Results 171 to 180 of about 4,624 (210)
Expert Opinion on Drug Delivery, 2021 Introduction: Cerebrovascular diseases encompass various disorders of the brain vasculature, such as ischemic/hemorrhagic strokes, aneurysms, and vascular malformations, also affecting the central nervous system leading to a large variety of transient or
A. Perrelli +8 more
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Methods in molecular biology, 2020
Glyoxalase 1 (Glo1) is a glutathione (GSH)-dependent enzyme that catalyzes the isomerization of the hemithioacetal formed non-enzymatically from methylglyoxal (MG) and GSH to S-D-lactoylglutathione (SLG). The activity of Glo1 is measured spectrophotometrically by following the increase of absorbance at 240 nm and 25 °C, attributable to the formation of
C. Antognelli, V. Talesa, S. Retta
semanticscholar +5 more sources
Glyoxalase 1 (Glo1) is a glutathione (GSH)-dependent enzyme that catalyzes the isomerization of the hemithioacetal formed non-enzymatically from methylglyoxal (MG) and GSH to S-D-lactoylglutathione (SLG). The activity of Glo1 is measured spectrophotometrically by following the increase of absorbance at 240 nm and 25 °C, attributable to the formation of
C. Antognelli, V. Talesa, S. Retta
semanticscholar +5 more sources
YKL-40 can promote angiogenesis in sporadic cerebral cavernous malformation (CCM)
Journal of Clinical Neuroscience, 2019The factors affecting the formation of sporadic CCMs remain unclear. A cDNA microarray was used to identify characteristic gene expression patterns in sporadic CCMs. Transcription level of YKL-40 was confirmed by reverse transcription-polymerase chain reaction (RT-PCR).
Yuan Shi +3 more
semanticscholar +3 more sources
Methods in molecular biology, 2020
The application of next generation sequencing (NGS) technique has a great impact on complex disease studies. Indeed, genetic heterogeneity, phenotypic variability, and disease rarity are all factors that make the traditional diagnostic approach to genetic disorders, whereby a specific gene is selected for sequencing based on the clinical phenotype ...
Valerio Benedetti +4 more
semanticscholar +3 more sources
The application of next generation sequencing (NGS) technique has a great impact on complex disease studies. Indeed, genetic heterogeneity, phenotypic variability, and disease rarity are all factors that make the traditional diagnostic approach to genetic disorders, whereby a specific gene is selected for sequencing based on the clinical phenotype ...
Valerio Benedetti +4 more
semanticscholar +3 more sources
Highlights in Science Engineering and Technology, 2023
The weakened blood vessels associated with cerebral cavernous malformation (CCM) can result in symptoms such as seizures, stroke-like symptoms, headaches, sensory disturbances, and life-threatening hemorrhages.
Zhe Song
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The weakened blood vessels associated with cerebral cavernous malformation (CCM) can result in symptoms such as seizures, stroke-like symptoms, headaches, sensory disturbances, and life-threatening hemorrhages.
Zhe Song
semanticscholar +1 more source
Gene Expression Patterns, 2006
Cerebral Cavernous Malformation (CCM) is a disease characterized by capillary-venous lesions mostly located in the central nervous system. It occurs both as a sporadic and hereditary autosomal dominant condition. Three CCM genes have been identified and shown to encode the KRIT1 (CCM1), MGC4607 (CCM2) and PDCD10 (CCM3) proteins whose functions are so ...
N. Petit +3 more
semanticscholar +3 more sources
Cerebral Cavernous Malformation (CCM) is a disease characterized by capillary-venous lesions mostly located in the central nervous system. It occurs both as a sporadic and hereditary autosomal dominant condition. Three CCM genes have been identified and shown to encode the KRIT1 (CCM1), MGC4607 (CCM2) and PDCD10 (CCM3) proteins whose functions are so ...
N. Petit +3 more
semanticscholar +3 more sources
Cold Spring Harbor Perspectives in Medicine, 2022
Cerebral cavernous malformations (CCMs), consisting of multiple, dilated capillary channels formed by a single layer of endothelium and lacking parenchymal cells, are exclusively to the brain. Patients with inherited autosomal-dominant CCMs carry loss-of-function mutations in one of three genes: CCM1, CCM2, and CCM3. It is not known why CCM lesions are
Wang, Min, Jenny Huanjiao, Zhou
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Cerebral cavernous malformations (CCMs), consisting of multiple, dilated capillary channels formed by a single layer of endothelium and lacking parenchymal cells, are exclusively to the brain. Patients with inherited autosomal-dominant CCMs carry loss-of-function mutations in one of three genes: CCM1, CCM2, and CCM3. It is not known why CCM lesions are
Wang, Min, Jenny Huanjiao, Zhou
openaire +2 more sources
Cerebral Cavernous Malformations (CCM)
2020This volume provides experimental approaches aimed to characterize the Cerebral Cavernous Malformations (CCM) disease and to define the cellular and molecular mechanisms underlying this pathology. Chapters are divided into four sections providing a general overview of the natural history, epidemiology, and pathogenetic mechanisms of CCM disease ...
Lorenza Trabalzini +2 more
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Blood prognostic biomarker signatures for hemorrhagic cerebral cavernous malformations (CCMs)
2023AbstractBackgroundCerebral cavernous malformations (CCMs) is a neurological disorder that causes enlarged intracranial capillaries in the brain, leading to an increased risk of hemorrhagic strokes, which is a leading cause of death and disability worldwide.ObjectivesThe current treatment options for CCMs are limited, highlighting the need for ...
Jacob Croft +6 more
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Journal of the Neurological Sciences, 2017
Cerebral cavernous malformations (CCMs) are clusters of capillaries in the brain that may cause focal deficits or seizures in affected patients. They occur in both sporadic and inherited autosomal dominant form. Germline mutations in CCM1, CCM2 and CCM3 were identified in familial cases. Over the past 13years we performed sequencing and MLPA of the CCM
Rinaldi, Carmela +6 more
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Cerebral cavernous malformations (CCMs) are clusters of capillaries in the brain that may cause focal deficits or seizures in affected patients. They occur in both sporadic and inherited autosomal dominant form. Germline mutations in CCM1, CCM2 and CCM3 were identified in familial cases. Over the past 13years we performed sequencing and MLPA of the CCM
Rinaldi, Carmela +6 more
openaire +3 more sources