Results 21 to 30 of about 347,069 (262)

New-onset constipation at acute stage after stroke: incidence, risk factors, and impact on stroke rehabilitation

Frontiers in Neurology
BackgroundThe rapid increase in the global aging population poses a major public health challenge due to the prevalence of stroke. Constipation represents a significant complication of stroke, significantly impacting quality of life.
Zhaoyang Lv, Shiyu Fan, Xv Ma, Feng Liu, Hao Wu, Zhihong Shi, Meng Wang, Tao Yu, Pan Wang, Shuai Liu, Yong Ji   +10 more
doaj   +1 more source

Nomogram for the prediction of surgical site infection following spinal surgery: a multicenter retrospective study

Frontiers in Medicine
ObjectiveSurgical site infection (SSI) represents a prevalent postoperative complication associated with spinal surgery, contributing to increased morbidity and mortality rates.
Yang Sun, Yang Sun, Yang Sun, Qi Li, Qi Li, Qi Li, Pengfei Zhai, Pengfei Zhai, Pengfei Zhai, Rui Zhang, Hongguang Wang, Hongguang Wang, Hongguang Wang, Xiaoguang Tong, Xiaoguang Tong, Xiaoguang Tong   +15 more
doaj   +1 more source

Analysis of the efficacy and safety of spinal cord stimulation in the treatment of high-risk diabetic foot

Chinese Journal of Contemporary Neurology and Neurosurgery
Objective To evaluate the efficacy and safety of spinal cord stimulation (SCS) in the treatment of high-risk diabetic foot. Methods From January 2023 to May 2024, 25 patients with high-risk diabetic foot who underwent SCS were admitted to Tianjin Huanhu ...
CHEN Xiao-chen, ZHU Bao-chang, LIU Bao-long, LIU Xin, LI Zhi-tao   +4 more
doaj   +1 more source

Aerobic exercise training increases cerebral blood flow in postmenopausal women

Artery Research, 2012
Background: Age-related decrease in cerebral blood flow is a risk factor for cognitive decline. Aerobic exercise training improves vascular and cognitive functions.
Nobuhiko Akazawa, Youngju Choi, Asako Miyaki, Jun Sugawara, Ryuichi Ajisaka, Seiji Maeda   +5 more
doaj   +1 more source

Hypothalamic-pituitary dysfunction in severe traumatic brain injury long-term outcomes

Chinese Journal of Contemporary Neurology and Neurosurgery
The incidence of hypothalamic-pituitary dysfunction in patients with severe traumatic brain injury (sTBI) reaches up to 40%. However, it is often masked by clinical manifestations similar to those of sTBI, leading to underdiagnosis and misdiagnosis ...
QIU Bing-hui, DU Jia-shu, ZHONG Qing-lei, ZHUO Jie, HE Shan   +4 more
doaj   +1 more source

Consensus Standards and Recommendations for Developmental and Cognitive Surveillance, Screening, and Evaluation in Sickle Cell Disease: Executive Summary From the National Alliance of Sickle Cell Centers Neurocognitive Workgroup

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Neurodevelopmental and neurocognitive difficulties are prevalent among individuals with sickle cell disease and warrant prompt identification and support. This Special Report provides an executive summary of standards and recommendations for surveillance, screening, and evaluation for development and cognition across the lifespan developed by ...
Alyssa M. Schlenz, Donna Murdaugh, Andrew M. Heitzer, Jennifer N. Longoria, Wendy Santos‐Modesitt, Arianna Martin, Judy Cavazos, Jeff Schatz, Catherine R. Hoyt, Alison King, Eboni I. Lance, Steven Hardy, Marsha Treadwell   +12 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Glutamate load fosters spreading depolarization under osmotic stress in brain slices

Frontiers in Cellular Neuroscience
IntroductionCerebral edema is a hallmark of lesion progression after acute ischemic stroke (AIS) and a major contributor to the evolution of spreading depolarizations (SDs). SDs trigger extracellular glutamate accumulation and excitotoxic injury, yet the
Rita Frank, Rita Frank, Stephane Marinesco, Ferenc Bari, Ákos Menyhárt, Ákos Menyhárt, Eszter Farkas, Eszter Farkas   +7 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source