Results 161 to 170 of about 1,916 (204)

Common and distinct circulating microRNAs in four neurovascular disorders. [PDF]

open access: yesBiochem Biophys Rep
Koskimäki J   +19 more
europepmc   +1 more source

Towards precision nanomedicine for cerebrovascular diseases with emphasis on Cerebral Cavernous Malformation (CCM)

open access: yesExpert Opinion on Drug Delivery, 2021
Introduction: Cerebrovascular diseases encompass various disorders of the brain vasculature, such as ischemic/hemorrhagic strokes, aneurysms, and vascular malformations, also affecting the central nervous system leading to a large variety of transient or permanent neurological disorders. They represent major causes of mortality and long-term disability
Andrea Perrelli   +2 more
exaly   +5 more sources

Endothelial Cell–Pericyte Interactions in the Pathogenesis of Cerebral Cavernous Malformations (CCMs)

Cold Spring Harbor Perspectives in Medicine, 2022
Cerebral cavernous malformations (CCMs), consisting of multiple, dilated capillary channels formed by a single layer of endothelium and lacking parenchymal cells, are exclusively to the brain. Patients with inherited autosomal-dominant CCMs carry loss-of-function mutations in one of three genes: CCM1, CCM2, and CCM3. It is not known why CCM lesions are
Wang, Min, Jenny Huanjiao, Zhou
openaire   +2 more sources

YKL-40 can promote angiogenesis in sporadic cerebral cavernous malformation (CCM)

Journal of Clinical Neuroscience, 2019
The factors affecting the formation of sporadic CCMs remain unclear. A cDNA microarray was used to identify characteristic gene expression patterns in sporadic CCMs. Transcription level of YKL-40 was confirmed by reverse transcription-polymerase chain reaction (RT-PCR).
Yaying Song, Peiliang Li
exaly   +3 more sources

Cerebral Cavernous Malformations (CCM)

2020
This volume provides experimental approaches aimed to characterize the Cerebral Cavernous Malformations (CCM) disease and to define the cellular and molecular mechanisms underlying this pathology. Chapters are divided into four sections providing a general overview of the natural history, epidemiology, and pathogenetic mechanisms of CCM disease ...
Lorenza Trabalzini   +2 more
openaire   +1 more source

Untreated cerebral cavernous malformation (CCM) – impact on quality of life

2019
Objective: To estimate health related quality of life (QOL) with the diagnosis of an untreated cerebral cavernous malformation (CCM) and to analyze possible influencing factors. Methods: We performed a cross-sectional study based on our prospective uni-center CCM database (2017-2018), using standardized[for full text, please go to the a.m. URL]
Herten, A   +6 more
openaire   +1 more source

Blood prognostic biomarker signatures for hemorrhagic cerebral cavernous malformations (CCMs)

2023
Abstract Background Cerebral cavernous malformations (CCMs) is a neurological disorder that causes enlarged intracranial capillaries in the brain, leading to an increased risk of hemorrhagic strokes, which is a leading cause of death and disability worldwide.
Jacob Croft   +6 more
openaire   +1 more source

Patterns of expression of the three cerebral cavernous malformation (CCM) genes during embryonic and postnatal brain development

Gene Expression Patterns, 2006
Cerebral Cavernous Malformation (CCM) is a disease characterized by capillary-venous lesions mostly located in the central nervous system. It occurs both as a sporadic and hereditary autosomal dominant condition. Three CCM genes have been identified and shown to encode the KRIT1 (CCM1), MGC4607 (CCM2) and PDCD10 (CCM3) proteins whose functions are so ...
Elisabeth Tournier-Lasserve
exaly   +3 more sources

Relevance of CCM gene polymorphisms for clinical management of sporadic cerebral cavernous malformations

Journal of the Neurological Sciences, 2017
Cerebral cavernous malformations (CCMs) are clusters of capillaries in the brain that may cause focal deficits or seizures in affected patients. They occur in both sporadic and inherited autosomal dominant form. Germline mutations in CCM1, CCM2 and CCM3 were identified in familial cases. Over the past 13years we performed sequencing and MLPA of the CCM
Rinaldi, Carmela   +6 more
openaire   +3 more sources

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