Results 81 to 90 of about 46,178 (264)

Tau and apolipoprotein E modulate cerebrovascular tight junction integrity independent of cerebral amyloid angiopathy in Alzheimer’s disease

Alzheimer's & Dementia, 2020
Cerebrovascular pathologies including cerebral amyloid angiopathy (CAA) and blood‐brain barrier (BBB) dysregulation are prominent features in the majority of Alzheimer's disease (AD) cases.
Chia-Chen Liu, Yu Yamazaki, M. Heckman, Yuka A. Martens, Lin Jia, Akari Yamazaki, N. Diehl, Jing Zhao, Na Zhao, M. DeTure, Mary D. Davis, Lindsey M. Felton, Wenhui Qiao, Yonghe Li, Hongmei Li, Yuan Fu, Na Wang, Melissa C. Wren, Tomonori Aikawa, Marie-Louise Holm, Hiroshi Oue, Cynthia Linares, M. Allen, M. Carrasquillo, M. Murray, R. Petersen, N. Ertekin-Taner, D. Dickson, T. Kanekiyo, G. Bu   +29 more
semanticscholar   +1 more source

Amyloid‐β aggregates induce vasculopathy via ferroptosis in brain endothelial cells

Brain Pathology, EarlyView.
Blood–brain barrier (BBB) disruption is evident in brains with amyloidopathy. In this study, we demonstrate that amyloid β (Aβ) drives abnormal lipid metabolism and lipid droplet formation in brain endothelial cells, leading to lipid peroxidation and ferroptosis.
Suhyeon Son, Suji Kim, Min‐Tae Jeon, Moonseok Choi, Kyu‐Sung Kim, Suji Lee, Seung‐Yeol Nah, Do‐Geun Kim   +7 more
wiley   +1 more source

Cerebral Amyloid Angiopathy-Related Inflammation following Multiple Cancers and Chemotherapies

Case Reports in Neurology, 2022
Cerebral amyloid angiopathy-related inflammation (CAA-ri) is a rare autoimmune encephalopathy of aging caused by an autoantibody immune response against Aβ protein deposited in the brain of older adults affected by cerebral amyloid angiopathy (CAA) and ...
Christophe Severijns, Emilie Drion, Elettra Bianchi, Pierre Maquet   +3 more
doaj   +1 more source

Interpretable classification of Alzheimer's disease pathologies with a convolutional neural network pipeline. [PDF]

, 2018
Neuropathologists assess vast brain areas to identify diverse and subtly-differentiated morphologies. Standard semi-quantitative scoring approaches, however, are coarse-grained and lack precise neuroanatomic localization.
Beckett, Laurel, Chuang, Kangway V, DeCarli, Charles, Dugger, Brittany N, Jin, Lee-Way, Keiser, Michael J, Tang, Ziqi   +6 more
core  

Volumetric analysis of carotid plaque components and cerebral microbleeds: a correlative study [PDF]

, 2017
PURPOSE: The purpose of this work was to explore the association between carotid plaque volume (total and the subcomponents) and cerebral microbleeds (CMBs).
Anzidei, Michele, DI MARTINO, Michele, Francone, Marco, Lucatelli, Pierleone, Montisci, Roberto, Porcu, Michele, Saba, Luca, Sanfilippo, Roberto, Suri, Jasjit S.   +8 more
core   +1 more source

Emerging concepts in sporadic cerebral amyloid angiopathy.

Brain : a journal of neurology, 2017
Sporadic cerebral amyloid angiopathy is a common, well-defined small vessel disease and a largely untreatable cause of intracerebral haemorrhage and contributor to age-related cognitive decline.
A. Charidimou, G. Boulouis, M. Gurol, C. Ayata, B. Bacskai, M. Frosch, A. Viswanathan, S. Greenberg   +7 more
semanticscholar   +1 more source

A1 reactive astrocytes and a loss of TREM2 are associated with an early stage of pathology in a mouse model of cerebral amyloid angiopathy

Journal of Neuroinflammation, 2020
Background Cerebral amyloid angiopathy (CAA) is typified by the cerebrovascular deposition of amyloid. The mechanisms underlying the contribution of CAA to neurodegeneration are not currently understood.
Xavier Taylor, Pablo Cisternas, Y. You, Yin-jun You, S. Xiang, Yamil Marambio, Jie Zhang, R. Vidal, Cristian A. Lasagna-Reeves   +8 more
semanticscholar   +1 more source

Distinct regional patterns of synaptic vulnerability across hippocampal and parahippocampal subregions in Alzheimer's disease

Brain Pathology, EarlyView.
Synaptic loss in Alzheimer's disease predominantly affects the entorhinal cortex and parahippocampal gyrus. Amyloid‐β and p‐tau pathology show global associations with synaptic density but are limited in specific subregions. Instead, axonal damage associates with synaptic loss locally and in interconnected subregions.
Maud M. A. Bouwman, Irene Frigerio, Yvon Galis‐de Graaf, Wilma D. J. van de Berg, Laura E. Jonkman   +4 more
wiley   +1 more source

Convective infux/glymphatic system: tracers injected into the CSF enter and leave the brain along separate periarterial basement membrane pathways [PDF]

, 2018
Tracers injected into CSF pass into the brain alongside arteries and out again. This has been recently termed the "glymphatic system" that proposes tracers enter the brain along periarterial "spaces" and leave the brain along the walls of veins.
Albargothy, Nazira J., Carare, Roxana O., Hawkes, Cheryl A., Johnston, David A., MacGregor-Sharp, Matthew, Verma, Ajay, Weller, Roy O.   +6 more
core   +1 more source

Diagnosis of Cerebral Amyloid Angiopathy: Evolution of the Boston Criteria

Stroke, 2018
The history of how to diagnosis cerebral amyloid angiopathy (CAA) tells the story of the disease itself. CAA is defined by histopathology—deposition of β-amyloid in the cerebrovasculature—and through the 1980s the disorder was only diagnosed in patients ...
S. Greenberg, A. Charidimou
semanticscholar   +1 more source