Results 1 to 10 of about 4,624 (210)

Next-Generation Sequencing Advances the Genetic Diagnosis of Cerebral Cavernous Malformation (CCM) [PDF]

Antioxidants, 2022
Cerebral Cavernous Malformation (CCM) is a cerebrovascular disease of genetic origin that predisposes to seizures, focal neurological deficits and fatal intracerebral hemorrhage. It may occur sporadically or in familial forms, segregating as an autosomal
Valerio Benedetti, Rosalia Canzoneri, Andrea Perrelli, Carlo Arduino, Andrea Zonta, Alfredo Brusco, Saverio Francesco Retta   +6 more
doaj   +5 more sources

The Role of Immune Infiltration and Oxidative Stress in the Progression of Cerebral Cavernous Malformation [PDF]

Brain and Behavior
Purpose of Review To review how the immune microenvironment and oxidative stress modulate the initiation, maturation, and hemorrhagic conversion of cerebral cavernous malformations (CCM) and to appraise the therapeutic potential of immune‐directed ...
Xuesai Zhu, Yizhi Yao, Tengbo Yu, Xiao Xiao   +3 more
doaj   +4 more sources

Cerebral Cavernous Malformation (CCM)-like Vessel Lesion in the Aged ANKS1A-deficient Brain. [PDF]

Exp Neurobiol, 2023
In this study, we show that ANKS1A is specifically expressed in the brain endothelial cells of adult mice. ANKS1A deficiency in adult mice does not affect the differentiation, growth, or patterning of the cerebrovascular system; however, its absence ...
Lee J, Lee H, Shin M, Park S.
europepmc   +4 more sources

Focal epilepsy caused by single cerebral cavernous malformation (CCM) is associated with regional and global resting state functional connectivity (FC) disruption [PDF]

NeuroImage: Clinical, 2019
Epilepsy, including the type with focal onset, is increasingly viewed as a disorder of the brain network. Here we employed the functional connectivity (FC) metrics estimated from the resting state functional MRI (rsfMRI) to investigate the changes of ...
Jason D'Cruz, Matthew Hefner, Christina Ledbetter, Clifton Frilot, Brady Howard, Peimin Zhu, Rosario Riel-Romero, Christina Notarianni, Eduardo Gonzalez Toledo, Anil Nanda, Hai Sun   +10 more
doaj   +3 more sources

Use of balloon angioplasty for patients with intracranial large atherosclerotic acute ischemic stroke and cerebral cavernous malformation: a case report [PDF]

Frontiers in Neurology
Thus far, clinical data relating to the treatment of cerebral cavernous malformation (CCM) patients with acute stroke (AIS) are incredibly scare due to the low incidence of CCM.
Yiwan Wang, Tianyu Wang, Jiangmin Liang
doaj   +3 more sources

Single-cell transcriptome profiling reveals dynamic cell populations and immune infiltration in cerebral cavernous malformation [PDF]

Frontiers in Immunology
IntroductionThe cellular subpopulations and signaling pathways in the pathological tissues of cerebral cavernous malformation (CCM) remain incompletely understood. To gain a deeper understanding of the pathogenesis of CCM, we aimed to comprehensively map
Zhiguang Han, Chengxu Lei, Zhenyu Zhou, Yutong Liu, Yuanli Zhao, Shihao He   +5 more
doaj   +3 more sources

Cerebral cavernous malformation with prolonged postoperative paralysis due to perilesional inflammation: illustrative case. [PDF]

J Neurosurg Case Lessons
BACKGROUND: Postoperative symptom exacerbation after resection of cerebral cavernous malformations (CCMs) is usually due to surgical damage to the eloquent areas or venous outflow obstruction from injury to a developmental venous anomaly (DVA ...
Inai S, Sano N, Takeuchi Y, Makino Y, Yamamoto Hattori E, Takada S, Tanji M, Mineharu Y, Arakawa Y.   +8 more
europepmc   +4 more sources

The frameshift Leu220Phefs*2 variant in KRIT1 accounts for early acute bleeding in patients affected by cerebral cavernous malformation [PDF]

Interdisciplinary Neurosurgery, 2021
Background and Objectives: Cerebral cavernous malformation (CCM) is a neurovascular disease characterized by abnormally expanded and tortuous microvessels with increased predisposition to thrombosis and focal hemorrhage.
Autilia Tommasina Buonagura, Teresa Somma, Francesca Vitulli, Giuseppina Vitiello, Immacolata Andolfo, Felice Esposito, Roberta Russo, Achille Iolascon, Paolo Cappabianca   +8 more
doaj   +3 more sources

Familial Multiple Cavernous Malformation Syndrome: MR Features in This Uncommon but Silent Threat [PDF]

Journal of the Belgian Society of Radiology, 2016
Cerebral cavernous malformations (CCM) are vascular malformations in the brain and spinal cord. The familial form of cerebral cavernous malformation (FCCM) is uncommon.
Marc Mespreuve, Filip Vanhoenacker, Marc Lemmerling   +2 more
doaj   +5 more sources

Inflammatory Mechanisms in a Neurovascular Disease: Cerebral Cavernous Malformation

Brain Sciences, 2023
Cerebral cavernous malformation (CCM) is a common cerebrovascular malformation causing intracranial hemorrhage, seizures, and focal neurologic deficits.
Ying Li, Abhinav Srinath, Roberto J. Alcazar-Felix, Stephanie Hage, Akash Bindal, Rhonda Lightle, Robert Shenkar, Changbin Shi, Romuald Girard, Issam A. Awad   +9 more
doaj   +2 more sources