Results 61 to 70 of about 46,178 (264)

Correlating familial Alzheimer’s disease gene mutations with clinical phenotype [PDF]

, 2010
Alzheimer’s disease (AD) causes devastating cognitive impairment and an intense research effort is currently devoted to developing improved treatments for it.
Rossor, M.N., Ryan, N.S.
core   +1 more source

Intracranial Hemorrhage Due to Secondary Hypertension from Intracranial Large Vessel Occlusion [PDF]

, 2020
Simultaneous hemorrhagic and ischemic strokes have been previously reported in the literature. Typically, these occur in patients secondary to dialysis, cerebral amyloid angiopathy, or thrombotic thrombocytopenic purpura.1,2,3 However, this is the unique
Khan, Asif A., Rawal, Amit, Saeed, Omar, Waldman, Alex   +3 more
core  

Exercise, cognition and Alzheimer’s disease: More is not necessarily better [PDF]

, 2005
Regional hypoperfusion, associated with a reduction in cerebral metabolism, is a hallmark of Alzheimer’s disease (AD) and contributes to cognitive decline. Cerebral perfusion and hence cognition can be enhanced by exercise.
Adlard, Alessi, Anton, Attwell, Baumbach, Bierman, Carmeliet, Chen, Chen, Churchill, Cohen, Colcombe, Cooke, Corder, Cott, Critchley, Cumming, Daley, De la Torre, Dick Swaab, Diesfeldt, Dubelaar, Eldridge, Endres, Erik Scherder, Farkas, Fedele, Fernández-Vizarra, Folstein, Fratiglioni, Friedman, Graham, Guigoz, Hamel, Harkany, Hayward, Hellström, Herrmann, Herrmann, Hoffman, Huang, Hönigfeld, Iadecola, Ide, Ide, Ide, Jagust, Johnson, Jørgensen, Katz, Keller, Kivipelto, Koike, Koistinaho, Kubes, Kurosawa, Launer, Laura Eggermont, Lawton, Lazowski, Lehtovirta, Liesi, Lijnen, Lindenmuth, MacRae, Martel, Matsuda, Matsuda, Maxwell, Melchor, Meltzer, Meyer, Miklossy, Monji, Morgan, Moro, Mulder, Muldowney, Nagahama, Nagai, Nakajima, Namazi, Naso, Palleschi, Palmer, Parihar, Paul Luiten, Petersen, Plutchik, Pober, Pott, Powell, Prager, Prunell, Raven, Reiman, Reitan, Rolland, Roth, Salehi, Scherder, Schini-Kerth, Selley, Skoog, Smith, Sobel, Spinler, Srikiatkhachorn, Suzuki, Swaab, Swaab, Swaab, Swain, Tappen, Tappen, Teri, Tinetti, Tong, Tong, Tsolaki, Tucker, Tucker, Ueda, Ushijima, Van de Winckel, Van Dyck, Van Gelder, Wang, Warkentin, Wechsler, Wechsler, Weller, Wenk, Whelton, White, Wilson, Wolf, Zarit   +137 more
core   +1 more source

The Uppsala APP Mutation Promotes Wild‐Type Amyloid‐β Aggregation and Deposition In Vivo

Advanced Science, EarlyView.
We investigated in vivo cross‐seeding of amyloid‐β (Aβ) isoforms in transgenic mice co‐expressing wild‐typeAβ and the Uppsala‐mutant Aβ variant (AβUpp), lacking six central residues. Weleveraged MALDI‐MS imaging and hyperspectral microscopy to follow spatio‐temporalAβ deposition.
Junyue Ge, María Pagnon de la Vega, Silvia Zampar, Enrica Cerilli, Srinivas Koutarapu, Ling Wu, Paul Fraser, Sertan Arkan, Vilmantas Giedraitis, Lars Lannfelt, Greta Hultqvist, Stina Syvänen, Martin Ingelsson, Jörg Hanrieder, Dag Sehlin   +14 more
wiley   +1 more source

Spontaneous and Drug-Induced Amyloid-Related Imaging Abnormalities: Overlaps, Divergences, and Clinical Implications Across a Continuum Between Alzheimer’s Disease and Cerebral Amyloid Angiopathy

Biomolecules
Background: Amyloid-related imaging abnormalities (ARIA) have gained significance in the context of anti-amyloid therapies (AATs), exhibiting clinical and radiological manifestations that overlap with Cerebral Amyloid Angiopathy-related inflammation (CAA-
Marialuisa Zedde, Mattia Losa, Elena Grisafi, Davide D. Lucia, Ilaria Gandoglia, Massimo Del Sette, Matteo Pardini, Luca Roccatagliata, Rosario Pascarella, Fabrizio Piazza   +9 more
doaj   +1 more source

Vascular dementia: Current concepts and nomenclature harmonization. [PDF]

, 2012
Several types of cerebrovascular lesions are associated with cognitive decline, but the role of each type in dementia manifestation has yet to be determined.
Grinberg, Lea Tenenholz
core  

Biomimetic Ru‐Mn Nanozyme with Cascade Catalytic Activity Attenuates Secondary Brain Injury in Intracerebral Hemorrhage

Advanced Science, EarlyView.
Ru–Mn composite nanozymes are engineered to mimic dual‐enzyme cascade catalysis, enabling efficient ROS clearance and neuroinflammation suppression. In collagenase‐ and autologous blood‐induced ICH mouse models, intranasal and intravenous administration reduced hematoma volume, preserved BBB integrity, and improved neurological recovery.
Zhongxin Duan, Peng Li, Yue Wang, Xin Qi, Wanyu Wang, Yongzhong Cheng, Huabin Zhang, Xin Hu, Xiang Gao   +8 more
wiley   +1 more source

Cerebrospinal Fluid Amyloid‐β Biomarkers Predict Future Hemorrhage in Patients with Cerebral Amyloid Angiopathy

Annals of Neurology, EarlyView.
Objective Accurately predicting future hemorrhagic events in patients with cerebral amyloid angiopathy (CAA) remains a major clinical challenge. It is unknown whether cerebrospinal fluid (CSF) biomarkers of amyloid‐beta (Aβ) pathology are associated with increased hemorrhage risk in this population.
Philipp Arndt, Malte Pfister, Valentina Perosa, Hendrik Mattern, Melis Tas, Lara Holzheimer, Johanna Engel, Marc Dörner, Marwa Al‐Dubai, Cornelia Garz, Eya Khadhraoui, Sebastian J. Müller, Patrick Müller, Sven G. Meuth, Katja Neumann, Stefanie Schreiber   +15 more
wiley   +1 more source

Neuropathological correlates of cortical superficial siderosis in cerebral amyloid angiopathy

Brain : a journal of neurology, 2020
Cortical superficial siderosis (cSS) is an established hemorrhagic neuroimaging marker of cerebral amyloid angiopathy (CAA) and emerging as a strong independent risk factor for future lobar intracerebral hemorrhage.
Susanne J. van Veluw, A. Charidimou, M. Frosch, S. Greenberg   +3 more
semanticscholar   +1 more source

Connecting the dots: A narrative review of the relationship between heart failure and cognitive impairment

ESC Heart Failure, Volume 12, Issue 2, Page 1119-1131, April 2025.
Abstract Large clinical data underscore that heart failure is independently associated to an increased risk of negative cognitive outcome and dementia. Emerging evidence suggests that cerebral hypoperfusion, stemming from reduced cardiac output and vascular pathology, may contribute to the largely overlapping vascular dementia and Alzheimer's disease ...
Mauro Massussi, Maria Giulia Bellicini, Marianna Adamo, Andrea Pilotto, Marco Metra, Alessandro Padovani, Riccardo Proietti   +6 more
wiley   +1 more source