Results 21 to 30 of about 4,624 (210)

Pharmacological blocking of neutrophil extracellular traps attenuates immunothrombosis and neuroinflammation in cerebral cavernous malformation [PDF]

Nature Cardiovascular Research
Cerebral cavernous malformation (CCM) is a neurovascular disease with symptoms such as strokes, hemorrhages and neurological deficits. With surgery being the only treatment strategy, understanding the molecular mechanisms of CCM is crucial in finding ...
Daniel, Geoffrey, Fernando, Dinesh
core   +2 more sources

Inflammation in Cerebral Cavernous Malformations: Differences Between Malformation Related Epilepsy vs. Symptomatic Hemorrhage [PDF]

Cells
Background and Objective: Cerebral cavernous malformation (CCM) is a vascular disorder causing seizures, neurological deficits, and hemorrhagic stroke. It can be sporadic or inherited via CCM1, CCM2, or CCM3 gene mutations.
Jan Rodemerk, Adrian Engel, Julius L. H. Horstmann, Laurèl Rauschenbach, Marvin Darkwah Oppong, Alejandro N. Santos, Andreas Junker, Cornelius Deuschl, Michael Forsting, Yuan Zhu, Ramazan Jabbarli, Karsten H. Wrede, Börge Schmidt, Ulrich Sure, Philipp Dammann   +14 more
doaj   +2 more sources

Molecular Genetic Features of Cerebral Cavernous Malformations (CCM) Patients: An Overall View from Genes to Endothelial Cells [PDF]

Cells, 2021
Cerebral cavernous malformations (CCMs) are vascular lesions that affect predominantly microvasculature in the brain and spinal cord. CCM can occur either in sporadic or familial form, characterized by autosomal dominant inheritance and development of ...
Giulia Riolo, Claudia Ricci, Stefania Battistini   +2 more
doaj   +4 more sources

Outcomes after surgical and nonsurgical treatment of pediatric cerebral cavernous malformation

Pediatric Investigation, Volume 8, Issue 2, Page 126-134, June 2024.
Pediatric cerebral cavernous malformation (CCM) is a rarely encountered vascular entity. Comparative study on surgical excision and nonsurgical management outcomes of CCM in pediatrics is limited.
Haohao Zhang, Qishuai Yu, Zhiqi Mao, Liang Zhang, Xinguang Yu   +4 more
semanticscholar   +2 more sources

Transcriptomic signatures of individual cell types in cerebral cavernous malformation

Cell Communication and Signaling
Cerebral cavernous malformation (CCM) is a hemorrhagic neurovascular disease with no currently available therapeutics. Prior evidence suggests that different cell types may play a role in CCM pathogenesis.
Ying Li, Romuald Girard, Abhinav Srinath, Diana Vera Cruz, Cezary Ciszewski, Chang Chen, Rhonda Lightle, Sharbel Romanos, Je Yeong Sone, Thomas Moore, Dorothy DeBiasse, Agnieszka Stadnik, Justine J. Lee, Robert Shenkar, Janne Koskimäki, Miguel A. Lopez-Ramirez, Douglas A. Marchuk, Mark H. Ginsberg, Mark L. Kahn, Changbin Shi, Issam A. Awad   +20 more
doaj   +2 more sources

Large language models assisted multi-effect variants mining on cerebral cavernous malformation familial whole genome sequencing

Computational and Structural Biotechnology Journal
Cerebral cavernous malformation (CCM) is a polygenic disease with intricate genetic interactions contributing to quantitative pathogenesis across multiple factors.
Yiqi Wang, Jinmei Zuo, Chao Duan, Hao Peng, Jia Huang, Liang Zhao, Li Zhang, Zhiqiang Dong   +7 more
doaj   +2 more sources

Case report: A second case of cerebral cavernous malformation after high-dose chemotherapy for medulloblastoma

Frontiers in Oncology
The development of cerebral cavernous malformations (CCMs) is a well-recognized sequela of irradiation to the brain in pediatric tumors, particularly in medulloblastoma, glioma, and acute lymphoblastic leukaemia.
Maria Grazia Pionelli, Federica Mazio, Maria Elena Errico, Carmela Russo, Adriana Cristofano, Eugenio Maria Covelli, Vittoria Donofrio, Maria Capasso, Michele Antonio Capozza, Fabiola De Gregorio, Serena Ruotolo, Massimo Eraldo Abate, Giuseppe Cinalli   +12 more
doaj   +2 more sources

Familial Cerebral Cavernous Malformations: Pathophysiology, Genetics, Biomarkers, and Treatment Perspectives. [PDF]

J Neurochem
Cerebral cavernous malformations (CCMs) are vascular lesions in the brain caused by inherited genetic mutations in the CCM1/2/3 genes that disrupt normal blood vessel function. This work demonstrates that these mutations lead to endothelial dysfunction, inflammation, and iron accumulation, which can be detected by magnetic resonance imaging (MRI) and ...
Fontes-Dantas FL, da Fontoura Galvão G, Cunha AM, de Sena Murteira Pinheiro P, Morandi V, de Souza JM.   +5 more
europepmc   +2 more sources

A Chinese Family With Cerebral Cavernous Malformation Caused by a Frameshift Mutation of the CCM1 Gene: A Case Report and Review of the Literature

Frontiers in Neurology, 2022
BackgroundFamilial cerebral cavernous malformation (FCCM) is a vascular malformation disease closely linked to three identified genes: KRIT1/CCM1, MGC4607/CCM2 and PDCD10/CCM3.
Wenyu Liu, Wenyu Liu, Ming Liu, Ming Liu, Di Lu, Di Lu, Jiwei Wang, Jiwei Wang, Zexin Cao, Zexin Cao, Xuchen Liu, Xuchen Liu, Zichao Feng, Zichao Feng, Bin Huang, Bin Huang, Xinyu Wang, Xinyu Wang   +17 more
doaj   +1 more source

Cerebral Cavernous Malformations and Focal Drug-Resistant Epilepsy: Behind a Quid Pro Quo of Lesion and Epileptogenic Networks. [PDF]

Eur J Neurol
ABSTRACT Background Cerebral cavernous malformations (CCMs) contribute to focal drug‐resistant epilepsy (fDRE), with surgical outcomes varying due to an incomplete understanding of the interplay between CCM‐impacted regions and areas exhibiting ictal or interictal epileptogenicity.
Bratu IF, de Clerck L, Catenoix H, Valton L, Aupy J, Nica A, Rheims S, Aubert-Conil S, Benoit J, Makhalova J, Galli O, Villalon SM, Bartolomei F.   +12 more
europepmc   +2 more sources