Results 121 to 130 of about 251,874 (305)

Nasal Delivery of Engineered Exosomes via a Thermo‐Sensitive Hydrogel Depot Reprograms Glial Cells for Spinal Cord Repair

open access: yesAdvanced Science, EarlyView.
Engineered macrophage‐derived exosomes overexpressing GNA12 and GNA13 reprogram glial cells to promote neuroprotection and neural regeneration following SCI. A chitosan‐based thermosensitive hydrogel enables sustained intranasal exosome delivery, bypassing systemic barriers and enhancing therapeutic efficacy.
Yangyang Wang   +13 more
wiley   +1 more source

Translation of a Human‐Based Malaria‐on‐a‐Chip Phenotypic Disease Model for In Vivo Applications

open access: yesAdvanced Science, EarlyView.
Inoculation of the Malaria‐on‐a‐Chip model with human erythrocytes infected with Plasmodium falciparum can support the entire intraerythrocytic lifecycle for 7 days in vitro. Utilizing this human‐based, serum‐free model provides an alternative to animal testing by introducing a human‐based, preclinical alternative for antimalarial therapeutic delivery.
Michael J. Rupar   +15 more
wiley   +1 more source

Flexible Dual‐Modal Sensors Based on Single‐Crystalline Silicon Membranes for Continuous Monitoring of Photoplethysmography and Skin Temperature

open access: yesAdvanced Science, EarlyView.
A flexible light‐temperature dual‐modal sensor is demonstrated with silicon‐based diode, of which the operation mode, i.e., photodetection and temperature sensing, can be conveniently controlled by the biased condition. Engineering demonstrations illustrate the applicability of the sensor to continuously monitor photoplethysmography and skin ...
Yanle He   +7 more
wiley   +1 more source

Advanced Brain‐on‐a‐Chip for Wetware Computing: A Review

open access: yesAdvanced Science, EarlyView.
Exploring Low‐Power, Beyond‐Silicon‐Computing Bio‐Computing: Brain‐on‐a‐Chip Technology. This article reviews the applications of Brain‐on‐a‐Chip in Wetware Computing, including in vitro‐cultured brain organoids, microelectrode arrays, electrophysiological interfaces, and microfluidic platforms, as well as data processing methods. It also looks forward
Shangchen Li   +11 more
wiley   +1 more source

Artificial Intelligence‐Driven Proteomics Identifies Plasma Protein Signatures for Diagnosis and Stratification of Behçet's Disease

open access: yesAdvanced Science, EarlyView.
Molecular and functional landscape of BD progression and severity based on in‐depth proteomics. Tree boosting machine learning models with favorable performance in BD diagnosis and stratification. Efficient biomarker panels for BD diagnosis and stratification. .
Linlin Cheng   +6 more
wiley   +1 more source

The Effect of Ventilation and Acetazolamide (Diamox) on Cerebral Blood Flow in Chronic Respiratory Acidosis

open access: bronze, 1968
Jung Ho Lee   +3 more
openalex   +1 more source

NIR‐II AIEgens for High‐Contrast Intravital Fluorescence Angiography: Recent Advances and Prospects

open access: yesAggregate, EarlyView.
This review delineates recent advances in NIR‐II AIEgens for high‐contrast intravital fluorescence angiography applications, which are systematically categorized by the anatomical location of vessels, encompassing brain, abdomen, hindlimb, ear, axilla, kidney, and tumor.
Zhijun Zhang   +8 more
wiley   +1 more source

Design, Control, and Clinical Applications of Magnetic Actuation Systems: Challenges and Opportunities

open access: yesAdvanced Intelligent Systems, Volume 7, Issue 3, March 2025.
This review aims to provide a broad understanding for interdisciplinary researchers in engineering and clinical applications. It addresses the development and control of magnetic actuation systems (MASs) in clinical surgeries and their revolutionary effects in multiple clinical applications.
Yingxin Huo   +3 more
wiley   +1 more source

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