Results 61 to 70 of about 577,451 (225)

Cerebral Amyloid Angiopathy-Related Inflammation following Multiple Cancers and Chemotherapies

Case Reports in Neurology, 2022
Cerebral amyloid angiopathy-related inflammation (CAA-ri) is a rare autoimmune encephalopathy of aging caused by an autoantibody immune response against Aβ protein deposited in the brain of older adults affected by cerebral amyloid angiopathy (CAA) and ...
Christophe Severijns, Emilie Drion, Elettra Bianchi, Pierre Maquet   +3 more
doaj   +1 more source

Distinctly altered TRPC3 and TRPC6 expression patterns in human Alzheimer's disease cortex and hippocampus

Brain Pathology, EarlyView.
Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen, Zhengjun Wang, Jiaxing Wang, Dehui Kong, Xusheng Wang, Lu Lu, Peter T. Nelson, Fu‐Ming Zhou, Francesca‐Fang Liao   +8 more
wiley   +1 more source

Non‐Alzheimer Aβ deposits in the human CNS: Implications with hypoxia and related conditions

Brain Pathology, EarlyView.
An Aβ deposit in a non‐Alzheimer's brain from an individual who experienced hypoxia/energy failure. Abstract We recently reported the deposition of Aβ in the frontal cortex of individuals who died of acute coronavirus disease 2019 (COVID‐19), or who did not have COVID‐19 but had respiratory distress, or infants with severe cardiac malformations.
Esma Karlovich, David S. Priemer, Charles Harker Rhodes, Daniel P. Perl, Kurenai Tanji, James E. Goldman   +5 more
wiley   +1 more source

Clinicopathological and molecular heterogeneity of amyloid‐β in unnatural deaths under 70 years: A forensic autopsy–based study

Brain Pathology, EarlyView.
This study investigates amyloid‐beta (Aβ) pathology in a forensic autopsy cohort of relatively young individuals (40–69 years). Using detailed immunohistochemical analyses of multiple Aβ species, we demonstrate marked regional and molecular heterogeneity, particularly within the striatum.
Shojiro Ichimata, Yukiko Hata, Koji Yoshida, Ryo Tanaka, Shigeo Murayama   +4 more
wiley   +1 more source

Peak Width of Skeletonized Mean Diffusivity as Neuroimaging Biomarker in Cerebral Amyloid Angiopathy.

, 2021
International audienceBackground and purpose: Whole-brain network connectivity has been shown to be a useful biomarker of cerebral amyloid angiopathy and related cognitive impairment. We evaluated an automated DTI-based method, peak width of skeletonized
Duering, M, Charidimou, A, Zanon Zotin, M, Fotiadis, P, Greenberg, S, Pasi, M, Viswanathan, A, Boulouis, G, Schwab, K, Raposo, N, Etherton, M, Gurol, M, Xiong, L, Schoemaker, D, Schirmer, M, M. Pasi, M.R. Etherton, M.E. Gurol, D. Schoemaker, A. Charidimou, K. Schwab, G. Boulouis, M.C. Zanon Zotin, A. Viswanathan, S.M. Greenberg, Viswanathan, A., L. Xiong, P. Fotiadis, M. Duering, N. Raposo, M.D. Schirmer   +30 more
core   +1 more source

Cerebral amyloid angiopathy revealed by severe renal failure: A case report

Radiology Case Reports
Sporadic cerebral amyloid angiopathy is a common condition in the elderly, characterised by the accumulation of amyloid Aβ peptide in the walls of small cerebral arteries, leading to intracranial haemorrhage and cognitive impairment.
El Ouazzani Mouad, Bouchoual Mohammed, Boughmi Amine, Bounabe Rabia, Bigi Soufiane, Anibar Sara, Jabrane Marouane, Wakrim Soukaina, Arrayhani Mohamed   +8 more
doaj   +1 more source

Chronic traumatic encephalopathy in a neuropathologically confirmed Creutzfeldt–Jakob disease cohort

Brain Pathology, EarlyView.
Systematic neuropathological screening of 212 patients with Creutzfeldt–Jakob disease (55% women) identified chronic traumatic encephalopathy in three cases (1.4%), all men with a history of contact sports. These findings represent the first neuropathologically confirmed chronic traumatic encephalopathy cases reported in Spain.
Lluc Bertran, Iban Aldecoa, Arlène Sindikubwabo, Núria Vidal, Rafael Blesa, Mercè Martínez‐Corral, Carlos Nos, Verónica Santiago, Andrea González, Álex Iranzo, Christopher J. Nowinski, Ann C. McKee, Raquel Sánchez Valle, Laura Molina‐Porcel   +13 more
wiley   +1 more source

Amyloid Precursor Protein Variant, E665D, Associated With Unique Clinical and Biomarker Phenotype

American Journal of Alzheimer's Disease and Other Dementias, 2021
We describe a clinical, imaging and biomarker phenotype associated with an amyloid precursor gene (APP) E665D variant in a 45-year-old man with progressive cognitive and behavioral dysfunction.
Justin R. Abbatemarco MD, Stephen E. Jones MD, PhD, Mykol Larvie MD, Lynn M. Bekris PhD, Maria E. Khrestian MS, Kamini Krishnan PhD, James B. Leverenz MD   +6 more
doaj   +1 more source

Identification of Copy Number Variants as a Suspected Cause of Cerebral Small Vessel Disease

Clinical Genetics, EarlyView.
Whole‐exome sequencing of 111 patients with suspected familial cerebral small vessel disease (CSVD) identified novel copy number variants in four patients across NOTCH3, LMNB1, and COL4A2, using bioinformatic and molecular techniques. These validated CNVs suggest structural variation is an underrecognized potential causal contributor to monogenic CSVD ...
Solomon K. Guyler, Neven Maksemous, Rodney A. Lea, Robert A. Smith, Heidi G. Sutherland, Lyn R. Griffiths   +5 more
wiley   +1 more source

Immune Reactions Associated With Cerebral Amyloid Angiopathy

, 1996
Background and Purpose Cerebral amyloid angiopathy (CAA) occasionally coexists with cerebral vasculitis. An immune system may influence deposition or degradation of the amyloid in cerebral blood vessels. The purpose of this study
Masayuki Shintaku, Leifur Thorsteinsson, Eiichi Otomo, Naomi Suematsu, Masahito Yamada, Masaaki Matsushita, Yoshinori Itoh, Ólafur Jensson, Junichiro Kawamura   +8 more
core   +1 more source