Results 171 to 180 of about 1,916 (204)
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2020
Glyoxalase 1 (Glo1) is a glutathione (GSH)-dependent enzyme that catalyzes the isomerization of the hemithioacetal formed non-enzymatically from methylglyoxal (MG) and GSH to S-D-lactoylglutathione (SLG). The activity of Glo1 is measured spectrophotometrically by following the increase of absorbance at 240 nm and 25 °C, attributable to the formation of
Antognelli C., Talesa V. N., Retta S. F.
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Glyoxalase 1 (Glo1) is a glutathione (GSH)-dependent enzyme that catalyzes the isomerization of the hemithioacetal formed non-enzymatically from methylglyoxal (MG) and GSH to S-D-lactoylglutathione (SLG). The activity of Glo1 is measured spectrophotometrically by following the increase of absorbance at 240 nm and 25 °C, attributable to the formation of
Antognelli C., Talesa V. N., Retta S. F.
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2021
Objective: To estimate quality of life (QoL) during the natural course of patients with untreated cerebral cavernous malformations (CCM) using a one-year longitudinal follow up. Methods: 246 consecutive cases of CCM were included in a prospective longitudinal study assessing QoL and neurological/psychiatric[for full text, please go to the a.m. URL]
Herten, A +9 more
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Objective: To estimate quality of life (QoL) during the natural course of patients with untreated cerebral cavernous malformations (CCM) using a one-year longitudinal follow up. Methods: 246 consecutive cases of CCM were included in a prospective longitudinal study assessing QoL and neurological/psychiatric[for full text, please go to the a.m. URL]
Herten, A +9 more
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2020
The application of next generation sequencing (NGS) technique has a great impact on complex disease studies. Indeed, genetic heterogeneity, phenotypic variability, and disease rarity are all factors that make the traditional diagnostic approach to genetic disorders, whereby a specific gene is selected for sequencing based on the clinical phenotype ...
Benedetti V. +4 more
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The application of next generation sequencing (NGS) technique has a great impact on complex disease studies. Indeed, genetic heterogeneity, phenotypic variability, and disease rarity are all factors that make the traditional diagnostic approach to genetic disorders, whereby a specific gene is selected for sequencing based on the clinical phenotype ...
Benedetti V. +4 more
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Cerebral cavernous malformations (CCM) – the second symptomatic haemorrhage – long-term follow-up
2019Objective: Risk for recurrent symptomatic hemorrhage in CCM is an important factor in decision making/consultation of patients. In this report, we analyze the risk and time pattern of re-hemorrhage events after a first initial bleeding. Methods: We performed a cross-sectional study based on[for full text, please go to the a.m. URL]
Rauscher, S +6 more
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Study of the DNA promoter methylation of CCM genes in human cerebral cavernous malformation
2019Objective: CCM is the second most common cerebrovascular disease and is classified as familial (20%) and sporadic (80%) forms. Loss of function mutation of three CCM genes can cause the familial CCM. However, the mechanism causing sporadic CCM remains unclear. Considering the DNA promoter [for full text, please go to the a.m. URL]
Saban, DV +5 more
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2020
Cerebral cavernous malformation (CCM) is a rare cerebrovascular disorder of genetic origin consisting of closely clustered, abnormally dilated and leaky capillaries (CCM lesions), which occur predominantly in the central nervous system. CCM lesions can be single or multiple and may result in severe clinical symptoms, including focal neurological ...
Retta S. F. +3 more
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Cerebral cavernous malformation (CCM) is a rare cerebrovascular disorder of genetic origin consisting of closely clustered, abnormally dilated and leaky capillaries (CCM lesions), which occur predominantly in the central nervous system. CCM lesions can be single or multiple and may result in severe clinical symptoms, including focal neurological ...
Retta S. F. +3 more
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Brain Tumor Pathology, 2013
Developments in magnetic resonance imaging (MRI) techniques have dramatically increased the detection of cerebral cavernous malformations (CCMs). Conservative treatment is often recommended for asymptomatic cases. However, CCMs occasionally harbor malignant gliomas.
Junkoh, Yamamoto +3 more
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Developments in magnetic resonance imaging (MRI) techniques have dramatically increased the detection of cerebral cavernous malformations (CCMs). Conservative treatment is often recommended for asymptomatic cases. However, CCMs occasionally harbor malignant gliomas.
Junkoh, Yamamoto +3 more
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Journal of neurosurgical sciences, 2015
Cerebral cavernous malformation (CCM) is a vascular disease of proven genetic origin, which may arise sporadically or can be inherited as autosomal dominant condition with incomplete penetrance and highly variable expressivity. CCM lesions manifest across a range of different phenotypes, including wide interindividual differences in lesion number, size
TRAPANI, ELIANA +1 more
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Cerebral cavernous malformation (CCM) is a vascular disease of proven genetic origin, which may arise sporadically or can be inherited as autosomal dominant condition with incomplete penetrance and highly variable expressivity. CCM lesions manifest across a range of different phenotypes, including wide interindividual differences in lesion number, size
TRAPANI, ELIANA +1 more
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2019
70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für ...
Dammann, P +6 more
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70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für ...
Dammann, P +6 more
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Free Radical Biology and Medicine, 2016
Cerebral Cavernous Malformation (CCM) is a major cerebrovascular disease of genetic origin affecting 0.3-0.5% of the population and characterized by abnormally enlarged and leaky capillaries that predispose to seizures, neurological deficits and intracerebral hemorrhage.
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Cerebral Cavernous Malformation (CCM) is a major cerebrovascular disease of genetic origin affecting 0.3-0.5% of the population and characterized by abnormally enlarged and leaky capillaries that predispose to seizures, neurological deficits and intracerebral hemorrhage.
openaire +2 more sources