Marina de Diego, Marta del Campo, Javier Torres‐Torronteras, Esther Jiménez‐Moyano, Helena Blasco‐Forniés, Marc Suárez‐Calvet, Angel Ois, Albert Puig‐Pijoan, Irene Navalpotro‐Gómez   +19 more
wiley   +1 more source

APOE and genetic risk variants influence Alzheimer's disease onset in carriers of an extra copy of APP, with and without Down syndrome

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION An extra copy of the amyloid precursor protein (APP) gene causes autosomal dominant Alzheimer's disease (AD) and AD in Down syndrome (DS), but the factors underlying variability in age at onset (AAO) remain unclear. We investigated whether sporadic AD risk variants modify AAO. METHODS We analyzed clinical and genetic data from 100
Joan Groeneveld, Danna Perlaza, Clàudia Olivé, Lou Grangeon, Niccolo Tesi, Aude Nicolas, Chenyang Jiang, Itziar de Rojas, David Wallon, Stéphane Rousseau, Marta Rovira, Diego Real de Asúa, Fernando Moldenhauer, Ruihao Mu, Kévin Cassinari, Aline Zarea, Joaquim Aumatell Escabias, Jean‐Charles Lambert, Yolande A. L. Pijnenburg, Marc Hulsman, Everard G. B. Vijverberg, Johannes Levin, Mathias Jucker, Eric McDade, Juan Fortea, Henne Holstege, Flora H. Duits, Lisa Vermunt, Maulikkumar Patel, Matthew Johnson, Alan E. Renton, Alison M. Goate, Carlos Cruchaga, Cyril Pottier, Maria Victoria Fernandez, Olivia Belbin, Gael Nicolas, Oriol Dols‐Icardo, Sven J. van der Lee, Dominantly Inherited Alzheimer Network   +39 more
wiley   +1 more source

Advances of cerebral amyloid angiopathy and related cognitive impairment

Chinese Journal of Contemporary Neurology and Neurosurgery, 2019
Cerebral amyloid angiopathy (CAA) is a common cerebral small vessel disease(cSVD) in clinic. It is characterized by the deposition of amyloid β-protein (Aβ) in the cerebral vascular wall, including small and medium arteries of pia mater and cortex and ...
Zhen ZHEN, Yan⁃jun GUO
doaj   +1 more source

The past, the present, and the future of preclinical mouse models for Alzheimer's disease and related dementias

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract Over the past decade, the Model Organism Development and Evaluation for Late‐Onset Alzheimer's Disease (MODEL‐AD) consortium has transformed preclinical Alzheimer's disease (AD) research by addressing critical limitations in traditional mouse models that failed to translate to human disease.
Adrian L. Oblak, Michael Sasner, Gregory W. Carter, Gareth R. Howell, Stacey J. Sukoff Rizzo, Karina Leal, Paul R. Territo, Bruce T. Lamb   +7 more
wiley   +1 more source

Research progress of cerebral amyloid angiopathy associated with inflammation

Chinese Journal of Contemporary Neurology and Neurosurgery, 2020
Cerebral amyloid angiopathy associated with inflammation (CAA⁃I) is a rare subtype of cerebral amyloid angiopathy (CAA), and is increasingly recognized by neurologists. CAA⁃Iischaracterized by the pathological hallmarks of both CAA and vasculitis.
Wen⁃hao ZHANG, Ran LIU, Yi⁃ning HUANG   +2 more
doaj  

Cerebrospinal Fluid Amyloid‐β Biomarkers Predict Future Hemorrhage in Patients with Cerebral Amyloid Angiopathy

Annals of Neurology, Volume 100, Issue 2, Page 391-399, August 2026.
Objective Accurately predicting future hemorrhagic events in patients with cerebral amyloid angiopathy (CAA) remains a major clinical challenge. It is unknown whether cerebrospinal fluid (CSF) biomarkers of amyloid‐beta (Aβ) pathology are associated with increased hemorrhage risk in this population.
Philipp Arndt, Malte Pfister, Valentina Perosa, Hendrik Mattern, Melis Tas, Lara Holzheimer, Johanna Engel, Marc Dörner, Marwa Al‐Dubai, Cornelia Garz, Eya Khadhraoui, Sebastian J. Müller, Patrick Müller, Sven G. Meuth, Katja Neumann, Stefanie Schreiber   +15 more
wiley   +1 more source

Simultaneous Assessment of Intracranial Artery and Paravascular CSF Pulsation Using 3D Whole‐Brain Diffusion‐Prepared Cine bSSFP (DECAF) MRI

Magnetic Resonance in Medicine, Volume 96, Issue 2, Page 727-740, August 2026.
ABSTRACT Purpose To propose a noninvasive and quantitative MRI approach to simultaneously assessing intracranial artery pulsation and paravascular cerebrospinal fluid (CSF) pulsation in the human brain. Methods We developed a 3D whole‐brain Diffusion‐prepared Cine bSSFP (DECAF) MRI technique, with improved motion‐sensitized driven‐equilibrium providing
Chang Ni, Xiangjian Hou, SeyyedKazem HashemizadehKolowri, Seong‐Eun Kim, Qiuting Wen, Nicholas A. Frost, J. Scott McNally, Chun Yuan, Xiaodong Ma   +8 more
wiley   +1 more source

Intracerebral Haemorrhage in the Top End of the Northern Territory; Risk Factors, Outcomes and the Presence of Cerebral Amyloid Angiopathy in Indigenous Peoples

Australian Journal of Rural Health, Volume 34, Issue 4, August 2026.
ABSTRACT Objective The prevalence of intracranial haemorrhage (ICH) and cerebral amyloid angiopathy (CAA) in the Northern Territory (NT) is unknown. This study aims to improve knowledge of haemorrhagic stroke in the NT, to evaluate the relevance of CAA and examine its association with chronic kidney disease (CKD).
Marianna Diamandopoulos, Alvaro Cervera, Geoffrey A. Donnan   +2 more
wiley   +1 more source